Gene Page: ATF2

Summary
GeneID  1386
Symbol  ATF2
Synonyms  CRE-BP1|CREB2|HB16|MGC111558|TREB7
Description  activating transcription factor 2
See related  HGNC:784|MIM:123811|Ensembl:ENSG00000115966|HPRD:00443|
Locus tag  -
Gene type  protein-coding
Map location  2q32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PLAGL10.660.60
CCND20.640.64
KIAA13240.620.68
PTCHD20.620.44
C1RL0.620.66
EOMES0.610.30
FCGBP0.610.45
EIF2C10.600.65
CTDSP20.600.61
KIAA16140.590.67
Top 10 negatively co-expressed genes
AF347015.31-0.36-0.52
AF347015.21-0.35-0.58
MT-CO2-0.35-0.51
MT-CYB-0.34-0.48
AF347015.8-0.33-0.48
S100A16-0.33-0.48
APOE-0.33-0.48
AF347015.15-0.33-0.46
AF347015.27-0.32-0.47
AF347015.2-0.32-0.45
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0003702RNA polymerase II transcription factor activityTAS10909971 
GO:0003713transcription coactivator activityTAS2529117 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
GO:0043565sequence-specific DNA bindingIEA-
GO:0046983protein dimerization activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9030721 |10878576 
GO:0005622intracellularIEA-
GO:0005624membrane fractionIEA-
GO:0005634nucleusIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATF2CRE-BP1 | CREB2 | HB16 | MGC111558 | TREB7activating transcription factor 2Affinity Capture-WesternBioGRID8027667 
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutatedAn unspecified isoform of ATM interacts with and phosphorylates ATF2.BIND15916964 
CEBPAC/EBP-alpha | CEBPCCAAT/enhancer binding protein (C/EBP), alphaAffinity Capture-Western
Co-localization
Two-hybrid		BioGRID14734562 
-HPRD9139739 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD9139739 
CREB5CRE-BPAcAMP responsive element binding protein 5-HPRD8440710 
CREBBPCBP | KAT3A | RSTSCREB binding proteinAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9786917 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptide-HPRD,BioGRID9685505 
CSNK2A2CK2A2 | CSNK2A1 | FLJ43934casein kinase 2, alpha prime polypeptide-HPRD,BioGRID9685505 
EDF1EDF-1 | MBF1 | MGC9058endothelial differentiation-related factor 1-HPRD,BioGRID10567391 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homolog-HPRD,BioGRID1828107 
GTF2F2BTF4 | RAP30 | TF2F2 | TFIIFgeneral transcription factor IIF, polypeptide 2, 30kDa-HPRD8628277 
HMGA1HMG-R | HMGA1A | HMGIY | MGC12816 | MGC4242 | MGC4854high mobility group AT-hook 1-HPRD,BioGRID10357819 
JDP2JUNDM2Jun dimerization protein 2-HPRD11231009 
JUNAP-1 | AP1 | c-Junjun oncogeneAffinity Capture-Western
in vitro
in vivo
Reconstituted Complex		BioGRID1827203 |2320002 
|8027667 
-HPRD1827203 |2320002 
|9445037 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1Biochemical ActivityBioGRID7737129 
MAPK11P38B | P38BETA2 | PRKM11 | SAPK2 | SAPK2B | p38-2 | p38Betamitogen-activated protein kinase 11As components of the p38-2-ATF2-ATP ternary complex, p38-2 interacts with and phosphorylates ATF2.BIND9235954 
Affinity Capture-Western
Co-localization
Two-hybrid		BioGRID14734562 
MAPK13MGC99536 | PRKM13 | SAPK4 | p38deltamitogen-activated protein kinase 13-HPRD9207191 
Biochemical ActivityBioGRID12244047 
MAPK14CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHAmitogen-activated protein kinase 14An unspecified isoform of p38 interacts with and phosphorylates ATF2.BIND9155018 
An unspecified isoform of p38 interacts with and phosphorylates ATF2.BIND9235954 
p38 phosphorylates ATF2. This interaction was modelled on a demonstrated interaction between human p38 and ATF2 from an unspecified species.BIND15692053 
-HPRD,BioGRID7535770 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3ERK1 interacts with and phosphorylates ATF2.BIND9155018 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8Affinity Capture-Western
Biochemical Activity
Reconstituted Complex		BioGRID7535770 |9207092 
|9405416 |11279118 
-HPRD7737129 |7737130 
MAPK9JNK-55 | JNK2 | JNK2A | JNK2ALPHA | JNK2B | JNK2BETA | PRKM9 | SAPK | p54a | p54aSAPKmitogen-activated protein kinase 9An unspecified isoform of JNK2 interacts with and phosphorylates ATF2.BIND9155018 
MAPKAPK5PRAKmitogen-activated protein kinase-activated protein kinase 5-HPRD9628874 
NBNAT-V1 | AT-V2 | ATV | FLJ10155 | MGC87362 | NBS | NBS1 | P95nibrinATF2 interacts with Nbs1.BIND15916964 
NCOA6AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBPnuclear receptor coactivator 6Affinity Capture-Western
Co-localization
Reconstituted Complex
Two-hybrid		BioGRID14734562 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemiaReconstituted ComplexBioGRID9671405 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1-HPRD,BioGRID1641004 
Rb interacts with ATF2. This interaction was modelled on a demonstrated interaction between Rb from an unspecified species and ATF2 from an unspecified species.BIND11566021 
RUVBL2CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49BRuvB-like 2 (E. coli)-HPRD,BioGRID11713276 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD,BioGRID10085140 
SMAD4DPC4 | JIP | MADH4SMAD family member 4-HPRD,BioGRID10085140 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)-HPRD,BioGRID9488727 
UTF1-undifferentiated embryonic cell transcription factor 1-HPRD,BioGRID9524124 
YY1DELTA | INO80S | NF-E1 | UCRBP | YIN-YANG-1YY1 transcription factorYY1 interacts with ATF-2.BIND7769693 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
BIOCARTA_ALK_PATHWAY 3729All SZGR genes in this pathway
BIOCARTA_AT1R_PATHWAY 3628All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
BIOCARTA_P38MAPK_PATHWAY 4031All SZGR genes in this pathway
BIOCARTA_41BB_PATHWAY 1715All SZGR genes in this pathway
SA_B_CELL_RECEPTOR_COMPLEXES 2420All SZGR genes in this pathway
ST_JNK_MAPK_PATHWAY 4030All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
PID_RHOA_PATHWAY 4533All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_ATF2_PATHWAY 5943All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY 3829All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
PID_RB_1PATHWAY 6546All SZGR genes in this pathway
REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 7454All SZGR genes in this pathway
REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 5037All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS 108All SZGR genes in this pathway
REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES 3024All SZGR genes in this pathway
REACTOME_CIRCADIAN_CLOCK 5340All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 7757All SZGR genes in this pathway
REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 7253All SZGR genes in this pathway
REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 8363All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING 9369All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
RODRIGUES_DCC_TARGETS_DN 12184All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_DN 214133All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
BIDUS_METASTASIS_UP 214134All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_DN 6439All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_DN 7550All SZGR genes in this pathway
YEMELYANOV_GR_TARGETS_DN 108All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
TURJANSKI_MAPK8_AND_MAPK9_TARGETS 87All SZGR genes in this pathway
TURJANSKI_MAPK11_TARGETS 55All SZGR genes in this pathway
TURJANSKI_MAPK14_TARGETS 1010All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_DN 10364All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
YAGI_AML_SURVIVAL 12987All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C2 1815All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_UP 156101All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP 178111All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
BURTON_ADIPOGENESIS_11 5740All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G6 153112All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
NIKOLSKY_OVERCONNECTED_IN_BREAST_CANCER 2219All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S2 11574All SZGR genes in this pathway
ZEMBUTSU_SENSITIVITY_TO_FLUOROURACIL 178All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
ROESSLER_LIVER_CANCER_METASTASIS_UP 10772All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-204/21147541A,m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-2243945m8hsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-261131201A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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