Gene Page: PIGK

Summary
GeneID  10026
Symbol  PIGK
Synonyms  GPI8|MGC22559
Description  phosphatidylinositol glycan anchor biosynthesis, class K
See related  HGNC:8965|MIM:605087|Ensembl:ENSG00000142892|HPRD:05474|
Locus tag  RP4-564M11.1
Gene type  protein-coding
Map location  1p31.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.02692 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KIAA01740.860.86
HEATR60.860.86
STT3A0.850.86
C9orf640.850.85
PRPSAP10.850.86
CAPN70.840.85
TSR10.840.84
C17orf710.840.85
PPP1R80.840.86
RSPRY10.840.85
Top 10 negatively co-expressed genes
MT-CO2-0.71-0.79
AF347015.31-0.70-0.78
MT-CYB-0.67-0.76
AF347015.27-0.67-0.76
AF347015.8-0.67-0.77
AF347015.21-0.67-0.80
AF347015.33-0.66-0.74
IFI27-0.65-0.72
AF347015.2-0.63-0.76
C5orf53-0.63-0.66
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003923GPI-anchor transamidase activityIMP10793132 
GO:0005515protein bindingIPI10793132 |11483512 
GO:0004197cysteine-type endopeptidase activityIEA-
GO:0008233peptidase activityIEA-
GO:0034235GPI anchor bindingTAS10793132 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006467protein thiol-disulfide exchangeTAS12582175 
GO:0006508proteolysisIEA-
GO:0016255attachment of GPI anchor to proteinEXP1846368 
GO:0016255attachment of GPI anchor to proteinTAS11483512 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0042765GPI-anchor transamidase complexIMP10793132 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ALPPALP | FLJ61142 | PALP | PLAPalkaline phosphatase, placental (Regan isozyme)-HPRD,BioGRID11278620 |12616539 
CANXCNX | FLJ26570 | IP90 | P90calnexinAffinity Capture-MSBioGRID12582175 
GPAA1GAA1 | hGAA1glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)-HPRD,BioGRID10793132 |12052837 
PIGTCGI-06 | FLJ41596 | MGC8909 | NDAPphosphatidylinositol glycan anchor biosynthesis, class T-HPRD12052837 
-HPRD,BioGRID12582175 
ULBP2N2DL2 | RAET1HUL16 binding protein 2Affinity Capture-MSBioGRID12582175 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS 2517All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PROTEINS 518242All SZGR genes in this pathway
REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS 2619All SZGR genes in this pathway
REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION 188116All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
WILLIAMS_ESR2_TARGETS_UP 2818All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
QI_PLASMACYTOMA_DN 10063All SZGR genes in this pathway
ELLWOOD_MYC_TARGETS_UP 138All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SURVIVAL_DN 11376All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-410270127071Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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