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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: FRS3

Summary

GeneID

10817

Symbol

FRS3

Synonyms

FRS2B|FRS2beta|MGC17167|SNT-2|SNT2

Description

fibroblast growth factor receptor substrate 3

Locus tag

RP11-298J23.2

Gene type

protein-coding

Map location

6p21.1

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.033

GSMA_IIE

genome scan meta-analysis (European-ancestry samples)

Psr: 0.04433

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

LSMD1

0.93

0.81

NDUFA2

0.92

0.84

NDUFB7

0.91

0.83

ZNHIT1

0.90

0.77

C19orf70

0.90

0.78

GUK1

0.89

0.74

MRPL54

0.89

0.76

TIMM8B

0.89

0.72

NDUFA13

0.89

0.83

C7orf59

0.89

0.73

Top 10 negatively co-expressed genes

KIF16B

-0.52

-0.62

FNBP1

-0.50

-0.60

UPF2

-0.50

-0.49

GOLGB1

-0.50

-0.55

SOS2

-0.49

-0.54

DYNC1LI2

-0.49

-0.42

AC005035.1

-0.49

-0.59

ZC3H13

-0.49

-0.53

GOLGA4

-0.49

-0.55

MDN1

-0.48

-0.52

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005158

insulin receptor binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007165

signal transduction

TAS

8761293

GO:0008543

fibroblast growth factor receptor signaling pathway

TAS

8761293

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0016020

membrane

IEA

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BMPR2	BMPR-II \| BMPR3 \| BMR2 \| BRK-3 \| FLJ41585 \| FLJ76945 \| PPH1 \| T-ALK	bone morphogenetic protein receptor, type II (serine/threonine kinase)	Affinity Capture-MS	BioGRID	15188402
FGFR1	BFGFR \| CD331 \| CEK \| FGFBR \| FLG \| FLJ99988 \| FLT2 \| HBGFR \| KAL2 \| N-SAM	fibroblast growth factor receptor 1	-	HPRD,BioGRID	9660748 \|10629055
FGFR1		fibroblast growth factor receptor 1	FGFR1 interacts with FRS2-beta.	BIND	10629055
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD	11432792
NTRK1	DKFZp781I14186 \| MTC \| TRK \| TRK1 \| TRKA \| p140-TrkA	neurotrophic tyrosine kinase, receptor, type 1	TrkA interacts with FRS2-beta.	BIND	10629055
PRKCI	DXS1179E \| MGC26534 \| PKCI \| nPKC-iota	protein kinase C, iota	SNT2 interacts with PKC-lambda.	BIND	10383403
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	-	HPRD	11432792

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
PID_SHP2_PATHWAY	58	46	All SZGR genes in this pathway
PID_TRKR_PATHWAY	62	48	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE	127	88	All SZGR genes in this pathway
REACTOME_FRS2_MEDIATED_CASCADE	36	27	All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR	100	74	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR	112	80	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP	973	570	All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP	863	514	All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN	138	92	All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1	467	251	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	239	245	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	239	245	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-27	239	246	1A,m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	239	246	1A,m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-544	101	107	m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.