Gene Page: DYNC1I2
Summary ?
GeneID | 1781 |
Symbol | DYNC1I2 |
Synonyms | DIC74|DNCI2|IC2 |
Description | dynein cytoplasmic 1 intermediate chain 2 |
Reference | MIM:603331|HGNC:HGNC:2964|HPRD:04512| |
Gene type | protein-coding |
Map location | 2q31.1 |
Pascal p-value | 1.327E-5 |
Sherlock p-value | 0.048 |
Fetal beta | 2.121 |
eGene | Cerebellar Hemisphere Cerebellum Myers' cis & trans |
Support | G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs1076773 | chr1 | 37136422 | DYNC1I2 | 1781 | 0.16 | trans | ||
rs6829546 | chr4 | 12587664 | DYNC1I2 | 1781 | 0.07 | trans | ||
rs6448932 | chr4 | 12595798 | DYNC1I2 | 1781 | 0.14 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
SSFA2 | 0.87 | 0.87 |
TLN1 | 0.87 | 0.86 |
ITPKB | 0.86 | 0.87 |
KANK1 | 0.86 | 0.84 |
TJP1 | 0.86 | 0.82 |
FGFR2 | 0.85 | 0.84 |
OTUD7B | 0.84 | 0.82 |
SASH1 | 0.84 | 0.82 |
MTMR10 | 0.84 | 0.82 |
ZCCHC24 | 0.84 | 0.84 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
MED19 | -0.49 | -0.53 |
ZNF32 | -0.47 | -0.54 |
COMMD3 | -0.47 | -0.53 |
NR2C2AP | -0.47 | -0.51 |
AC011491.1 | -0.47 | -0.49 |
BID | -0.47 | -0.50 |
DCTN3 | -0.47 | -0.48 |
NDUFAF2 | -0.46 | -0.53 |
POLB | -0.46 | -0.51 |
C3orf54 | -0.45 | -0.48 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG VASOPRESSIN REGULATED WATER REABSORPTION | 44 | 30 | All SZGR 2.0 genes in this pathway |
REACTOME CELL CYCLE | 421 | 253 | All SZGR 2.0 genes in this pathway |
REACTOME MHC CLASS II ANTIGEN PRESENTATION | 91 | 61 | All SZGR 2.0 genes in this pathway |
REACTOME CELL CYCLE MITOTIC | 325 | 185 | All SZGR 2.0 genes in this pathway |
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | 66 | 43 | All SZGR 2.0 genes in this pathway |
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | 59 | 38 | All SZGR 2.0 genes in this pathway |
REACTOME MITOTIC G2 G2 M PHASES | 81 | 50 | All SZGR 2.0 genes in this pathway |
REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
REACTOME ADAPTIVE IMMUNE SYSTEM | 539 | 350 | All SZGR 2.0 genes in this pathway |
LINDGREN BLADDER CANCER CLUSTER 3 DN | 229 | 142 | All SZGR 2.0 genes in this pathway |
LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP | 555 | 346 | All SZGR 2.0 genes in this pathway |
BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 14HR DN | 298 | 200 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
CHANDRAN METASTASIS DN | 306 | 191 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 1HR DN | 222 | 147 | All SZGR 2.0 genes in this pathway |
PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |