Gene Page: SAP18

Summary ?
GeneID10284
SymbolSAP18
Synonyms2HOR0202|SAP18P
DescriptionSin3A associated protein 18kDa
ReferenceMIM:602949|HGNC:HGNC:10530|Ensembl:ENSG00000150459|HPRD:04256|Vega:OTTHUMG00000016535
Gene typeprotein-coding
Map location13q12.11
Pascal p-value0.902
Sherlock p-value0.094
Fetal beta-0.838
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg133696241321714458SAP187.86E-10-0.0171.03E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4760510chr1293351595SAP18102840.18trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003714transcription corepressor activityTAS9150135 
GO:0005515protein bindingIPI9150135 |17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006357regulation of transcription from RNA polymerase II promoterTAS9150135 
GO:0006350transcriptionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000118histone deacetylase complexTAS9150135 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATP5LATP5JGATP synthase, H+ transporting, mitochondrial F0 complex, subunit GAffinity Capture-MSBioGRID17353931 
C6orf211DKFZp566I174 | FLJ12910chromosome 6 open reading frame 211Affinity Capture-MSBioGRID17353931 
DDOSTAGE-R1 | KIAA0115 | MGC2191 | OK/SW-cl.45 | OST | OST48 | WBP1dolichyl-diphosphooligosaccharide-protein glycosyltransferaseAffinity Capture-MSBioGRID17353931 
DDX3XDBX | DDX14 | DDX3 | HLP2DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linkedAffinity Capture-MSBioGRID17353931 
EIF3EEIF3-P48 | EIF3S6 | INT6 | eIF3-p46eukaryotic translation initiation factor 3, subunit EAffinity Capture-MSBioGRID17353931 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD9150135 
KIAA1279DKFZp586B0923 | KBP | TTC20KIAA1279Affinity Capture-MSBioGRID17353931 
NOL12FLJ34609 | MGC3731 | Nop25 | dJ37E16.7nucleolar protein 12Two-hybridBioGRID16169070 
NSFSKD2N-ethylmaleimide-sensitive factorAffinity Capture-MSBioGRID17353931 
POLE2DPE2polymerase (DNA directed), epsilon 2 (p59 subunit)Two-hybridBioGRID11872158 
RGS10-regulator of G-protein signaling 10Affinity Capture-MSBioGRID17353931 
RPN2RIBIIR | RPN-II | RPNII | SWP1ribophorin IIAffinity Capture-MSBioGRID17353931 
RPS3AFTE1 | MFTL | MGC23240ribosomal protein S3ATwo-hybridBioGRID16169070 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)Reconstituted ComplexBioGRID9651585 
SUFUPRO1280 | SUFUH | SUFUXLsuppressor of fused homolog (Drosophila)-HPRD,BioGRID11960000 |14611647 
TADA3LADA3 | FLJ20221 | FLJ21329 | hADA3transcriptional adaptor 3 (NGG1 homolog, yeast)-likeTwo-hybridBioGRID16169070 
YARSCMTDIC | TYRRS | YRS | YTStyrosyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID SMAD2 3NUCLEAR PATHWAY 8263All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY 6650All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY 6848All SZGR 2.0 genes in this pathway
PID HEDGEHOG GLI PATHWAY 4835All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431263All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362238All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309199All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLICON 8Q24 DN 4628All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING DN 3524All SZGR 2.0 genes in this pathway
LIANG HEMATOPOIESIS STEM CELL NUMBER SMALL VS HUGE DN 3322All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP 292168All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS UP 4834All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 DN 4929All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION UP 8655All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244151All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0 10772All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G1 6741All SZGR 2.0 genes in this pathway
LIN MELANOMA COPY NUMBER DN 4134All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354216All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285167All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO MERCAPTOPURINE AND HD MTX DN 2518All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442263All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
YUAN ZNF143 PARTNERS 2215All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway