Gene Page: ADRB2

Summary
GeneID  154
Symbol  ADRB2
Synonyms  ADRB2R|ADRBR|B2AR|BAR|BETA2AR
Description  adrenergic, beta-2-, receptor, surface
See related  HGNC:286|MIM:109690|Ensembl:ENSG00000169252|HPRD:00187|
Locus tag  -
Gene type  protein-coding
Map location  5q31-q32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00459 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 4.6166 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MAP20.890.92
DCLK10.880.91
KIF3B0.870.89
MAPRE20.860.89
ABI20.860.90
GNAQ0.860.90
DLG30.860.89
CAMSAP1L10.860.90
PAFAH1B10.860.89
EDEM30.850.88
Top 10 negatively co-expressed genes
FXYD1-0.64-0.69
HSD17B14-0.63-0.68
HIGD1B-0.63-0.71
METRN-0.63-0.72
TLCD1-0.63-0.68
ENHO-0.63-0.75
ACSF2-0.62-0.69
RAB34-0.62-0.69
MT-CO2-0.62-0.68
AF347015.31-0.62-0.67
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0051380norepinephrine bindingIDANeurotransmitter (GO term level: 4)15123695 
GO:0004872receptor activityIEA-
GO:0004941beta2-adrenergic receptor activityIDA15123695 
GO:0005515protein bindingIPI9560162 
GO:0042803protein homodimerization activityIDA15123695 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000187activation of MAPK activityTAS9924018 
GO:0002024diet induced thermogenesisIEA-
GO:0002025vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureIEA-
GO:0002028regulation of sodium ion transportIEA-
GO:0002032desensitization of G-protein coupled receptor protein signaling pathway by arrestinIDA15123695 
GO:0007190activation of adenylate cyclase activityIDA15123695 
GO:0007189G-protein signaling, adenylate cyclase activating pathwayIEA-
GO:0007186G-protein coupled receptor protein signaling pathwayTAS9924018 
GO:0007243protein kinase cascadeTAS10734107 
GO:0008333endosome to lysosome transportTAS9507004 
GO:0009409response to coldIEA-
GO:0006898receptor-mediated endocytosisIDA15123695 
GO:0007171activation of transmembrane receptor protein tyrosine kinase activityTAS10734107 
GO:0040015negative regulation of multicellular organism growthIEA-
GO:0030501positive regulation of bone mineralizationIEA-
GO:0050873brown fat cell differentiationIEA-
GO:0031649heat generationIEA-
GO:0043410positive regulation of MAPKKK cascadeIDA15123695 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0045986negative regulation of smooth muscle contractionIEA-
GO:0045453bone resorptionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043235receptor complexIDANeurotransmitter (GO term level: 4)15123695 
GO:0005624membrane fractionIEA-
GO:0005634nucleusIEA-
GO:0005764lysosomeTAS9507004 
GO:0005768endosomeTAS10734107 
GO:0005886plasma membraneIDA9235896 
GO:0005887integral to plasma membraneTAS9228019 
GO:0016324apical plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADRB2ADRB2R | ADRBR | B2AR | BAR | BETA2ARadrenergic, beta-2-, receptor, surfaceFRETBioGRID11278447 
ADRBK1BARK1 | BETA-ARK1 | FLJ16718 | GRK2adrenergic, beta, receptor kinase 1Affinity Capture-WesternBioGRID11309381 
AKAP12AKAP250 | DKFZp686M0430 | DKFZp686O0331 | FLJ20945 | FLJ97621A kinase (PRKA) anchor protein 12-HPRD,BioGRID9880537 |11309381|11309381 
AKAP5AKAP75 | AKAP79 | H21A kinase (PRKA) anchor protein 5-HPRD10753752 
ARR3ARRXarrestin 3, retinal (X-arrestin)-HPRD11877451 
EIF2B1EIF-2B | EIF-2Balpha | EIF2B | EIF2BA | MGC117409 | MGC125868 | MGC125869eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDaeIF2B-alpha interacts with the cytoplasmic, carboxy-terminus of the beta-2 adrenergic receptor.BIND9235896 
-HPRD,BioGRID9235896 
GNA11GNA-11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)-HPRD7797501 
GNA14-guanine nucleotide binding protein (G protein), alpha 14-HPRD7797501 
GNA15GNA16guanine nucleotide binding protein (G protein), alpha 15 (Gq class)-HPRD7608160 |7797501 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID9830057 
GRK6FLJ32135 | GPRK6G protein-coupled receptor kinase 6-HPRD,BioGRID9819198 
KCNJ3GIRK1 | KGA | KIR3.1potassium inwardly-rectifying channel, subfamily J, member 3Affinity Capture-WesternBioGRID12297500 
KCNJ5CIR | GIRK4 | KATP1 | KIR3.4potassium inwardly-rectifying channel, subfamily J, member 5Affinity Capture-WesternBioGRID12297500 
KCNJ6BIR1 | GIRK2 | KATP2 | KCNJ7 | KIR3.2 | MGC126596 | hiGIRK2potassium inwardly-rectifying channel, subfamily J, member 6-HPRD12297500 
KCNJ9GIRK3 | KIR3.3potassium inwardly-rectifying channel, subfamily J, member 9-HPRD12297500 
OPRD1OPRDopioid receptor, delta 1-HPRD,BioGRID11278447 
PPP3CACALN | CALNA | CALNA1 | CCN1 | CNA1 | PPP2Bprotein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoformCo-fractionationBioGRID9880537 
SLC9A3R1EBP50 | NHERF | NHERF1 | NPHLOP2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1-HPRD,BioGRID9560162 |9671706 
PDZ domain of NHERF binds to the C-terminus of B2AR.BIND9560162 |9671706 
|12621035 
SLC9A3R2E3KARP | MGC104639 | NHE3RF2 | NHERF-2 | NHERF2 | OCTS2 | SIP-1 | SIP1 | TKA-1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2PDZ1 domain of NHERF-2 interacts with the C-terminal tail of beta2-AR.BIND9671706 
-HPRD,BioGRID9671706 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Affinity Capture-WesternBioGRID11013230 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
BIOCARTA_GCR_PATHWAY 2217All SZGR genes in this pathway
BIOCARTA_CFTR_PATHWAY 1211All SZGR genes in this pathway
BIOCARTA_PLCE_PATHWAY 1210All SZGR genes in this pathway
PID_ARF6_TRAFFICKING_PATHWAY 4934All SZGR genes in this pathway
PID_ARF6_PATHWAY 3527All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_AMINE_LIGAND_BINDING_RECEPTORS 3833All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 12182All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
LIU_TARGETS_OF_VMYB_VS_CMYB_DN 4330All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_DN 153100All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_1 4527All SZGR genes in this pathway
SIMBULAN_UV_RESPONSE_NORMAL_DN 3327All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_UP 292168All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_240_MCF10A 5736All SZGR genes in this pathway
MORI_MATURE_B_LYMPHOCYTE_UP 9062All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
ONDER_CDH1_SIGNALING_VIA_CTNNB1 8358All SZGR genes in this pathway
HOEGERKORP_CD44_TARGETS_DIRECT_UP 2721All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_DN 10567All SZGR genes in this pathway
SAGIV_CD24_TARGETS_DN 4626All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN 216143All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP 176110All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_DN 17997All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_0 7654All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
WINZEN_DEGRADED_VIA_KHSRP 10070All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/983003071A,m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-15/16/195/424/497334340m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-200bc/4293153211Ahsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-30-5p5225281Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-381961021Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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