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Dataset Description
  • Dataset Name: 18477577
  • Species: Human
  • Method: Addiction array gene list
  • No. of Genes: 130
  • Publication: Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
  • Dataset Summary: To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

    Gene list of this dataset (130 genes)
    GeneIDSymbolNameGenetic location
    113ADCY7adenylate cyclase 716q12-q13
    124ADH1Aalcohol dehydrogenase 1A (class I), alpha polypeptide4q21-q23
    125ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide4q21-q23
    126ADH1Calcohol dehydrogenase 1C (class I), gamma polypeptide4q21-q23
    127ADH4alcohol dehydrogenase 4 (class II), pi polypeptide4q21-q24|4q22
    128ADH5alcohol dehydrogenase 5 (class III), chi polypeptide4q21-q25
    130ADH6alcohol dehydrogenase 6 (class V)4q23
    131ADH7alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide4q23-q24
    148ADRA1Aadrenergic, alpha-1A-, receptor8p21-p11.2
    150ADRA2Aadrenergic, alpha-2A-, receptor10q24-q26
    151ADRA2Badrenergic, alpha-2B-, receptor2p13-q13
    152ADRA2Cadrenergic, alpha-2C-, receptor4p16
    154ADRB2adrenergic, beta-2-, receptor, surface5q31-q32
    216ALDH1A1aldehyde dehydrogenase 1 family, member A19q21.13
    217ALDH2aldehyde dehydrogenase 2 family (mitochondrial)12q24.2
    409ARRB2arrestin, beta 217p13
    552AVPR1Aarginine vasopressin receptor 1A12q14-q15
    553AVPR1Barginine vasopressin receptor 1B1q32
    627BDNFbrain-derived neurotrophic factor11p13
    9607CARTPTCART prepropeptide5q13.2
    847CATcatalase11p13
    885CCKcholecystokinin3p22-p21.3
    886CCKARcholecystokinin A receptor4p15.1-p15.2
    887CCKBRcholecystokinin B receptor11p15.4
    8851CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)17q11.2
    1128CHRM1cholinergic receptor, muscarinic 111q13
    1129CHRM2cholinergic receptor, muscarinic 27q31-q35
    1131CHRM3cholinergic receptor, muscarinic 31q43
    1132CHRM4cholinergic receptor, muscarinic 411p12-p11.2
    1133CHRM5cholinergic receptor, muscarinic 515q26
    1137CHRNA4cholinergic receptor, nicotinic, alpha 420q13.2-q13.3
    1141CHRNB2cholinergic receptor, nicotinic, beta 2 (neuronal)1q21.3
    9575CLOCKclock homolog (mouse)4q12
    1268CNR1cannabinoid receptor 1 (brain)6q14-q15
    1312COMTcatechol-O-methyltransferase22q11.21-q11.23|22q11.21
    1385CREB1cAMP responsive element binding protein 12q34
    1392CRHcorticotropin releasing hormone8q13
    1393CRHBPcorticotropin releasing hormone binding protein5q11.2-q13.3
    1394CRHR1corticotropin releasing hormone receptor 117q12-q22
    1395CRHR2corticotropin releasing hormone receptor 27p15.1
    1454CSNK1Ecasein kinase 1, epsilon22q13.1
    1571CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 110q24.3-qter
    1621DBHdopamine beta-hydroxylase (dopamine beta-monooxygenase)9q34
    1622DBIdiazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)2q12-q21
    1644DDCdopa decarboxylase (aromatic L-amino acid decarboxylase)7p11
    1812DRD1dopamine receptor D15q35.1
    1813DRD2dopamine receptor D211q23
    1814DRD3dopamine receptor D33q13.3
    1815DRD4dopamine receptor D411p15.5
    1816DRD5dopamine receptor D54p16.1
    2166FAAHfatty acid amide hydrolase1p35-p34
    54738FEVFEV (ETS oncogene family)2q36
    2353FOSv-fos FBJ murine osteosarcoma viral oncogene homolog14q24.3
    8061FOSL1FOS-like antigen 111q13
    2355FOSL2FOS-like antigen 22p23.3
    2555GABRA2gamma-aminobutyric acid (GABA) A receptor, alpha 24p12
    2556GABRA3gamma-aminobutyric acid (GABA) A receptor, alpha 3Xq28
    2557GABRA4gamma-aminobutyric acid (GABA) A receptor, alpha 44p12
    2559GABRA6gamma-aminobutyric acid (GABA) A receptor, alpha 65q34
    2560GABRB1gamma-aminobutyric acid (GABA) A receptor, beta 14p12
    2561GABRB2gamma-aminobutyric acid (GABA) A receptor, beta 25q34
    2562GABRB3gamma-aminobutyric acid (GABA) A receptor, beta 315q11.2-q12
    2563GABRDgamma-aminobutyric acid (GABA) A receptor, delta1p|1p36.3
    2564GABREgamma-aminobutyric acid (GABA) A receptor, epsilonXq28
    2566GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 25q31.1-q33.1
    2567GABRG3gamma-aminobutyric acid (GABA) A receptor, gamma 315q12
    55879GABRQgamma-aminobutyric acid (GABA) receptor, thetaXq28
    2571GAD1glutamate decarboxylase 1 (brain, 67kDa)2q31
    2572GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)10p11.23
    51083GALgalanin prepropeptide11q13.2
    2741GLRA1glycine receptor, alpha 15q32
    2742GLRA2glycine receptor, alpha 2Xp22.1-p21.3
    2743GLRBglycine receptor, beta4q31.3
    10243GPHNgephyrin14q23.3
    2897GRIK1glutamate receptor, ionotropic, kainate 121q22.11
    2902GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 19q34.3
    2903GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A16p13.2
    2904GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B12p12
    2905GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C17q25
    2911GRM1glutamate receptor, metabotropic 16q24
    2932GSK3Bglycogen synthase kinase 3 beta3q13.3
    3060HCRThypocretin (orexin) neuropeptide precursor17q21
    3350HTR1A5-hydroxytryptamine (serotonin) receptor 1A5q11.2-q13
    3351HTR1B5-hydroxytryptamine (serotonin) receptor 1B6q13
    3356HTR2A5-hydroxytryptamine (serotonin) receptor 2A13q14-q21
    3357HTR2B5-hydroxytryptamine (serotonin) receptor 2B2q36.3-q37.1
    3358HTR2C5-hydroxytryptamine (serotonin) receptor 2CXq24
    3359HTR3A5-hydroxytryptamine (serotonin) receptor 3A11q23.1
    9177HTR3B5-hydroxytryptamine (serotonin) receptor 3B11q23.1
    3725JUNjun oncogene1p32-p31
    3952LEPleptin7q31.3
    4128MAOAmonoamine oxidase AXp11.3
    4129MAOBmonoamine oxidase BXp11.23
    5594MAPK1mitogen-activated protein kinase 122q11.2|22q11.21
    1432MAPK14mitogen-activated protein kinase 146p21.3-p21.2
    5595MAPK3mitogen-activated protein kinase 316p11.2
    8777MPDZmultiple PDZ domain protein9p24-p22
    4803NGFnerve growth factor (beta polypeptide)1p13.1
    4852NPYneuropeptide Y7p15.1
    4886NPY1Rneuropeptide Y receptor Y14q31.3-q32
    4887NPY2Rneuropeptide Y receptor Y24q31
    4889NPY5Rneuropeptide Y receptor Y54q31-q32
    2908NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)5q31.3
    4915NTRK2neurotrophic tyrosine kinase, receptor, type 29q22.1
    4923NTSR1neurotensin receptor 1 (high affinity)20q13
    23620NTSR2neurotensin receptor 22p25.1
    4985OPRD1opioid receptor, delta 11p36.1-p34.3
    4986OPRK1opioid receptor, kappa 18q11.2
    4987OPRL1opiate receptor-like 120q13.33
    4988OPRM1opioid receptor, mu 16q24-q25
    5020OXToxytocin, prepro- (neurophysin I)20p13
    5173PDYNprodynorphin20pter-p12
    5179PENKproenkephalin8q23-q24
    5368PNOCprepronociceptin8p21
    5443POMCproopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)2p23.3
    84152PPP1R1Bprotein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)17q12
    5581PRKCEprotein kinase C, epsilon2p21
    6571SLC18A2solute carrier family 18 (vesicular monoamine), member 210q25
    2030SLC29A1solute carrier family 29 (nucleoside transporters), member 16p21.2-p21.1
    140679SLC32A1solute carrier family 32 (GABA vesicular transporter), member 120q11.23
    6538SLC6A11solute carrier family 6 (neurotransmitter transporter, GABA), member 113p25.3
    6540SLC6A13solute carrier family 6 (neurotransmitter transporter, GABA), member 1312p13.3
    6530SLC6A2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 216q12.2
    6531SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 35p15.3
    6532SLC6A4solute carrier family 6 (neurotransmitter transporter, serotonin), member 417q11.1-q12
    6534SLC6A7solute carrier family 6 (neurotransmitter transporter, L-proline), member 75q31-q32
    6863TAC1tachykinin, precursor 17q21-q22
    7054THtyrosine hydroxylase11p15.5
    7166TPH1tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)11p15.3-p14
    121278TPH2tryptophan hydroxylase 212q21.1