SZGR2

Summary ?

GeneID	2002
Symbol	ELK1
Synonyms	-
Description	ELK1, ETS transcription factor
Reference	MIM:311040\|HGNC:HGNC:3321\|Ensembl:ENSG00000126767\|HPRD:02407\|Vega:OTTHUMG00000021452
Gene type	protein-coding
Map location	Xp11.2
Sherlock p-value	0.234
DEG p-value	DEG:Sanders_2014:DS1_p=0.162:DS1_beta=0.019600:DS2_p=3.20e-01:DS2_beta=0.050:DS2_FDR=5.73e-01
Fetal beta	-0.472

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
DEG:Sanders_2013	Microarray	Whole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Expression	Meta-analysis of gene expression	P value: 1.879
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SMG5	0.87	0.88
FLII	0.85	0.86
GRIPAP1	0.85	0.85
RECQL5	0.84	0.85
XPC	0.84	0.85
FAM160B2	0.84	0.86
MYBBP1A	0.84	0.85
FKBP15	0.84	0.84
DDX27	0.83	0.85
POLG	0.83	0.84

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.21	-0.70	-0.68
AF347015.31	-0.65	-0.60
C1orf54	-0.64	-0.62
CLEC2B	-0.61	-0.62
MT-CO2	-0.60	-0.56
GNG11	-0.59	-0.59
AF347015.27	-0.58	-0.56
IFI27	-0.58	-0.53
VAMP5	-0.58	-0.57
HIGD1B	-0.58	-0.54

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003700	transcription factor activity	IDA		14970218
GO:0003700	transcription factor activity	IEA		-
GO:0005515	protein binding	IPI		16291755 \|16533805
GO:0043565	sequence-specific DNA binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006350	transcription	IEA		-
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA		14970218
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IC		14970218
GO:0005634	nucleus	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	-	HPRD	11313879
CEBPB	C/EBP-beta \| CRP2 \| IL6DBP \| LAP \| MGC32080 \| NF-IL6 \| TCF5	CCAAT/enhancer binding protein (C/EBP), beta	-	HPRD	1547942
EP300	KAT3B \| p300	E1A binding protein p300	Affinity Capture-Western Phenotypic Enhancement Reconstituted Complex	BioGRID	12514134
EWSR1	EWS	Ewing sarcoma breakpoint region 1	Reconstituted Complex	BioGRID	9010223
FLI1	EWSR2 \| SIC-1	Friend leukemia virus integration 1	Reconstituted Complex	BioGRID	9010223
FOS	AP-1 \| C-FOS	v-fos FBJ murine osteosarcoma viral oncogene homolog	-	HPRD	7540136
FOSL1	FRA \| FRA1 \| fra-1	FOS-like antigen 1	Elk1 interacts with the region of the FRA-1 promoter containing the SRE and ATF sites.	BIND	15806162
GRB10	GRB-IR \| Grb-10 \| IRBP \| KIAA0207 \| MEG1 \| RSS	growth factor receptor-bound protein 10	-	HPRD	8798570
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD	8798570
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	mitogen-activated protein kinase 1	Mapk1 (p42Mapk) phosphorylates Elk1 at Ser383.	BIND	15782123
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	mitogen-activated protein kinase 1	-	HPRD	8208531 \|8586671
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	mitogen-activated protein kinase 1	Biochemical Activity Reconstituted Complex	BioGRID	8586671 \|12594221
MAPK11	P38B \| P38BETA2 \| PRKM11 \| SAPK2 \| SAPK2B \| p38-2 \| p38Beta	mitogen-activated protein kinase 11	p38-2 interacts with and phosphorylates Elk1.	BIND	9235954
MAPK14	CSBP1 \| CSBP2 \| CSPB1 \| EXIP \| Mxi2 \| PRKM14 \| PRKM15 \| RK \| SAPK2A \| p38 \| p38ALPHA	mitogen-activated protein kinase 14	Elk-1 is phosphorylated by an unspecified isoform of p38 MAPK. This interaction was modeled on a demonstrated interaction between human Elk-1 and p38 MAPK from an unspecified species.	BIND	9130707
MAPK14	CSBP1 \| CSBP2 \| CSPB1 \| EXIP \| Mxi2 \| PRKM14 \| PRKM15 \| RK \| SAPK2A \| p38 \| p38ALPHA	mitogen-activated protein kinase 14	-	HPRD	8622669
MAPK14	CSBP1 \| CSBP2 \| CSPB1 \| EXIP \| Mxi2 \| PRKM14 \| PRKM15 \| RK \| SAPK2A \| p38 \| p38ALPHA	mitogen-activated protein kinase 14	An unspecified isoform of p38 interacts with and phosphorylates Elk-1.	BIND	9155018
MAPK3	ERK1 \| HS44KDAP \| HUMKER1A \| MGC20180 \| P44ERK1 \| P44MAPK \| PRKM3	mitogen-activated protein kinase 3	Elk-1 is phosphorylated by ERK-1. This interaction was modeled on a demonstrated interaction between human Elk-1 and ERK-1 from an unspecified species.	BIND	9130707
MAPK3	ERK1 \| HS44KDAP \| HUMKER1A \| MGC20180 \| P44ERK1 \| P44MAPK \| PRKM3	mitogen-activated protein kinase 3	-	HPRD	8208531 \|12473660
MAPK3	ERK1 \| HS44KDAP \| HUMKER1A \| MGC20180 \| P44ERK1 \| P44MAPK \| PRKM3	mitogen-activated protein kinase 3	Mapk3 (p44Mapk) phosphorylates Elk1 at Ser383.	BIND	15782123
MAPK3	ERK1 \| HS44KDAP \| HUMKER1A \| MGC20180 \| P44ERK1 \| P44MAPK \| PRKM3	mitogen-activated protein kinase 3	ERK1 interacts with and phosphorylates Elk1. This interaction was modelled on a demonstrated interaction between rat ERK1 and human Elk1.	BIND	9235954
MAPK3	ERK1 \| HS44KDAP \| HUMKER1A \| MGC20180 \| P44ERK1 \| P44MAPK \| PRKM3	mitogen-activated protein kinase 3	Elk-1 is phosphorylated by ERK-1. This interaction was modeled on a demonstrated interaction between human Elk-1 and ERK-1 from an unspecified species.	BIND	9020136
MAPK3	ERK1 \| HS44KDAP \| HUMKER1A \| MGC20180 \| P44ERK1 \| P44MAPK \| PRKM3	mitogen-activated protein kinase 3	ERK1 interacts with and phosphorylates Elk-1.	BIND	9155018
MAPK3	ERK1 \| HS44KDAP \| HUMKER1A \| MGC20180 \| P44ERK1 \| P44MAPK \| PRKM3	mitogen-activated protein kinase 3	Erk1 phosphorylates Elk-1. This interaction was modeled on a demonstrated interaction between Erk1 and Elk-1 from an unspecified species.	BIND	10431817
MAPK8	JNK \| JNK1 \| JNK1A2 \| JNK21B1/2 \| PRKM8 \| SAPK1	mitogen-activated protein kinase 8	An unspecified isoform of JNK1 interacts with and phosphorylates Elk1.	BIND	9235954
MAPK8	JNK \| JNK1 \| JNK1A2 \| JNK21B1/2 \| PRKM8 \| SAPK1	mitogen-activated protein kinase 8	Biochemical Activity	BioGRID	8586671
MAPK8	JNK \| JNK1 \| JNK1A2 \| JNK21B1/2 \| PRKM8 \| SAPK1	mitogen-activated protein kinase 8	Elk-1 is phosphorylated by JNK-1. This interaction was modeled on a demonstrated interaction between human Elk-1 and JNK-1 from an unspecified species.	BIND	9020136
MAPK9	JNK-55 \| JNK2 \| JNK2A \| JNK2ALPHA \| JNK2B \| JNK2BETA \| PRKM9 \| SAPK \| p54a \| p54aSAPK	mitogen-activated protein kinase 9	An unspecified isoform of JNK2 interacts with and phosphorylates Elk-1.	BIND	9155018
PIAS2	MGC102682 \| MIZ1 \| PIASX \| PIASX-ALPHA \| PIASX-BETA \| SIZ2 \| ZMIZ4 \| miz	protein inhibitor of activated STAT, 2	ELK1 interacts with PIAS2a (PIASX-alpha).	BIND	15920481
SNCA	MGC110988 \| NACP \| PARK1 \| PARK4 \| PD1	synuclein, alpha (non A4 component of amyloid precursor)	-	HPRD	11279280
SRF	MCM1	serum response factor (c-fos serum response element-binding transcription factor)	-	HPRD,BioGRID	9010223
STK16	FLJ39635 \| KRCT \| MPSK \| PKL12 \| TSF1	serine/threonine kinase 16	-	HPRD,BioGRID	10947953

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG ERBB SIGNALING PATHWAY	87	71	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY	137	103	All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY	101	77	All SZGR 2.0 genes in this pathway
KEGG PRION DISEASES	35	28	All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION	72	56	All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER	52	45	All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY	36	28	All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY	37	28	All SZGR 2.0 genes in this pathway
BIOCARTA EGF PATHWAY	31	25	All SZGR 2.0 genes in this pathway
BIOCARTA EPO PATHWAY	19	13	All SZGR 2.0 genes in this pathway
BIOCARTA ERK PATHWAY	28	22	All SZGR 2.0 genes in this pathway
BIOCARTA FCER1 PATHWAY	41	30	All SZGR 2.0 genes in this pathway
BIOCARTA FMLP PATHWAY	39	29	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1 PATHWAY	21	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL2 PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL6 PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA INSULIN PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY	87	68	All SZGR 2.0 genes in this pathway
BIOCARTA NGF PATHWAY	18	13	All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY	40	31	All SZGR 2.0 genes in this pathway
BIOCARTA PDGF PATHWAY	32	25	All SZGR 2.0 genes in this pathway
BIOCARTA RAS PATHWAY	23	20	All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY	37	30	All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY	37	31	All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY	49	37	All SZGR 2.0 genes in this pathway
BIOCARTA TOLL PATHWAY	37	31	All SZGR 2.0 genes in this pathway
ST DIFFERENTIATION PATHWAY IN PC12 CELLS	45	35	All SZGR 2.0 genes in this pathway
SA B CELL RECEPTOR COMPLEXES	24	20	All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY	37	28	All SZGR 2.0 genes in this pathway
SA TRKA RECEPTOR	17	15	All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY	65	50	All SZGR 2.0 genes in this pathway
PID HIF2PATHWAY	34	29	All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY	50	41	All SZGR 2.0 genes in this pathway
PID TCR RAS PATHWAY	14	14	All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY	105	78	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID PDGFRA PATHWAY	22	18	All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY	24	19	All SZGR 2.0 genes in this pathway
PID MAPK TRK PATHWAY	34	31	All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY	65	56	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING	74	54	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	24	20	All SZGR 2.0 genes in this pathway
REACTOME ERK MAPK TARGETS	21	17	All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE	50	37	All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	30	24	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	77	57	All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	72	53	All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	83	63	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING	93	69	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES	118	84	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER UP	96	57	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP	552	347	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP	211	136	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
TURJANSKI MAPK1 AND MAPK2 TARGETS	12	10	All SZGR 2.0 genes in this pathway
TURJANSKI MAPK8 AND MAPK9 TARGETS	8	7	All SZGR 2.0 genes in this pathway
TURJANSKI MAPK11 TARGETS	5	5	All SZGR 2.0 genes in this pathway
TURJANSKI MAPK14 TARGETS	10	10	All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK	101	73	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN	289	166	All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC	182	116	All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND H2O2	39	29	All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP	244	165	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C4	18	12	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER DN	33	22	All SZGR 2.0 genes in this pathway
HUNSBERGER EXERCISE REGULATED GENES	31	26	All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM HIGH RISK UP	10	7	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-135	678	684	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	678	684	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-136	729	735	m8	hsa-miR-136	ACUCCAUUUGUUUUGAUGAUGGA
miR-150	541	547	m8	hsa-miR-150	UCUCCCAACCCUUGUACCAGUG
miR-150	541	547	m8	hsa-miR-150	UCUCCCAACCCUUGUACCAGUG
miR-185	49	56	1A,m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-219	365	371	m8	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-326	1251	1258	1A,m8	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-382	191	197	m8	hsa-miR-382^brain	GAAGUUGUUCGUGGUGGAUUCG
miR-539	405	412	1A,m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ELK1