Gene Page: ARPC5

Summary
GeneID  10092
Symbol  ARPC5
Synonyms  ARC16|MGC88523|dJ127C7.3|p16-Arc
Description  actin related protein 2/3 complex, subunit 5, 16kDa
See related  HGNC:708|MIM:604227|Ensembl:ENSG00000162704|HPRD:11969|
Locus tag  RP1-127C7.3
Gene type  protein-coding
Map location  1q25.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SUFU0.970.95
C14orf1180.960.95
RNF380.960.96
RFX70.960.96
ZNF3980.950.96
ZNF3170.950.97
DCAF50.950.97
DCP1A0.950.95
RRP1B0.950.95
PRRC10.950.95
Top 10 negatively co-expressed genes
C5orf53-0.71-0.77
AF347015.31-0.71-0.88
MT-CO2-0.70-0.89
AIFM3-0.70-0.77
FXYD1-0.70-0.88
S100B-0.69-0.83
AF347015.33-0.69-0.85
AF347015.27-0.69-0.86
HLA-F-0.69-0.75
IFI27-0.68-0.84
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingIEA-
GO:0005515protein bindingIPI17353931 
GO:0005200structural constituent of cytoskeletonTAS9230079 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006928cell motionTAS9230079 
GO:0030036actin cytoskeleton organizationTAS9359840 
GO:0030833regulation of actin filament polymerizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0005856cytoskeletonIEA-
GO:0005737cytoplasmTAS9359840 
GO:0005885Arp2/3 protein complexTAS9230079 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTR2ARP2ARP2 actin-related protein 2 homolog (yeast)Arp2/3 complex subunits p16 and Arp2 interactBIND11741539 
ACTR3BARP11 | ARP3BETA | DKFZp686O24114ARP3 actin-related protein 3 homolog B (yeast)Affinity Capture-MSBioGRID17353931 
ARPC1BARC41 | p40-ARC | p41-ARCactin related protein 2/3 complex, subunit 1B, 41kDa-HPRD9230079 |11162547 
|11721045 
Arp2/3 complex subunits p41 and p16 interactBIND11741539 
ARPC2ARC34 | PNAS-139 | PRO2446 | p34-Arcactin related protein 2/3 complex, subunit 2, 34kDa-HPRD9230079 
ARPC4ARC20 | MGC13544 | p20-Arcactin related protein 2/3 complex, subunit 4, 20kDa-HPRD11162547|12451597 
Two-hybridBioGRID11162547 |12451597 
Arp2/3 complex subunits p20 and p16 interactBIND11741539 
MAPKAPK2MK2mitogen-activated protein kinase-activated protein kinase 2MAPKAPK2 interacts with and phosphorylates the p16-Arc Subunit of the Arp2/3 complexBIND12829704 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)Two-hybridBioGRID10508170 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 5936All SZGR genes in this pathway
BIOCARTA_SALMONELLA_PATHWAY 1310All SZGR genes in this pathway
BIOCARTA_MPR_PATHWAY 3428All SZGR genes in this pathway
BIOCARTA_RHO_PATHWAY 3223All SZGR genes in this pathway
BIOCARTA_CDC42RAC_PATHWAY 1613All SZGR genes in this pathway
BIOCARTA_ACTINY_PATHWAY 2014All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
DORSAM_HOXA9_TARGETS_UP 3525All SZGR genes in this pathway
LU_IL4_SIGNALING 9456All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_DN 169112All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
JIANG_HYPOXIA_CANCER 8352All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_UP 17496All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_DN 10265All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_17 181101All SZGR genes in this pathway
IKEDA_MIR133_TARGETS_UP 4327All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
ALFANO_MYC_TARGETS 239156All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1865871m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5068658711Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-141/200a933939m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-145459465m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-1901481551A,m8hsa-miR-190UGAUAUGUUUGAUAUAUUAGGU
miR-193379385m8hsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
miR-320104110m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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