Gene Page: PRMT5

Summary ?
GeneID10419
SymbolPRMT5
SynonymsHRMT1L5|IBP72|JBP1|SKB1|SKB1Hs
Descriptionprotein arginine methyltransferase 5
ReferenceMIM:604045|HGNC:HGNC:10894|Ensembl:ENSG00000100462|HPRD:04955|Vega:OTTHUMG00000028709
Gene typeprotein-coding
Map location14q11.2
Pascal p-value0.002
Sherlock p-value0.087
SupportChromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.047 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
LITAF0.630.65
ST50.620.63
GM2A0.610.65
CHST60.610.60
PRR5L0.610.63
SLC6A90.610.56
CD440.600.59
LAMP10.590.54
CD820.590.59
FAM63A0.590.56
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SATB2-0.33-0.25
TTC9B-0.33-0.34
KLHL1-0.33-0.25
NDUFAF2-0.33-0.41
MEF2C-0.33-0.26
NOX1-0.33-0.35
RPL9-0.33-0.35
AC087071.1-0.32-0.38
GNRHR-0.32-0.36
IER5L-0.31-0.29

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0016740transferase activityIEA-
GO:0008469histone-arginine N-methyltransferase activityIEA-
GO:0008168methyltransferase activityIDA15369763 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000387spliceosomal snRNP biogenesisEXP15130578 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0007088regulation of mitosisTAS9843966 
GO:0008283cell proliferationTAS9843966 
GO:0016568chromatin modificationIEA-
GO:0035246peptidyl-arginine N-methylationIDA15369763 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CAPN1CANP | CANP1 | CANPL1 | muCANP | muCLcalpain 1, (mu/I) large subunitCAPN1 interacts with SKB1.BIND12358155 
CLNS1ACLCI | CLNS1B | IClnchloride channel, nucleotide-sensitive, 1A-HPRD9556550 |11756452 
CLNS1ACLCI | CLNS1B | IClnchloride channel, nucleotide-sensitive, 1AAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9556550 |11713266 
|11756452 
CTDP1CCFDN | FCP1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1FCP1 interacts with PRMT5.BIND15670829 
FBLFIB | FLRN | RNU3IP1fibrillarinAffinity Capture-MSBioGRID14583623 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)-HPRD,BioGRID10531356 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD,BioGRID10531356 
JAK3JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)-HPRD,BioGRID10531356 
MBPMGC99675myelin basic protein-HPRD,BioGRID11152681 
OLA1DKFZp313H1942 | GTPBP9 | PTD004Obg-like ATPase 1Two-hybridBioGRID16169070 
PHYHIPDYRK1AP3 | KIAA0273 | PAHX-AP | PAHXAP1phytanoyl-CoA 2-hydroxylase interacting proteinTwo-hybridBioGRID16169070 
PRMT5HRMT1L5 | IBP72 | JBP1 | SKB1 | SKB1Hsprotein arginine methyltransferase 5SKB1 forms homomeric complexes, including dimers and tetramers.BIND11152681 
PRMT5HRMT1L5 | IBP72 | JBP1 | SKB1 | SKB1Hsprotein arginine methyltransferase 5-HPRD,BioGRID10531356 |11152681 
SNRPD1HsT2456 | SMD1 | SNRPDsmall nuclear ribonucleoprotein D1 polypeptide 16kDa-HPRD,BioGRID11713266 
SNRPD3SMD3small nuclear ribonucleoprotein D3 polypeptide 18kDa-HPRD,BioGRID11713266 
SUPT5HFLJ34157 | SPT5 | SPT5Hsuppressor of Ty 5 homolog (S. cerevisiae)-HPRD,BioGRID12718890 
TYK2JTK1tyrosine kinase 2-HPRD,BioGRID10531356 
WDR77HKMT1069 | MEP50 | MGC2722 | Nbla10071 | RP11-552M11.3 | p44WD repeat domain 77-HPRD,BioGRID11756452 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID E2F PATHWAY 7448All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY 6650All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY 5950All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF NON CODING RNA 4929All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330155All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP 368234All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352225All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316190All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293179All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP 227137All SZGR 2.0 genes in this pathway
FURUKAWA DUSP6 TARGETS PCI35 DN 7440All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS DN 6639All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289166All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN 9867All SZGR 2.0 genes in this pathway
JIANG HYPOXIA CANCER 8352All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307185All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP 188121All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277172All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237159All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway