Gene Page: DAXX

Summary
GeneID  1616
Symbol  DAXX
Synonyms  BING2|DAP6|EAP1|MGC126245|MGC126246
Description  death-domain associated protein
See related  HGNC:2681|MIM:603186|Ensembl:ENSG00000204209|HPRD:04424|
Locus tag  DADB-159G18.9
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ASPHD10.810.85
CCDC85B0.760.86
RPS6KA40.750.79
GNPTG0.750.82
CYP46A10.750.84
ALKBH60.740.79
PGP0.730.74
CEBPB0.720.78
C17orf890.720.79
NRGN0.720.81
Top 10 negatively co-expressed genes
KIAA1949-0.61-0.57
TUBB2B-0.61-0.59
CCDC123-0.60-0.58
ZNF311-0.60-0.61
THOC2-0.60-0.68
ZNF551-0.60-0.60
FNBP1L-0.60-0.58
AC004017.1-0.59-0.60
TTC27-0.59-0.60
KCNRG-0.59-0.60
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005057receptor signaling protein activityTAS9215629 
GO:0005515protein bindingIEA-
GO:0016564transcription repressor activityIEA-
GO:0031072heat shock protein bindingTAS15572661 
GO:0042802identical protein bindingIPI10698492 
GO:0047485protein N-terminus bindingIPI15572661 
GO:0050681androgen receptor bindingIPI15572661 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000281cytokinesis after mitosisIEA-
GO:0006350transcriptionIEA-
GO:0008625induction of apoptosis via death domain receptorsTAS9215629 
GO:0007257activation of JNK activityTAS9215629 
GO:0006915apoptosisTAS15572661 
GO:0030521androgen receptor signaling pathwayIDA15572661 
GO:0045892negative regulation of transcription, DNA-dependentIDA15572661 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000792heterochromatinIEA-
GO:0005634nucleusIDA15572661 
GO:0005634nucleusIEA-
GO:0005737cytoplasmTAS15572661 
GO:0016605PML bodyIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID15572661 
CENPC1CENP-C | CENPC | MIF2 | hcp-4centromere protein C 1-HPRD,BioGRID9645950 
CFLARCASH | CASP8AP1 | CLARP | Casper | FLAME | FLAME-1 | FLAME1 | FLIP | I-FLICE | MRIT | c-FLIP | c-FLIPL | c-FLIPR | c-FLIPSCASP8 and FADD-like apoptosis regulatorc-FLIP(L) interacts with Daxx.BIND14637155 
CREBBPCBP | KAT3A | RSTSCREB binding proteinCBP interacts with Daxx.BIND11799127 
DAPK3FLJ36473 | ZIP | ZIPKdeath-associated protein kinase 3-HPRD,BioGRID12917339 
ETS1ETS-1 | EWSR2 | FLJ10768v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)-HPRD,BioGRID10698492 
Daxx interacts with p51-ETS1.BIND10698492 
Daxx interacts with p42-ETS1.BIND10698492 
FANCAFA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158Fanconi anemia, complementation group ATwo-hybridBioGRID14499622 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)Reconstituted ComplexBioGRID11483955 
-HPRD9215629 |11193028 
FASLGAPT1LG1 | CD178 | CD95L | FASL | TNFSF6Fas ligand (TNF superfamily, member 6)-HPRD9215629 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD,BioGRID10669754 
HDAC2RPD3 | YAF1histone deacetylase 2Far WesternBioGRID10669754 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3Far WesternBioGRID10669754 
HIPK1KIAA0630 | MGC26642 | MGC33446 | MGC33548 | Myak | Nbak2homeodomain interacting protein kinase 1-HPRD,BioGRID12529400 
HIPK2DKFZp686K02111 | FLJ23711 | PRO0593homeodomain interacting protein kinase 2-HPRD,BioGRID14678985 
MAP3K5ASK1 | MAPKKK5 | MEKK5mitogen-activated protein kinase kinase kinase 5-HPRD,BioGRID9743501 
MCRS1ICP22BP | INO80Q | MCRS2 | MSP58 | P78microspherule protein 1-HPRD,BioGRID11948183 
Daxx interacts with MCRS1 (MSP58).BIND11948183 
MX1IFI-78K | IFI78 | MX | MxAmyxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)in vitro
Two-hybrid		BioGRID11716541 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID12595526 
PAX3CDHS | HUP2 | MGC120381 | MGC120382 | MGC120383 | MGC120384 | MGC134778 | WS1paired box 3-HPRD,BioGRID10393185 
PAX5BSAPpaired box 5-HPRD,BioGRID11799127 
Pax5 interacts with Daxx.BIND11799127 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD10525530 |10669754 
|10684855 |12595526 
Affinity Capture-Western
Co-localization
Two-hybrid		BioGRID10525530 |10669754 
|10684855 |11244500 
SLC2A4GLUT4solute carrier family 2 (facilitated glucose transporter), member 4-HPRD,BioGRID11842083 
SUMO1DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)Daxx interacts with sentrin.BIND11112409 
-HPRD,BioGRID11112409 
Daxx interacts with an unspecified isoform of SUMO1.BIND11948183 
TGFB1CED | DPD1 | TGFB | TGFbetatransforming growth factor, beta 1-HPRD11483955 
TGFB2MGC116892 | TGF-beta2transforming growth factor, beta 2Reconstituted ComplexBioGRID11483955 
TGFBR2AAT3 | FAA3 | LDS1B | LDS2B | MFS2 | RIIC | TAAD2 | TGFR-2 | TGFbeta-RIItransforming growth factor, beta receptor II (70/80kDa)-HPRD11483955 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Daxx interacts with Ubc9.BIND11112409 
Biochemical Activity
Two-hybrid		BioGRID11112409 |18691969 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 5343All SZGR genes in this pathway
BIOCARTA_FAS_PATHWAY 3022All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_KERATINOCYTE_PATHWAY 4638All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
BIOCARTA_P38MAPK_PATHWAY 4031All SZGR genes in this pathway
BIOCARTA_PML_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_HSP27_PATHWAY 1511All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY 6554All SZGR genes in this pathway
PID_HIV_NEF_PATHWAY 3526All SZGR genes in this pathway
PID_P53_REGULATION_PATHWAY 5950All SZGR genes in this pathway
PID_TGFBR_PATHWAY 5538All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
WANG_CLIM2_TARGETS_DN 186114All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_UP 215137All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_VIA_SMAD4_UP 10866All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
INGRAM_SHH_TARGETS_DN 6441All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
AMIT_EGF_RESPONSE_120_HELA 6947All SZGR genes in this pathway
ZEILSTRA_CD44_TARGETS_DN 75All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 6348All SZGR genes in this pathway
HOFMANN_CELL_LYMPHOMA_DN 3929All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
NGUYEN_NOTCH1_TARGETS_DN 8667All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_DN 10563All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_UP 5641All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway


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