Gene Page: POLR3H
Summary ?
| GeneID | 171568 |
| Symbol | POLR3H |
| Synonyms | RPC22.9|RPC8 |
| Description | polymerase (RNA) III subunit H |
| Reference | HGNC:HGNC:30349|Ensembl:ENSG00000100413|HPRD:15157|Vega:OTTHUMG00000150971 |
| Gene type | protein-coding |
| Map location | 22q13.2 |
| Pascal p-value | 0.026 |
| Sherlock p-value | 0.12 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cortex Frontal Cortex BA9 Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| . | 22 | 42144512 | POLR3H | ENSG00000100413.12 | 3.144E-6 | 0.05 | -203902 | gtex_brain_ba24 |
| rs200040074 | 22 | 41785516 | POLR3H | ENSG00000100413.12 | 2.675E-7 | 0.01 | 155094 | gtex_brain_putamen_basal |
| rs199984678 | 22 | 41900710 | POLR3H | ENSG00000100413.12 | 4.336E-6 | 0.01 | 39900 | gtex_brain_putamen_basal |
| rs203320 | 22 | 41913477 | POLR3H | ENSG00000100413.12 | 3.065E-6 | 0.01 | 27133 | gtex_brain_putamen_basal |
| rs203318 | 22 | 41914860 | POLR3H | ENSG00000100413.12 | 3.038E-6 | 0.01 | 25750 | gtex_brain_putamen_basal |
| rs4822032 | 22 | 41925535 | POLR3H | ENSG00000100413.12 | 3.012E-6 | 0.01 | 15075 | gtex_brain_putamen_basal |
| rs6519270 | 22 | 42078666 | POLR3H | ENSG00000100413.12 | 5.636E-6 | 0.01 | -138056 | gtex_brain_putamen_basal |
| . | 22 | 42091027 | POLR3H | ENSG00000100413.12 | 4.875E-6 | 0.01 | -150417 | gtex_brain_putamen_basal |
| rs2097413 | 22 | 42101815 | POLR3H | ENSG00000100413.12 | 3.562E-6 | 0.01 | -161205 | gtex_brain_putamen_basal |
| rs12159188 | 22 | 42121125 | POLR3H | ENSG00000100413.12 | 4.875E-6 | 0.01 | -180515 | gtex_brain_putamen_basal |
| rs200526451 | 22 | 42176584 | POLR3H | ENSG00000100413.12 | 3.582E-6 | 0.01 | -235974 | gtex_brain_putamen_basal |
| rs6002505 | 22 | 42216149 | POLR3H | ENSG00000100413.12 | 4.87E-6 | 0.01 | -275539 | gtex_brain_putamen_basal |
| rs7364123 | 22 | 42216326 | POLR3H | ENSG00000100413.12 | 4.266E-6 | 0.01 | -275716 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PURINE METABOLISM | 159 | 96 | All SZGR 2.0 genes in this pathway |
| KEGG PYRIMIDINE METABOLISM | 98 | 53 | All SZGR 2.0 genes in this pathway |
| KEGG RNA POLYMERASE | 29 | 12 | All SZGR 2.0 genes in this pathway |
| KEGG CYTOSOLIC DNA SENSING PATHWAY | 56 | 44 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | 23 | 12 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL III TRANSCRIPTION | 33 | 18 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSCRIPTION | 210 | 127 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | 122 | 80 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | 26 | 13 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL III TRANSCRIPTION TERMINATION | 19 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL III CHAIN ELONGATION | 17 | 8 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
| MANTOVANI VIRAL GPCR SIGNALING UP | 86 | 54 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER WITH H3K27ME3 DN | 228 | 114 | All SZGR 2.0 genes in this pathway |
| ZHANG BREAST CANCER PROGENITORS UP | 425 | 253 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN | 374 | 217 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | All SZGR 2.0 genes in this pathway |
| DELACROIX RARG BOUND MEF | 367 | 231 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |