SZGR2

Summary ?

GeneID	10554
Symbol	AGPAT1
Synonyms	1-AGPAT1\|G15\|LPAAT-alpha\|LPAATA
Description	1-acylglycerol-3-phosphate O-acyltransferase 1
Reference	MIM:603099\|HGNC:HGNC:324\|Ensembl:ENSG00000204310\|HPRD:04372\|Vega:OTTHUMG00000031210
Gene type	protein-coding
Map location	6p21.3
Pascal p-value	1E-12
Sherlock p-value	0.149

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
GSMA_I	Genome scan meta-analysis	Psr: 0.033

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
C17orf28	0.82	0.82
ATP13A2	0.80	0.79
TMEM25	0.80	0.82
SCYL1	0.80	0.80
DBNDD1	0.80	0.80
CAND2	0.79	0.78
SLC5A2	0.79	0.79
DENND4B	0.79	0.79
TAF6	0.79	0.78
REEP2	0.79	0.77

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.21	-0.63	-0.54
AF347015.31	-0.57	-0.48
AF347015.8	-0.57	-0.47
MT-CO2	-0.57	-0.48
GNG11	-0.56	-0.55
MT-ATP8	-0.56	-0.52
AF347015.18	-0.55	-0.47
AF347015.2	-0.54	-0.44
MT-CYB	-0.53	-0.44
NOSTRIN	-0.52	-0.44

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	NAS		9461603
GO:0016740	transferase activity	IEA		-
GO:0008415	acyltransferase activity	IEA		-
GO:0046027	phospholipid:diacylglycerol acyltransferase activity	EXP		9461603
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0008654	phospholipid biosynthetic process	IEA		-
GO:0008152	metabolic process	IEA		-
GO:0006654	phosphatidic acid biosynthetic process	TAS		9461603
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		9461603
GO:0005783	endoplasmic reticulum	TAS		9461603
GO:0016020	membrane	IEA		-
GO:0016021	integral to membrane	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG GLYCEROLIPID METABOLISM	49	26	All SZGR 2.0 genes in this pathway
KEGG GLYCEROPHOSPHOLIPID METABOLISM	77	35	All SZGR 2.0 genes in this pathway
REACTOME TRIGLYCERIDE BIOSYNTHESIS	38	26	All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM	198	112	All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PA	27	14	All SZGR 2.0 genes in this pathway
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	82	39	All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM	120	84	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	478	302	All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	168	115	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP	473	314	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP	368	234	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN DN	172	112	All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 DN	66	38	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER	214	139	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK UP	63	48	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP	249	170	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR GAMMA RADIATION	15	13	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN	195	135	All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE DN	61	39	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF	367	231	All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES	462	273	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN	784	464	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-143	271	277	m8	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-181	147	153	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-328	76	83	1A,m8	hsa-miR-328^brain	CUGGCCCUCUCUGCCCUUCCGU
miR-488	1020	1027	1A,m8	hsa-miR-488	CCCAGAUAAUGGCACUCUCAA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: AGPAT1