SZGR2

Summary ?

GeneID	1634
Symbol	DCN
Synonyms	CSCD\|DSPG2\|PG40\|PGII\|PGS2\|SLRR1B
Description	decorin
Reference	MIM:125255\|HGNC:HGNC:2705\|Ensembl:ENSG00000011465\|HPRD:00501\|
Gene type	protein-coding
Map location	12q21.33
Pascal p-value	0.08
Sherlock p-value	0.01
Fetal beta	-0.769
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0119

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs16825495	chr2	134234401	DCN	1634	0.18	trans
rs2922180	chr3	125280472	DCN	1634	0.02	trans
rs2976809	chr3	125451738	DCN	1634	0.04	trans
rs16894149	chr5	61013724	DCN	1634	0.03	trans
rs816736	chr5	154271947	DCN	1634	0.04	trans
rs6934246	chr6	35154494	DCN	1634	0.1	trans
rs4723002	chr7	30725700	DCN	1634	0.08	trans
rs4723003	chr7	30725740	DCN	1634	0.08	trans
rs2199402	chr8	9201002	DCN	1634	0.04	trans
rs7841407	chr8	9243427	DCN	1634	0.01	trans
rs17134872	chr11	76139845	DCN	1634	0.19	trans
rs11236774	chr11	76234952	DCN	1634	0.19	trans
rs17720221	chr13	75182377	DCN	1634	0.19	trans
rs10149864	chr14	86719683	DCN	1634	0.08	trans
rs2253733	chr15	66299343	DCN	1634	0.17	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AKR1C1	0.92	0.95
STMN2	0.83	0.91
ACAT2	0.82	0.90
TUBA1A	0.82	0.91
TUBB3	0.82	0.91
COTL1	0.82	0.84
CDC42	0.81	0.90
TSPAN2	0.81	0.87
SMAP1	0.80	0.87
PPP3CC	0.80	0.89

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
HLA-F	-0.66	-0.75
HEPN1	-0.62	-0.73
SPARCL1	-0.62	-0.67
AF347015.27	-0.62	-0.81
AF347015.33	-0.62	-0.81
SLC16A11	-0.61	-0.64
AF347015.31	-0.61	-0.77
MT-CO2	-0.60	-0.78
AF347015.8	-0.59	-0.80
TSC22D4	-0.59	-0.72

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0009887	organ morphogenesis	TAS		7961765
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005576	extracellular region	IEA		-
GO:0005578	proteinaceous extracellular matrix	IEA		-
GO:0005634	nucleus	IDA		18029348

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AHSG	A2HS \| AHS \| FETUA \| HSGA	alpha-2-HS-glycoprotein	-	HPRD,BioGRID	12071714
C1QA	-	complement component 1, q subcomponent, A chain	-	HPRD,BioGRID	1431141
COL14A1	UND	collagen, type XIV, alpha 1	-	HPRD,BioGRID	9252349
COL1A1	OI4	collagen, type I, alpha 1	-	HPRD	1468447 \|9675033
COL1A2	OI4	collagen, type I, alpha 2	-	HPRD,BioGRID	1468447 \|2375748 \|9675033
COL2A1	ANFH \| AOM \| COL11A3 \| MGC131516 \| SEDC	collagen, type II, alpha 1	-	HPRD	10382266
COL4A1	arresten	collagen, type IV, alpha 1	-	HPRD	10382266
COL4A2	DKFZp686I14213 \| FLJ22259	collagen, type IV, alpha 2	-	HPRD	10382266
COL4A3	-	collagen, type IV, alpha 3 (Goodpasture antigen)	-	HPRD	10382266
COL4A4	CA44	collagen, type IV, alpha 4	-	HPRD	10382266
COL4A5	ASLN \| ATS \| CA54 \| MGC167109 \| MGC42377	collagen, type IV, alpha 5	-	HPRD	10382266
COL4A6	MGC88184	collagen, type IV, alpha 6	-	HPRD	10382266
COL6A1	OPLL	collagen, type VI, alpha 1	Reconstituted Complex	BioGRID	1544908
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	9988678 \|12105206
ELN	FLJ38671 \| FLJ43523 \| SVAS \| WBS \| WS	elastin	-	HPRD,BioGRID	11723132
FBN1	FBN \| MASS \| MFS1 \| OCTD \| SGS \| WMS	fibrillin 1	-	HPRD	10793130
FLNA	ABP-280 \| ABPX \| DKFZp434P031 \| FLN \| FLN1 \| FMD \| MNS \| NHBP \| OPD \| OPD1 \| OPD2	filamin A, alpha (actin binding protein 280)	-	HPRD,BioGRID	12106908
FN1	CIG \| DKFZp686F10164 \| DKFZp686H0342 \| DKFZp686I1370 \| DKFZp686O13149 \| ED-B \| FINC \| FN \| FNZ \| GFND \| GFND2 \| LETS \| MSF	fibronectin 1	-	HPRD	1468447
PLA2G2A	MOM1 \| PLA2 \| PLA2B \| PLA2L \| PLA2S \| PLAS1 \| sPLA2	phospholipase A2, group IIA (platelets, synovial fluid)	-	HPRD,BioGRID	10747008
SFTPA1B	AC068139.6 \| MGC133365 \| PSAP \| PSPA \| SFTP1 \| SFTPA1	surfactant protein A1B	Reconstituted Complex	BioGRID	12730206
SFTPD	COLEC7 \| PSP-D \| SFTP4 \| SP-D	surfactant protein D	-	HPRD,BioGRID	12730206
TGFB1	CED \| DPD1 \| TGFB \| TGFbeta	transforming growth factor, beta 1	-	HPRD	7638106 \|7798269
TGFB1	CED \| DPD1 \| TGFB \| TGFbeta	transforming growth factor, beta 1	Reconstituted Complex	BioGRID	7798269 \|8093006 \|9675033
TGFB2	MGC116892 \| TGF-beta2	transforming growth factor, beta 2	Reconstituted Complex	BioGRID	9675033
THBS1	THBS \| TSP \| TSP1	thrombospondin 1	-	HPRD	1550960 \|9328841
TNF	DIF \| TNF-alpha \| TNFA \| TNFSF2	tumor necrosis factor (TNF superfamily, member 2)	-	HPRD,BioGRID	12387878
WISP1	CCN4 \| WISP1c \| WISP1i \| WISP1tc	WNT1 inducible signaling pathway protein 1	-	HPRD	11598131

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG TGF BETA SIGNALING PATHWAY	86	64	All SZGR 2.0 genes in this pathway
PID FRA PATHWAY	37	28	All SZGR 2.0 genes in this pathway
REACTOME CS DS DEGRADATION	12	9	All SZGR 2.0 genes in this pathway
REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	21	15	All SZGR 2.0 genes in this pathway
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	49	33	All SZGR 2.0 genes in this pathway
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM	52	33	All SZGR 2.0 genes in this pathway
REACTOME GLYCOSAMINOGLYCAN METABOLISM	111	69	All SZGR 2.0 genes in this pathway
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	25	17	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES	247	154	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR MARKERS DN	20	14	All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP	351	230	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST NORMAL DUCTAL VS LOBULAR DN	7	6	All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL UP	146	99	All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN	199	124	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP	128	95	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP	117	84	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN	232	154	All SZGR 2.0 genes in this pathway
NADERI BREAST CANCER PROGNOSIS DN	18	13	All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF DN	118	78	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA FOREVER UP	19	13	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN	394	258	All SZGR 2.0 genes in this pathway
WONG ENDMETRIUM CANCER DN	82	53	All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP	207	128	All SZGR 2.0 genes in this pathway
KORKOLA TERATOMA	39	25	All SZGR 2.0 genes in this pathway
KORKOLA YOLK SAC TUMOR	62	33	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP	380	213	All SZGR 2.0 genes in this pathway
JOHANSSON BRAIN CANCER EARLY VS LATE DN	45	35	All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS DN	103	59	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4	261	153	All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS UP	127	79	All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 40 MCF10A	32	21	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP	256	159	All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP	71	51	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP	157	105	All SZGR 2.0 genes in this pathway
ABBUD LIF SIGNALING 2 UP	14	13	All SZGR 2.0 genes in this pathway
ABRAHAM ALPC VS MULTIPLE MYELOMA UP	26	22	All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS	126	90	All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP	151	103	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP	390	242	All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF UP	12	10	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS UP	37	27	All SZGR 2.0 genes in this pathway
SIMBULAN PARP1 TARGETS UP	31	23	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP	428	266	All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP	280	183	All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION DN	30	20	All SZGR 2.0 genes in this pathway
JI CARCINOGENESIS BY KRAS AND STK11 DN	17	12	All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6	469	239	All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR DN	191	123	All SZGR 2.0 genes in this pathway
MCCABE HOXC6 TARGETS DN	21	15	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN	564	326	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP	476	285	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN	701	446	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING	510	309	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP	260	174	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS DN	108	64	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN	546	362	All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL DN	127	75	All SZGR 2.0 genes in this pathway
SCHRAETS MLL TARGETS UP	35	21	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
PYEON CANCER HEAD AND NECK VS CERVICAL DN	29	11	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES DN	210	141	All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP	76	46	All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS DN	207	139	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS GROWING	243	155	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT	567	365	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP	504	321	All SZGR 2.0 genes in this pathway
KIM GLIS2 TARGETS UP	84	61	All SZGR 2.0 genes in this pathway
ZHU SKIL TARGETS UP	20	14	All SZGR 2.0 genes in this pathway
BAKKER FOXO3 TARGETS UP	61	41	All SZGR 2.0 genes in this pathway
BRIDEAU IMPRINTED GENES	63	47	All SZGR 2.0 genes in this pathway
ANASTASSIOU CANCER MESENCHYMAL TRANSITION SIGNATURE	64	40	All SZGR 2.0 genes in this pathway
DURAND STROMA NS UP	162	103	All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR	128	73	All SZGR 2.0 genes in this pathway
NABA PROTEOGLYCANS	35	23	All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME	275	148	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-376c	468	474	1A	hsa-miR-376c	AACAUAGAGGAAAUUCCACG
miR-496	470	476	1A	hsa-miR-496	AUUACAUGGCCAAUCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: DCN