Summary ?
Descriptionapoptosis inducing factor, mitochondria associated 3
Gene typeprotein-coding
Map location22q11.21
Pascal p-value0.312
Sherlock p-value0.208
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CNV:YESCopy number variation studiesManual curation
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.031 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005506iron ion bindingIEA-
GO:0008656caspase activator activityIDA15764604 
GO:0009055electron carrier activityIEA-
GO:0016491oxidoreductase activityIEA-
GO:0046872metal ion bindingIEA-
GO:0050660FAD bindingIEA-
GO:00515372 iron, 2 sulfur cluster bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006917induction of apoptosisIDA15764604 
GO:0008635caspase activation via cytochrome cIDA15764604 
GO:0022900electron transport chainIEA-
GO:0045454cell redox homeostasisIEA-
GO:0051882mitochondrial depolarizationIDA15764604 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005743mitochondrial inner membraneIDA15764604 
GO:0005783endoplasmic reticulumIDA15764604 
GO:0005886plasma membraneIDA15764604 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
TONG INTERACT WITH PTTG1 5732All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method