Gene Page: CHRNA1

Summary ?
GeneID1134
SymbolCHRNA1
SynonymsACHRA|ACHRD|CHRNA|CMS1A|CMS1B|CMS2A|FCCMS|SCCMS
Descriptioncholinergic receptor nicotinic alpha 1 subunit
ReferenceMIM:100690|HGNC:HGNC:1955|Ensembl:ENSG00000138435|HPRD:00007|Vega:OTTHUMG00000132357
Gene typeprotein-coding
Map location2q31.1
Pascal p-value0.1
Fetal beta0.025

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KCNC20.750.75
ANXA60.730.77
PTHLH0.710.75
SIAE0.710.73
SSTR30.700.77
SNX100.700.70
REEP50.690.67
RAB370.690.74
GPR1230.690.66
SGPP20.690.69
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TUBB2B-0.43-0.56
KIAA1949-0.43-0.46
TRAF4-0.42-0.57
FADS2-0.42-0.51
SH3BP2-0.42-0.59
CARHSP1-0.42-0.60
RBMX2-0.42-0.56
TIGD1-0.41-0.43
PDE9A-0.41-0.57
ZNF311-0.41-0.41

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0015464acetylcholine receptor activityTASNeurotransmitter (GO term level: 6)7619526 
GO:0004889nicotinic acetylcholine-activated cation-selective channel activityIMP9221765 
GO:0005216ion channel activityTAS6688857 
GO:0005230extracellular ligand-gated ion channel activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007274neuromuscular synaptic transmissionIMPneuron, Synap (GO term level: 7)9221765 
GO:0007528neuromuscular junction developmentIMPSynap (GO term level: 10)9221765 
GO:0007165signal transductionTAS7619526 
GO:0006811ion transportIEA-
GO:0006936muscle contractionTAS7619526 
GO:0042391regulation of membrane potentialIMP9221765 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0031594neuromuscular junctionIDAneuron, axon, Synap, Neurotransmitter (GO term level: 3)9221765 
GO:0005892nicotinic acetylcholine-gated receptor-channel complexTASNeurotransmitter (GO term level: 9)7619526 
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
BIOCARTA NO1 PATHWAY 3324All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY 3631All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3 PATHWAY 4435All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186155All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137110All SZGR 2.0 genes in this pathway
REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 1613All SZGR 2.0 genes in this pathway
REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 1312All SZGR 2.0 genes in this pathway
REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 1210All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310188All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291176All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP 162116All SZGR 2.0 genes in this pathway
DELASERNA MYOD TARGETS UP 8951All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING 246152All SZGR 2.0 genes in this pathway
BEIER GLIOMA STEM CELL UP 3917All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 5 DN 5031All SZGR 2.0 genes in this pathway