SZGR2

Summary ?

GeneID	154
Symbol	ADRB2
Synonyms	ADRB2R\|ADRBR\|B2AR\|BAR\|BETA2AR
Description	adrenoceptor beta 2
Reference	MIM:109690\|HGNC:HGNC:286\|HPRD:00187\|
Gene type	protein-coding
Map location	5q31-q32
Pascal p-value	0.415
Sherlock p-value	0.076
Fetal beta	-0.561
eGene	Myers' cis & trans
Support	GPCR SIGNALLING

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.0032
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.01718
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.00459
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 2
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 4.6166

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs10994209	chr10	61877705	ADRB2	154		0.15		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MAP2	0.89	0.92
DCLK1	0.88	0.91
KIF3B	0.87	0.89
MAPRE2	0.86	0.89
ABI2	0.86	0.90
GNAQ	0.86	0.90
DLG3	0.86	0.89
CAMSAP1L1	0.86	0.90
PAFAH1B1	0.86	0.89
EDEM3	0.85	0.88

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
FXYD1	-0.64	-0.69
HSD17B14	-0.63	-0.68
HIGD1B	-0.63	-0.71
METRN	-0.63	-0.72
TLCD1	-0.63	-0.68
ENHO	-0.63	-0.75
ACSF2	-0.62	-0.69
RAB34	-0.62	-0.69
MT-CO2	-0.62	-0.68
AF347015.31	-0.62	-0.67

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0051380	norepinephrine binding	IDA	Neurotransmitter (GO term level: 4)	15123695
GO:0004872	receptor activity	IEA		-
GO:0004941	beta2-adrenergic receptor activity	IDA		15123695
GO:0005515	protein binding	IPI		9560162
GO:0042803	protein homodimerization activity	IDA		15123695
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000187	activation of MAPK activity	TAS		9924018
GO:0002024	diet induced thermogenesis	IEA		-
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure	IEA		-
GO:0002028	regulation of sodium ion transport	IEA		-
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	IDA		15123695
GO:0007190	activation of adenylate cyclase activity	IDA		15123695
GO:0007189	G-protein signaling, adenylate cyclase activating pathway	IEA		-
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS		9924018
GO:0007243	protein kinase cascade	TAS		10734107
GO:0008333	endosome to lysosome transport	TAS		9507004
GO:0009409	response to cold	IEA		-
GO:0006898	receptor-mediated endocytosis	IDA		15123695
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	TAS		10734107
GO:0040015	negative regulation of multicellular organism growth	IEA		-
GO:0030501	positive regulation of bone mineralization	IEA		-
GO:0050873	brown fat cell differentiation	IEA		-
GO:0031649	heat generation	IEA		-
GO:0043410	positive regulation of MAPKKK cascade	IDA		15123695
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA		-
GO:0045986	negative regulation of smooth muscle contraction	IEA		-
GO:0045453	bone resorption	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0043235	receptor complex	IDA	Neurotransmitter (GO term level: 4)	15123695
GO:0005624	membrane fraction	IEA		-
GO:0005634	nucleus	IEA		-
GO:0005764	lysosome	TAS		9507004
GO:0005768	endosome	TAS		10734107
GO:0005886	plasma membrane	IDA		9235896
GO:0005887	integral to plasma membrane	TAS		9228019
GO:0016324	apical plasma membrane	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADRB2	ADRB2R \| ADRBR \| B2AR \| BAR \| BETA2AR	adrenergic, beta-2-, receptor, surface	FRET	BioGRID	11278447
ADRBK1	BARK1 \| BETA-ARK1 \| FLJ16718 \| GRK2	adrenergic, beta, receptor kinase 1	Affinity Capture-Western	BioGRID	11309381
AKAP12	AKAP250 \| DKFZp686M0430 \| DKFZp686O0331 \| FLJ20945 \| FLJ97621	A kinase (PRKA) anchor protein 12	-	HPRD,BioGRID	9880537 \|11309381\|11309381
AKAP5	AKAP75 \| AKAP79 \| H21	A kinase (PRKA) anchor protein 5	-	HPRD	10753752
ARR3	ARRX	arrestin 3, retinal (X-arrestin)	-	HPRD	11877451
EIF2B1	EIF-2B \| EIF-2Balpha \| EIF2B \| EIF2BA \| MGC117409 \| MGC125868 \| MGC125869	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	eIF2B-alpha interacts with the cytoplasmic, carboxy-terminus of the beta-2 adrenergic receptor.	BIND	9235896
EIF2B1	EIF-2B \| EIF-2Balpha \| EIF2B \| EIF2BA \| MGC117409 \| MGC125868 \| MGC125869	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	-	HPRD,BioGRID	9235896
GNA11	GNA-11	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	-	HPRD	7797501
GNA14	-	guanine nucleotide binding protein (G protein), alpha 14	-	HPRD	7797501
GNA15	GNA16	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	-	HPRD	7608160 \|7797501
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	9830057
GRK6	FLJ32135 \| GPRK6	G protein-coupled receptor kinase 6	-	HPRD,BioGRID	9819198
KCNJ3	GIRK1 \| KGA \| KIR3.1	potassium inwardly-rectifying channel, subfamily J, member 3	Affinity Capture-Western	BioGRID	12297500
KCNJ5	CIR \| GIRK4 \| KATP1 \| KIR3.4	potassium inwardly-rectifying channel, subfamily J, member 5	Affinity Capture-Western	BioGRID	12297500
KCNJ6	BIR1 \| GIRK2 \| KATP2 \| KCNJ7 \| KIR3.2 \| MGC126596 \| hiGIRK2	potassium inwardly-rectifying channel, subfamily J, member 6	-	HPRD	12297500
KCNJ9	GIRK3 \| KIR3.3	potassium inwardly-rectifying channel, subfamily J, member 9	-	HPRD	12297500
OPRD1	OPRD	opioid receptor, delta 1	-	HPRD,BioGRID	11278447
PPP3CA	CALN \| CALNA \| CALNA1 \| CCN1 \| CNA1 \| PPP2B	protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform	Co-fractionation	BioGRID	9880537
SLC9A3R1	EBP50 \| NHERF \| NHERF1 \| NPHLOP2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	-	HPRD,BioGRID	9560162 \|9671706
SLC9A3R1	EBP50 \| NHERF \| NHERF1 \| NPHLOP2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	PDZ domain of NHERF binds to the C-terminus of B2AR.	BIND	9560162 \|9671706 \|12621035
SLC9A3R2	E3KARP \| MGC104639 \| NHE3RF2 \| NHERF-2 \| NHERF2 \| OCTS2 \| SIP-1 \| SIP1 \| TKA-1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	PDZ1 domain of NHERF-2 interacts with the C-terminal tail of beta2-AR.	BIND	9671706
SLC9A3R2	E3KARP \| MGC104639 \| NHE3RF2 \| NHERF-2 \| NHERF2 \| OCTS2 \| SIP-1 \| SIP1 \| TKA-1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	-	HPRD,BioGRID	9671706
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Affinity Capture-Western	BioGRID	11013230

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CALCIUM SIGNALING PATHWAY	178	134	All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION	272	195	All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS	183	132	All SZGR 2.0 genes in this pathway
BIOCARTA GCR PATHWAY	22	17	All SZGR 2.0 genes in this pathway
BIOCARTA CFTR PATHWAY	12	11	All SZGR 2.0 genes in this pathway
BIOCARTA PLCE PATHWAY	12	10	All SZGR 2.0 genes in this pathway
PID ARF6 TRAFFICKING PATHWAY	49	34	All SZGR 2.0 genes in this pathway
PID ARF6 PATHWAY	35	27	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	305	177	All SZGR 2.0 genes in this pathway
REACTOME AMINE LIGAND BINDING RECEPTORS	38	33	All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING	805	368	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS	121	82	All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING	408	246	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN	320	184	All SZGR 2.0 genes in this pathway
LIU TARGETS OF VMYB VS CMYB DN	43	30	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP	290	177	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN	367	220	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP	380	236	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP	418	263	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN	153	100	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP	612	367	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 1	45	27	All SZGR 2.0 genes in this pathway
SIMBULAN UV RESPONSE NORMAL DN	33	27	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP	292	168	All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 240 MCF10A	57	36	All SZGR 2.0 genes in this pathway
MORI MATURE B LYMPHOCYTE UP	90	62	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN	464	276	All SZGR 2.0 genes in this pathway
ONDER CDH1 SIGNALING VIA CTNNB1	83	58	All SZGR 2.0 genes in this pathway
HOEGERKORP CD44 TARGETS DIRECT UP	27	21	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN	318	220	All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE	261	166	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN	105	67	All SZGR 2.0 genes in this pathway
SAGIV CD24 TARGETS DN	46	26	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN	216	143	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN	457	302	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN	668	419	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP	176	110	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN	179	97	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2	491	319	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 0	76	54	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B	549	316	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
WINZEN DEGRADED VIA KHSRP	100	70	All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF	516	308	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	300	307	1A,m8	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-15/16/195/424/497	334	340	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-200bc/429	315	321	1A	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-30-5p	522	528	1A	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-381	96	102	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ADRB2