Gene Page: ADH7
Summary ?
| GeneID | 131 |
| Symbol | ADH7 |
| Synonyms | ADH4 |
| Description | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide |
| Reference | MIM:600086|HGNC:HGNC:256|Ensembl:ENSG00000196344|HPRD:02515|Vega:OTTHUMG00000159318 |
| Gene type | protein-coding |
| Map location | 4q23-q24 |
| Pascal p-value | 0.245 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10004753 | chr4 | 99447432 | ADH7 | 131 | 0.08 | cis |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CTSD | 0.85 | 0.82 |
| IPO13 | 0.84 | 0.84 |
| LYNX1 | 0.84 | 0.74 |
| SLC9A1 | 0.83 | 0.76 |
| FAIM2 | 0.82 | 0.79 |
| PDXK | 0.82 | 0.79 |
| RAB11FIP5 | 0.82 | 0.81 |
| OGDHL | 0.82 | 0.71 |
| LPCAT4 | 0.81 | 0.75 |
| CLPTM1 | 0.81 | 0.77 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C9orf46 | -0.48 | -0.56 |
| GTF3C6 | -0.47 | -0.50 |
| EXOSC8 | -0.46 | -0.48 |
| FAM36A | -0.43 | -0.43 |
| RPS3AP47 | -0.41 | -0.50 |
| AC087071.1 | -0.41 | -0.44 |
| C21orf57 | -0.41 | -0.44 |
| RPL13AP22 | -0.41 | -0.65 |
| RBMX2 | -0.41 | -0.47 |
| SPINK8 | -0.41 | -0.48 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG GLYCOLYSIS GLUCONEOGENESIS | 62 | 41 | All SZGR 2.0 genes in this pathway |
| KEGG FATTY ACID METABOLISM | 42 | 29 | All SZGR 2.0 genes in this pathway |
| KEGG TYROSINE METABOLISM | 42 | 30 | All SZGR 2.0 genes in this pathway |
| KEGG RETINOL METABOLISM | 64 | 37 | All SZGR 2.0 genes in this pathway |
| KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 | 70 | 44 | All SZGR 2.0 genes in this pathway |
| KEGG DRUG METABOLISM CYTOCHROME P450 | 72 | 47 | All SZGR 2.0 genes in this pathway |
| REACTOME BIOLOGICAL OXIDATIONS | 139 | 91 | All SZGR 2.0 genes in this pathway |
| REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | 70 | 50 | All SZGR 2.0 genes in this pathway |
| REACTOME ETHANOL OXIDATION | 10 | 9 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS B DN | 8 | 5 | All SZGR 2.0 genes in this pathway |
| RICKMAN HEAD AND NECK CANCER E | 89 | 44 | All SZGR 2.0 genes in this pathway |
| MARCINIAK ER STRESS RESPONSE VIA CHOP | 25 | 17 | All SZGR 2.0 genes in this pathway |
| POS HISTAMINE RESPONSE NETWORK | 32 | 22 | All SZGR 2.0 genes in this pathway |
| YAMASHITA METHYLATED IN PROSTATE CANCER | 57 | 29 | All SZGR 2.0 genes in this pathway |
| CROMER TUMORIGENESIS DN | 51 | 29 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |