Gene Page: CDSN

Summary ?
GeneID1041
SymbolCDSN
SynonymsHTSS|HTSS1|HYPT2|PSS|PSS1|S
Descriptioncorneodesmosin
ReferenceMIM:602593|HGNC:HGNC:1802|Ensembl:ENSG00000204539|HPRD:03998|Vega:OTTHUMG00000031150
Gene typeprotein-coding
Map location6p21.3
Pascal p-value2.073E-7
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.033 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16869851chr420690056CDSN10410.17trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CKAP20.830.83
MYO3A0.820.48
ATAD20.810.79
C14orf1060.810.73
SGOL20.810.78
CENPC10.790.77
MLF1IP0.790.47
SMARCA50.790.81
SMC20.790.76
RDX0.790.76
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.42-0.64
CXCL14-0.41-0.63
MT-CO2-0.41-0.64
AF347015.2-0.41-0.62
AF347015.8-0.40-0.62
MT-CYB-0.40-0.61
IFI27-0.39-0.63
AF347015.33-0.39-0.58
COX4I2-0.38-0.59
AF347015.15-0.38-0.60

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
GO:0016740transferase activityIEA-
GO:0042803protein homodimerization activityIDA15086562 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008544epidermis developmentTAS9395522 
GO:0008152metabolic processIEA-
GO:0016337cell-cell adhesionIDA11739386 
GO:0030216keratinocyte differentiationNAS8415725 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001533cornified envelopeIDA9395522 
GO:0005576extracellular regionIEA-
GO:0030057desmosomeNAS9395522 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BERENJENO ROCK SIGNALING NOT VIA RHOA UP 2921All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS E DN 2212All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382224All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS MODERATELY DN 11064All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER C 11347All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS DN 8769All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGLL VS IGLK DN 2418All SZGR 2.0 genes in this pathway
PYEON CANCER HEAD AND NECK VS CERVICAL DN 2911All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN 8859All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway