Gene Page: EGR2

Summary
GeneID  1959
Symbol  EGR2
Synonyms  AT591|CMT1D|CMT4E|DKFZp686J1957|FLJ14547|KROX20
Description  early growth response 2 (Krox-20 homolog, Drosophila)
See related  HGNC:3239|MIM:129010|Ensembl:ENSG00000122877|HPRD:00551|
Locus tag  -
Gene type  protein-coding
Map location  10q21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PMPCB0.890.85
UQCRC20.880.85
DNAJA20.880.84
YPEL50.880.87
POLR3F0.870.85
BTBD100.870.87
SARS0.870.86
TMEM490.870.84
COPS30.860.83
RHOT10.860.83
Top 10 negatively co-expressed genes
AF347015.2-0.67-0.59
AF347015.26-0.67-0.59
MT-CO2-0.66-0.57
AF347015.8-0.65-0.57
MT-CYB-0.65-0.57
AF347015.15-0.64-0.57
AF347015.33-0.63-0.57
AF347015.21-0.63-0.55
AF347015.18-0.63-0.63
AF347015.31-0.62-0.56
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIDA14532282 
GO:0005515protein bindingIPI14532282 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentTASBrain (GO term level: 7)9537424 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0007422peripheral nervous system developmentTAS9537424 
GO:0007638mechanosensory behaviorIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACP5MGC117378 | TRAPacid phosphatase 5, tartrate resistantTwo-hybridBioGRID16169070 
FASLGAPT1LG1 | CD178 | CD95L | FASL | TNFSF6Fas ligand (TNF superfamily, member 6)EGR2 interacts with p-FasL (FasL promoter).BIND11909874 
HCFC1CFF | HCF-1 | HCF1 | HFC1 | MGC70925 | VCAFhost cell factor C1 (VP16-accessory protein)-HPRD,BioGRID14532282 
MED313110004H13Rik | CGI-125 | FLJ27436 | FLJ36714 | Soh1mediator complex subunit 31Two-hybridBioGRID16169070 
NFATC1MGC138448 | NF-ATC | NFAT2 | NFATcnuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1Reconstituted ComplexBioGRID12560487 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_VIP_PATHWAY 2926All SZGR genes in this pathway
ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 4535All SZGR genes in this pathway
PID_IL4_2PATHWAY 6543All SZGR genes in this pathway
PID_NFAT_TFPATHWAY 4739All SZGR genes in this pathway
PID_TAP63_PATHWAY 5440All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 7253All SZGR genes in this pathway
ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_UP 183119All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_DN 244153All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP 185126All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
NAGASHIMA_EGF_SIGNALING_UP 5840All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP 6446All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
GESERICK_TERT_TARGETS_DN 2116All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_3_4WK_UP 214144All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_UP 271175All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_DN 7954All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP 169127All SZGR genes in this pathway
MCBRYAN_TERMINAL_END_BUD_UP 1212All SZGR genes in this pathway
CHASSOT_SKIN_WOUND 109All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
PEREZ_TP53_AND_TP63_TARGETS 205145All SZGR genes in this pathway
DIRMEIER_LMP1_RESPONSE_EARLY 6648All SZGR genes in this pathway
DAWSON_METHYLATED_IN_LYMPHOMA_TCL1 5945All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
KIM_GERMINAL_CENTER_T_HELPER_UP 6642All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 6647All SZGR genes in this pathway
ZHANG_TARGETS_OF_EWSR1_FLI1_FUSION 8868All SZGR genes in this pathway
GALINDO_IMMUNE_RESPONSE_TO_ENTEROTOXIN 8567All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN 7748All SZGR genes in this pathway
STAEGE_EWING_FAMILY_TUMOR 3322All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_UP 3627All SZGR genes in this pathway
SARTIPY_NORMAL_AT_INSULIN_RESISTANCE_UP 3427All SZGR genes in this pathway
ABE_VEGFA_TARGETS 2015All SZGR genes in this pathway
SAFFORD_T_LYMPHOCYTE_ANERGY 8754All SZGR genes in this pathway
ABE_VEGFA_TARGETS_30MIN 2921All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
WANG_LSD1_TARGETS_DN 3930All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP 210124All SZGR genes in this pathway
CHENG_IMPRINTED_BY_ESTRADIOL 11068All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
LIN_NPAS4_TARGETS_DN 6848All SZGR genes in this pathway
VILIMAS_NOTCH1_TARGETS_UP 5241All SZGR genes in this pathway
SEKI_INFLAMMATORY_RESPONSE_LPS_UP 7756All SZGR genes in this pathway
HUNSBERGER_EXERCISE_REGULATED_GENES 3126All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_D 6844All SZGR genes in this pathway
LEE_RECENT_THYMIC_EMIGRANT 227128All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MIKKELSEN_DEDIFFERENTIATED_STATE_DN 77All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN 3726All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_UP 5638All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP 163111All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_1HR_UP 3426All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
PHONG_TNF_TARGETS_UP 6343All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
HECKER_IFNB1_TARGETS 9554All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1907913m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506858864m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1375795861A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-141/200a102910351Ahsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-142-3p7379m8hsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-1504014081A,m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-17-5p/20/93.mr/106/519.d4584651A,m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-224101910261A,m8hsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-25/32/92/363/367612618m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-324-5p8268321Ahsa-miR-324-5pCGCAUCCCCUAGGGCAUUGGUGU
miR-34b9629681Ahsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-377864870m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.