Gene Page: NAALAD2

Summary ?
GeneID10003
SymbolNAALAD2
SynonymsGCPIII|GPCIII|NAADALASE2|NAALADASE2
DescriptionN-acetylated alpha-linked acidic dipeptidase 2
ReferenceMIM:611636|HGNC:HGNC:14526|Ensembl:ENSG00000077616|HPRD:07494|Vega:OTTHUMG00000166368
Gene typeprotein-coding
Map location11q14.3
Pascal p-value0.042
Sherlock p-value0.929
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6876210chr5178961709NAALAD2100030.1trans
rs4810210chr2059454298NAALAD2100030.16trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C1QB0.720.70
C1QA0.700.68
C1QC0.690.64
RNASE60.670.59
SLC2A50.660.61
TYROBP0.630.63
HCLS10.630.59
ADORA30.620.56
FCER1G0.610.59
GPSM30.600.52
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
UPF3B-0.39-0.46
THOC2-0.39-0.42
MURC-0.37-0.34
ZNF326-0.37-0.40
HNRNPA2B1-0.37-0.38
ZNF300-0.37-0.31
KIAA1949-0.37-0.30
FNBP1L-0.37-0.30
RTF1-0.37-0.40
ZNF669-0.37-0.33

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008236serine-type peptidase activityNASglutamate (GO term level: 6)10085079 
GO:0004180carboxypeptidase activityNAS10085079 
GO:0016805dipeptidase activityNAS10085079 
GO:0008270zinc ion bindingIEA-
GO:0008239dipeptidyl-peptidase activityNAS10085079 
GO:0008237metallopeptidase activityIEA-
GO:0008233peptidase activityIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0042135neurotransmitter catabolic processIEAneuron, axon, Synap, Neurotransmitter (GO term level: 9)-
GO:0006508proteolysisNAS10085079 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneNAS10085079 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BERENJENO TRANSFORMED BY RHOA DN 394258All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217143All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290172All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS 179105All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185114All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6 469239All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH DN 3125All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448282All SZGR 2.0 genes in this pathway
WANG MLL TARGETS 289188All SZGR 2.0 genes in this pathway