Logo
Home Search BLAST Integration Document Link Support Citation

Dataset Description
  • Dataset Name: 18477577
  • Species: Human
  • Method: Addiction array gene list
  • No. of Genes: 130
  • Publication: Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
  • Dataset Summary: To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

    Gene list of this dataset (130 genes)
    Page: 1 2 3 list all   
    GeneIDSymbolNameGenetic location
    2166FAAHfatty acid amide hydrolase1p35-p34
    54738FEVFEV (ETS oncogene family)2q36
    2353FOSv-fos FBJ murine osteosarcoma viral oncogene homolog14q24.3
    8061FOSL1FOS-like antigen 111q13
    2355FOSL2FOS-like antigen 22p23.3
    2555GABRA2gamma-aminobutyric acid (GABA) A receptor, alpha 24p12
    2556GABRA3gamma-aminobutyric acid (GABA) A receptor, alpha 3Xq28
    2557GABRA4gamma-aminobutyric acid (GABA) A receptor, alpha 44p12
    2559GABRA6gamma-aminobutyric acid (GABA) A receptor, alpha 65q34
    2560GABRB1gamma-aminobutyric acid (GABA) A receptor, beta 14p12
    2561GABRB2gamma-aminobutyric acid (GABA) A receptor, beta 25q34
    2562GABRB3gamma-aminobutyric acid (GABA) A receptor, beta 315q11.2-q12
    2563GABRDgamma-aminobutyric acid (GABA) A receptor, delta1p|1p36.3
    2564GABREgamma-aminobutyric acid (GABA) A receptor, epsilonXq28
    2566GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 25q31.1-q33.1
    2567GABRG3gamma-aminobutyric acid (GABA) A receptor, gamma 315q12
    55879GABRQgamma-aminobutyric acid (GABA) receptor, thetaXq28
    2571GAD1glutamate decarboxylase 1 (brain, 67kDa)2q31
    2572GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)10p11.23
    51083GALgalanin prepropeptide11q13.2
    2741GLRA1glycine receptor, alpha 15q32
    2742GLRA2glycine receptor, alpha 2Xp22.1-p21.3
    2743GLRBglycine receptor, beta4q31.3
    10243GPHNgephyrin14q23.3
    2897GRIK1glutamate receptor, ionotropic, kainate 121q22.11
    2902GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 19q34.3
    2903GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A16p13.2
    2904GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B12p12
    2905GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C17q25
    2911GRM1glutamate receptor, metabotropic 16q24
    2932GSK3Bglycogen synthase kinase 3 beta3q13.3
    3060HCRThypocretin (orexin) neuropeptide precursor17q21
    3350HTR1A5-hydroxytryptamine (serotonin) receptor 1A5q11.2-q13
    3351HTR1B5-hydroxytryptamine (serotonin) receptor 1B6q13
    3356HTR2A5-hydroxytryptamine (serotonin) receptor 2A13q14-q21
    3357HTR2B5-hydroxytryptamine (serotonin) receptor 2B2q36.3-q37.1
    3358HTR2C5-hydroxytryptamine (serotonin) receptor 2CXq24
    3359HTR3A5-hydroxytryptamine (serotonin) receptor 3A11q23.1
    9177HTR3B5-hydroxytryptamine (serotonin) receptor 3B11q23.1
    3725JUNjun oncogene1p32-p31
    3952LEPleptin7q31.3
    4128MAOAmonoamine oxidase AXp11.3
    4129MAOBmonoamine oxidase BXp11.23
    5594MAPK1mitogen-activated protein kinase 122q11.2|22q11.21
    1432MAPK14mitogen-activated protein kinase 146p21.3-p21.2
    5595MAPK3mitogen-activated protein kinase 316p11.2
    8777MPDZmultiple PDZ domain protein9p24-p22
    4803NGFnerve growth factor (beta polypeptide)1p13.1
    4852NPYneuropeptide Y7p15.1
    4886NPY1Rneuropeptide Y receptor Y14q31.3-q32
    Page: 1 2 3 list all