Gene Page: ESRRG
Summary ?
| GeneID | 2104 |
| Symbol | ESRRG |
| Synonyms | ERR3|ERRgamma|NR3B3 |
| Description | estrogen related receptor gamma |
| Reference | MIM:602969|HGNC:HGNC:3474|Ensembl:ENSG00000196482|HPRD:04274|Vega:OTTHUMG00000037025 |
| Gene type | protein-coding |
| Map location | 1q41 |
| Sherlock p-value | 0.708 |
| Fetal beta | -1.477 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg12636169 | 1 | 217309970 | ESRRG | 3.353E-4 | 0.55 | 0.041 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4854547 | chr2 | 69342532 | ESRRG | 2104 | 0.13 | trans | ||
| rs7644174 | chr3 | 112722325 | ESRRG | 2104 | 0.15 | trans | ||
| rs17302994 | chr5 | 14299830 | ESRRG | 2104 | 0.14 | trans | ||
| rs6578951 | chr11 | 8321127 | ESRRG | 2104 | 0.03 | trans | ||
| rs17825002 | chr14 | 94887676 | ESRRG | 2104 | 0.17 | trans | ||
| rs12101606 | chr15 | 79264036 | ESRRG | 2104 | 0.09 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SPRED2 | 0.85 | 0.83 |
| LMTK2 | 0.83 | 0.79 |
| SHC3 | 0.82 | 0.85 |
| AP000751.3 | 0.82 | 0.77 |
| ATP2B2 | 0.82 | 0.81 |
| PLCB1 | 0.81 | 0.79 |
| PER2 | 0.81 | 0.79 |
| ARHGEF3 | 0.81 | 0.78 |
| DLGAP1 | 0.81 | 0.76 |
| KIAA1045 | 0.80 | 0.75 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| DBI | -0.43 | -0.44 |
| RAB34 | -0.40 | -0.39 |
| AC011475.1 | -0.39 | -0.39 |
| C1orf54 | -0.38 | -0.37 |
| AF347015.21 | -0.38 | -0.29 |
| C1orf61 | -0.38 | -0.40 |
| AL050337.1 | -0.37 | -0.40 |
| RP9P | -0.37 | -0.44 |
| FAM159B | -0.37 | -0.52 |
| AL139819.3 | -0.37 | -0.35 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 352 | 181 | All SZGR 2.0 genes in this pathway |
| REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | 49 | 36 | All SZGR 2.0 genes in this pathway |
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP | 408 | 247 | All SZGR 2.0 genes in this pathway |
| THUM SYSTOLIC HEART FAILURE DN | 244 | 147 | All SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER EARLY DN | 367 | 220 | All SZGR 2.0 genes in this pathway |
| DELYS THYROID CANCER DN | 232 | 154 | All SZGR 2.0 genes in this pathway |
| CONCANNON APOPTOSIS BY EPOXOMICIN DN | 172 | 112 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER APOCRINE VS BASAL | 330 | 217 | All SZGR 2.0 genes in this pathway |
| MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP | 176 | 111 | All SZGR 2.0 genes in this pathway |
| FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN | 546 | 351 | All SZGR 2.0 genes in this pathway |
| BECKER TAMOXIFEN RESISTANCE DN | 52 | 37 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY NO BLOOD DN | 150 | 93 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY DN | 145 | 88 | All SZGR 2.0 genes in this pathway |
| XU GH1 EXOGENOUS TARGETS DN | 120 | 69 | All SZGR 2.0 genes in this pathway |
| LEIN PONS MARKERS | 89 | 59 | All SZGR 2.0 genes in this pathway |
| LEIN MEDULLA MARKERS | 81 | 48 | All SZGR 2.0 genes in this pathway |
| RIGGINS TAMOXIFEN RESISTANCE UP | 66 | 44 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL DN | 701 | 446 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | All SZGR 2.0 genes in this pathway |
| CLIMENT BREAST CANCER COPY NUMBER UP | 23 | 20 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS CTNNB1 UP | 176 | 110 | All SZGR 2.0 genes in this pathway |
| ZHAN MULTIPLE MYELOMA MF DN | 41 | 28 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS DN | 553 | 343 | All SZGR 2.0 genes in this pathway |
| TERAO AOX4 TARGETS SKIN DN | 27 | 15 | All SZGR 2.0 genes in this pathway |
| IKEDA MIR30 TARGETS DN | 27 | 24 | All SZGR 2.0 genes in this pathway |