Gene Page: C12orf60
Summary ?
| GeneID | 144608 |
| Symbol | C12orf60 |
| Synonyms | - |
| Description | chromosome 12 open reading frame 60 |
| Reference | HGNC:HGNC:28726|HPRD:11358| |
| Gene type | protein-coding |
| Map location | 12p12.3 |
| Pascal p-value | 0.101 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Nishioka_2013 | Genome-wide DNA methylation analysis | The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg02307482 | 12 | 14956006 | C12orf60 | -0.022 | 0.41 | DMG:Nishioka_2013 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs1610919 | 12 | 14909995 | C12orf60 | ENSG00000182993.3 | 4.32E-7 | 0 | -46511 | gtex_brain_ba24 |
| rs12321339 | 12 | 14910939 | C12orf60 | ENSG00000182993.3 | 7.472E-7 | 0 | -45567 | gtex_brain_ba24 |
| rs34132985 | 12 | 14911863 | C12orf60 | ENSG00000182993.3 | 2.088E-6 | 0 | -44643 | gtex_brain_ba24 |
| rs10772805 | 12 | 14912466 | C12orf60 | ENSG00000182993.3 | 3.69E-7 | 0 | -44040 | gtex_brain_ba24 |
| rs74824908 | 12 | 14912862 | C12orf60 | ENSG00000182993.3 | 1.333E-7 | 0 | -43644 | gtex_brain_ba24 |
| rs247349 | 12 | 14912884 | C12orf60 | ENSG00000182993.3 | 1.078E-7 | 0 | -43622 | gtex_brain_ba24 |
| rs247348 | 12 | 14913468 | C12orf60 | ENSG00000182993.3 | 6.976E-7 | 0 | -43038 | gtex_brain_ba24 |
| rs7955800 | 12 | 14914045 | C12orf60 | ENSG00000182993.3 | 3.341E-7 | 0 | -42461 | gtex_brain_ba24 |
| rs4540876 | 12 | 14914559 | C12orf60 | ENSG00000182993.3 | 1.98E-7 | 0 | -41947 | gtex_brain_ba24 |
| rs247347 | 12 | 14914785 | C12orf60 | ENSG00000182993.3 | 3.172E-7 | 0 | -41721 | gtex_brain_ba24 |
| rs247346 | 12 | 14914886 | C12orf60 | ENSG00000182993.3 | 3.118E-7 | 0 | -41620 | gtex_brain_ba24 |
| rs247345 | 12 | 14917477 | C12orf60 | ENSG00000182993.3 | 1.567E-7 | 0 | -39029 | gtex_brain_ba24 |
| rs11614746 | 12 | 14918756 | C12orf60 | ENSG00000182993.3 | 8.707E-8 | 0 | -37750 | gtex_brain_ba24 |
| rs247325 | 12 | 14921634 | C12orf60 | ENSG00000182993.3 | 1.89E-7 | 0 | -34872 | gtex_brain_ba24 |
| rs247326 | 12 | 14921740 | C12orf60 | ENSG00000182993.3 | 6.448E-8 | 0 | -34766 | gtex_brain_ba24 |
| rs7963704 | 12 | 14921974 | C12orf60 | ENSG00000182993.3 | 6.448E-8 | 0 | -34532 | gtex_brain_ba24 |
| rs10772806 | 12 | 14922305 | C12orf60 | ENSG00000182993.3 | 1.366E-6 | 0 | -34201 | gtex_brain_ba24 |
| rs16910241 | 12 | 14922909 | C12orf60 | ENSG00000182993.3 | 1.884E-7 | 0 | -33597 | gtex_brain_ba24 |
| rs12818627 | 12 | 14923522 | C12orf60 | ENSG00000182993.3 | 6.448E-8 | 0 | -32984 | gtex_brain_ba24 |
| rs12819075 | 12 | 14924228 | C12orf60 | ENSG00000182993.3 | 2.142E-6 | 0 | -32278 | gtex_brain_ba24 |
| rs12231689 | 12 | 14925563 | C12orf60 | ENSG00000182993.3 | 3.473E-7 | 0 | -30943 | gtex_brain_ba24 |
| rs11056182 | 12 | 14925724 | C12orf60 | ENSG00000182993.3 | 2.33E-7 | 0 | -30782 | gtex_brain_ba24 |
| rs2195199 | 12 | 14927994 | C12orf60 | ENSG00000182993.3 | 2.317E-7 | 0 | -28512 | gtex_brain_ba24 |
| rs3789999 | 12 | 14930055 | C12orf60 | ENSG00000182993.3 | 2.317E-7 | 0 | -26451 | gtex_brain_ba24 |
| rs12819291 | 12 | 14932256 | C12orf60 | ENSG00000182993.3 | 9.45E-7 | 0 | -24250 | gtex_brain_ba24 |
| rs7958054 | 12 | 14932821 | C12orf60 | ENSG00000182993.3 | 7.095E-8 | 0 | -23685 | gtex_brain_ba24 |
| rs7970977 | 12 | 14933109 | C12orf60 | ENSG00000182993.3 | 3.389E-8 | 0 | -23397 | gtex_brain_ba24 |
| rs7296334 | 12 | 14933789 | C12orf60 | ENSG00000182993.3 | 2.36E-8 | 0 | -22717 | gtex_brain_ba24 |
| rs12822139 | 12 | 14936158 | C12orf60 | ENSG00000182993.3 | 6.5E-7 | 0 | -20348 | gtex_brain_ba24 |
| rs201190702 | 12 | 14937869 | C12orf60 | ENSG00000182993.3 | 1.516E-10 | 0 | -18637 | gtex_brain_ba24 |
| rs6488712 | 12 | 14939332 | C12orf60 | ENSG00000182993.3 | 1.34E-10 | 0 | -17174 | gtex_brain_ba24 |
| rs6488713 | 12 | 14942916 | C12orf60 | ENSG00000182993.3 | 1.479E-9 | 0 | -13590 | gtex_brain_ba24 |
| rs7314317 | 12 | 14945585 | C12orf60 | ENSG00000182993.3 | 1.731E-7 | 0 | -10921 | gtex_brain_ba24 |
| rs2052325 | 12 | 14948434 | C12orf60 | ENSG00000182993.3 | 9.584E-11 | 0 | -8072 | gtex_brain_ba24 |
| rs71038636 | 12 | 14949624 | C12orf60 | ENSG00000182993.3 | 1.551E-7 | 0 | -6882 | gtex_brain_ba24 |
| rs398044279 | 12 | 14950297 | C12orf60 | ENSG00000182993.3 | 2.208E-7 | 0 | -6209 | gtex_brain_ba24 |
| rs201987535 | 12 | 14950301 | C12orf60 | ENSG00000182993.3 | 2.214E-7 | 0 | -6205 | gtex_brain_ba24 |
| rs1012683 | 12 | 14951050 | C12orf60 | ENSG00000182993.3 | 7.367E-11 | 0 | -5456 | gtex_brain_ba24 |
| rs1012682 | 12 | 14951341 | C12orf60 | ENSG00000182993.3 | 1.728E-7 | 0 | -5165 | gtex_brain_ba24 |
| rs397686933 | 12 | 14954063 | C12orf60 | ENSG00000182993.3 | 3.618E-7 | 0 | -2443 | gtex_brain_ba24 |
| rs7959540 | 12 | 14955702 | C12orf60 | ENSG00000182993.3 | 4.969E-9 | 0 | -804 | gtex_brain_ba24 |
| rs2075268 | 12 | 14956476 | C12orf60 | ENSG00000182993.3 | 3.682E-10 | 0 | -30 | gtex_brain_ba24 |
| rs11830399 | 12 | 14956932 | C12orf60 | ENSG00000182993.3 | 3.001E-10 | 0 | 426 | gtex_brain_ba24 |
| rs12146742 | 12 | 14965332 | C12orf60 | ENSG00000182993.3 | 1.535E-10 | 0 | 8826 | gtex_brain_ba24 |
| rs10846062 | 12 | 14965781 | C12orf60 | ENSG00000182993.3 | 3.02E-10 | 0 | 9275 | gtex_brain_ba24 |
| rs11610238 | 12 | 14975721 | C12orf60 | ENSG00000182993.3 | 3.02E-10 | 0 | 19215 | gtex_brain_ba24 |
| rs10744078 | 12 | 14978535 | C12orf60 | ENSG00000182993.3 | 4.432E-10 | 0 | 22029 | gtex_brain_ba24 |
| rs2193361 | 12 | 14983471 | C12orf60 | ENSG00000182993.3 | 5.366E-10 | 0 | 26965 | gtex_brain_ba24 |
| rs1610919 | 12 | 14909995 | C12orf60 | ENSG00000182993.3 | 3.693E-6 | 0 | -46511 | gtex_brain_putamen_basal |
| rs10772805 | 12 | 14912466 | C12orf60 | ENSG00000182993.3 | 3.603E-6 | 0 | -44040 | gtex_brain_putamen_basal |
| rs74824908 | 12 | 14912862 | C12orf60 | ENSG00000182993.3 | 5.948E-7 | 0 | -43644 | gtex_brain_putamen_basal |
| rs7955800 | 12 | 14914045 | C12orf60 | ENSG00000182993.3 | 3.69E-6 | 0 | -42461 | gtex_brain_putamen_basal |
| rs247347 | 12 | 14914785 | C12orf60 | ENSG00000182993.3 | 3.714E-6 | 0 | -41721 | gtex_brain_putamen_basal |
| rs247346 | 12 | 14914886 | C12orf60 | ENSG00000182993.3 | 3.698E-6 | 0 | -41620 | gtex_brain_putamen_basal |
| rs247345 | 12 | 14917477 | C12orf60 | ENSG00000182993.3 | 1.523E-6 | 0 | -39029 | gtex_brain_putamen_basal |
| rs11614746 | 12 | 14918756 | C12orf60 | ENSG00000182993.3 | 1.836E-7 | 0 | -37750 | gtex_brain_putamen_basal |
| rs247326 | 12 | 14921740 | C12orf60 | ENSG00000182993.3 | 4.524E-7 | 0 | -34766 | gtex_brain_putamen_basal |
| rs7963704 | 12 | 14921974 | C12orf60 | ENSG00000182993.3 | 4.524E-7 | 0 | -34532 | gtex_brain_putamen_basal |
| rs10772806 | 12 | 14922305 | C12orf60 | ENSG00000182993.3 | 8.35E-7 | 0 | -34201 | gtex_brain_putamen_basal |
| rs12818627 | 12 | 14923522 | C12orf60 | ENSG00000182993.3 | 4.52E-7 | 0 | -32984 | gtex_brain_putamen_basal |
| rs12231689 | 12 | 14925563 | C12orf60 | ENSG00000182993.3 | 1.361E-6 | 0 | -30943 | gtex_brain_putamen_basal |
| rs11056182 | 12 | 14925724 | C12orf60 | ENSG00000182993.3 | 4.276E-7 | 0 | -30782 | gtex_brain_putamen_basal |
| rs11056183 | 12 | 14926504 | C12orf60 | ENSG00000182993.3 | 3.571E-6 | 0 | -30002 | gtex_brain_putamen_basal |
| rs2195199 | 12 | 14927994 | C12orf60 | ENSG00000182993.3 | 2.466E-7 | 0 | -28512 | gtex_brain_putamen_basal |
| rs3789999 | 12 | 14930055 | C12orf60 | ENSG00000182993.3 | 2.466E-7 | 0 | -26451 | gtex_brain_putamen_basal |
| rs201190702 | 12 | 14937869 | C12orf60 | ENSG00000182993.3 | 9.276E-7 | 0 | -18637 | gtex_brain_putamen_basal |
| rs6488712 | 12 | 14939332 | C12orf60 | ENSG00000182993.3 | 1.197E-7 | 0 | -17174 | gtex_brain_putamen_basal |
| rs2052325 | 12 | 14948434 | C12orf60 | ENSG00000182993.3 | 1.271E-7 | 0 | -8072 | gtex_brain_putamen_basal |
| rs1012683 | 12 | 14951050 | C12orf60 | ENSG00000182993.3 | 4.528E-8 | 0 | -5456 | gtex_brain_putamen_basal |
| rs7959540 | 12 | 14955702 | C12orf60 | ENSG00000182993.3 | 2.774E-7 | 0 | -804 | gtex_brain_putamen_basal |
| rs2075268 | 12 | 14956476 | C12orf60 | ENSG00000182993.3 | 1.887E-8 | 0 | -30 | gtex_brain_putamen_basal |
| rs11830399 | 12 | 14956932 | C12orf60 | ENSG00000182993.3 | 1.784E-8 | 0 | 426 | gtex_brain_putamen_basal |
| rs398018544 | 12 | 14958051 | C12orf60 | ENSG00000182993.3 | 1.097E-6 | 0 | 1545 | gtex_brain_putamen_basal |
| rs12146742 | 12 | 14965332 | C12orf60 | ENSG00000182993.3 | 2.938E-7 | 0 | 8826 | gtex_brain_putamen_basal |
| rs10846062 | 12 | 14965781 | C12orf60 | ENSG00000182993.3 | 4.172E-8 | 0 | 9275 | gtex_brain_putamen_basal |
| rs7963212 | 12 | 14966165 | C12orf60 | ENSG00000182993.3 | 1.608E-6 | 0 | 9659 | gtex_brain_putamen_basal |
| rs11610238 | 12 | 14975721 | C12orf60 | ENSG00000182993.3 | 5.955E-9 | 0 | 19215 | gtex_brain_putamen_basal |
| rs10744078 | 12 | 14978535 | C12orf60 | ENSG00000182993.3 | 4.327E-9 | 0 | 22029 | gtex_brain_putamen_basal |
| rs561357011 | 12 | 14981556 | C12orf60 | ENSG00000182993.3 | 2.766E-6 | 0 | 25050 | gtex_brain_putamen_basal |
| rs2193361 | 12 | 14983471 | C12orf60 | ENSG00000182993.3 | 9.035E-9 | 0 | 26965 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BENPORATH NANOG TARGETS | 988 | 594 | All SZGR 2.0 genes in this pathway |
| BENPORATH SOX2 TARGETS | 734 | 436 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY E2F4 UNSTIMULATED | 728 | 415 | All SZGR 2.0 genes in this pathway |
| KONDO PROSTATE CANCER HCP WITH H3K27ME3 | 97 | 72 | All SZGR 2.0 genes in this pathway |
| SENGUPTA EBNA1 ANTICORRELATED | 173 | 85 | All SZGR 2.0 genes in this pathway |