SZGR2

Summary ?

GeneID	2138
Symbol	EYA1
Synonyms	BOP\|BOR\|BOS1\|OFC1
Description	EYA transcriptional coactivator and phosphatase 1
Reference	MIM:601653\|HGNC:HGNC:3519\|Ensembl:ENSG00000104313\|HPRD:03388\|Vega:OTTHUMG00000149894
Gene type	protein-coding
Map location	8q13.3
Pascal p-value	0.53
Fetal beta	0.387
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs2890901	chr9	10112765	EYA1	2138	0.17	trans
rs10958892	chr9	10125117	EYA1	2138	0.01	trans
rs10958896	chr9	10126894	EYA1	2138	0.01	trans
rs10958899	chr9	10128700	EYA1	2138	0.01	trans
rs10958907	chr9	10131580	EYA1	2138	0	trans
rs1322159	chr9	10132695	EYA1	2138	0.12	trans
rs10958910	chr9	10134759	EYA1	2138	0.03	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
PRLR	0.97	0.15
CP	0.97	0.62
KCNJ13	0.96	0.28
CLIC6	0.95	0.47
SLC5A5	0.94	0.38
SLC13A4	0.91	0.30
ABCA4	0.90	0.40
FOLR1	0.88	0.33
RBM47	0.87	0.16
TRPV4	0.87	0.22

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
NR2C2AP	-0.12	-0.54
OLFM2	-0.12	-0.43
PLEKHO1	-0.12	-0.52
ALKBH2	-0.12	-0.54
ASGR1	-0.12	-0.41
STMN1	-0.12	-0.45
AC009133.1	-0.11	-0.46
RFC2	-0.11	-0.45
TUBB2B	-0.11	-0.53
MPND	-0.11	-0.35

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000287	magnesium ion binding	IEA		-
GO:0003824	catalytic activity	IEA		-
GO:0005515	protein binding	IEA		-
GO:0004725	protein tyrosine phosphatase activity	IEA		-
GO:0016787	hydrolase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0045664	regulation of neuron differentiation	IEA	neuron, neurogenesis (GO term level: 9)	-
GO:0001657	ureteric bud development	IEA		-
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006350	transcription	IEA		-
GO:0006470	protein amino acid dephosphorylation	IEA		-
GO:0009887	organ morphogenesis	IEA		-
GO:0009653	anatomical structure morphogenesis	TAS		9020840
GO:0008152	metabolic process	IEA		-
GO:0007605	sensory perception of sound	TAS		9020840
GO:0007389	pattern specification process	IEA		-
GO:0007275	multicellular organismal development	IEA		-
GO:0043066	negative regulation of apoptosis	IEA		-
GO:0042472	inner ear morphogenesis	IEA		-
GO:0045165	cell fate commitment	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IEA		-
GO:0005737	cytoplasm	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP	255	177	All SZGR 2.0 genes in this pathway
DAVICIONI RHABDOMYOSARCOMA PAX FOXO1 FUSION UP	64	37	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN	329	219	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL UP	83	51	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q12 Q22 AMPLICON	132	82	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN	163	115	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA UP	98	64	All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP	262	186	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN	261	183	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP	428	266	All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER WITH H3K27ME3	196	93	All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1	91	75	All SZGR 2.0 genes in this pathway
BREDEMEYER RAG SIGNALING VIA ATM NOT VIA NFKB DN	38	23	All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN	264	159	All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS UP	153	107	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR	27	12	All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2	356	214	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN	244	157	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4	227	149	All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN	308	187	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	1810	1816	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
				hsa-miR-101	UACAGUACUGUGAUAACUGAAG
				hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-124.1	849	855	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	848	855	1A,m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	848	855	1A,m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	200	206	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	200	206	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-144	1810	1816	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-15/16/195/424/497	1646	1653	1A,m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-219	705	712	1A,m8	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-23	326	332	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	326	332	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-27	282	288	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
				hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
				hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
				hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-323	326	332	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-369-3p	1081	1088	1A,m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	1082	1088	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-493-5p	691	697	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-503	1647	1653	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-543	229	235	m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: EYA1