Gene Page: CPA1
Summary ?
| GeneID | 1357 |
| Symbol | CPA1 |
| Synonyms | CPA |
| Description | carboxypeptidase A1 |
| Reference | MIM:114850|HGNC:HGNC:2296|Ensembl:ENSG00000091704|HPRD:00269|Vega:OTTHUMG00000157826 |
| Gene type | protein-coding |
| Map location | 7q32 |
| Pascal p-value | 0.004 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Expression | Meta-analysis of gene expression | P value: 2.75 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CYBA | 0.33 | 0.28 |
| FCGRT | 0.30 | 0.27 |
| KRTCAP2 | 0.29 | 0.28 |
| LILRB4 | 0.29 | 0.22 |
| RAB32 | 0.29 | 0.27 |
| FAM176B | 0.28 | 0.24 |
| CTHRC1 | 0.28 | 0.18 |
| PPIC | 0.27 | 0.24 |
| HCST | 0.27 | 0.24 |
| VAMP8 | 0.27 | 0.20 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AC016910.1 | -0.21 | -0.16 |
| OR13J1 | -0.18 | -0.15 |
| KIAA0430 | -0.18 | -0.14 |
| FBXW7 | -0.18 | -0.19 |
| C9orf126 | -0.17 | -0.16 |
| ATRNL1 | -0.17 | -0.15 |
| SPTBN2 | -0.17 | -0.14 |
| KIAA0513 | -0.17 | -0.15 |
| OR52W1 | -0.17 | -0.17 |
| STX1B | -0.17 | -0.15 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004181 | metallocarboxypeptidase activity | TAS | 2920728 | |
| GO:0008270 | zinc ion binding | IEA | - | |
| GO:0008237 | metallopeptidase activity | IEA | - | |
| GO:0008233 | peptidase activity | IEA | - | |
| GO:0046872 | metal ion binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006508 | proteolysis | TAS | 2920728 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005576 | extracellular region | IEA | - | |
| GO:0005615 | extracellular space | IDA | 2920728 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SANSOM APC TARGETS | 212 | 121 | All SZGR 2.0 genes in this pathway |
| LIN MELANOMA COPY NUMBER UP | 73 | 53 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 3D UP | 210 | 124 | All SZGR 2.0 genes in this pathway |
| ACEVEDO METHYLATED IN LIVER CANCER DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
| ROME INSULIN TARGETS IN MUSCLE DN | 204 | 114 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP D | 280 | 158 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
| DELACROIX RARG BOUND MEF | 367 | 231 | All SZGR 2.0 genes in this pathway |