SZGR2

Summary ?

GeneID	23136
Symbol	EPB41L3
Synonyms	4.1B\|DAL-1\|DAL1
Description	erythrocyte membrane protein band 4.1-like 3
Reference	MIM:605331\|HGNC:HGNC:3380\|Ensembl:ENSG00000082397\|HPRD:05622\|Vega:OTTHUMG00000131562
Gene type	protein-coding
Map location	18p11.32
Pascal p-value	0.138
Sherlock p-value	0.944
Fetal beta	-1.693
DMG	1 (# studies)
Support	STRUCTURAL PLASTICITY G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg06459104	18	5456880	EPB41L3	4.183E-4	-0.688	0.044	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
FLCN	0.90	0.90
DPP9	0.89	0.89
ZNF335	0.89	0.90
FAM160B2	0.89	0.91
FLII	0.89	0.90
POLG	0.89	0.89
ATP8B2	0.89	0.92
PLEKHM1	0.88	0.89
SYVN1	0.88	0.88
HMGXB3	0.87	0.88

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.21	-0.73	-0.74
AF347015.31	-0.67	-0.65
GNG11	-0.65	-0.66
C1orf54	-0.63	-0.68
MT-CO2	-0.63	-0.62
AF347015.27	-0.63	-0.63
AF347015.8	-0.62	-0.61
AL050337.1	-0.59	-0.61
MT-CYB	-0.59	-0.57
MT-ATP8	-0.58	-0.65

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003779	actin binding	IEA		-
GO:0005488	binding	IEA		-
GO:0005198	structural molecule activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0008150	biological_process	ND		-
GO:0030866	cortical actin cytoskeleton organization	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005856	cytoskeleton	IEA		-
GO:0005737	cytoplasm	IEA		-
GO:0005911	cell-cell junction	IDA		12234973
GO:0005886	plasma membrane	NAS		9892180
GO:0019898	extrinsic to membrane	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CADM1	BL2 \| DKFZp686F1789 \| IGSF4 \| IGSF4A \| MGC149785 \| MGC51880 \| NECL2 \| Necl-2 \| RA175 \| ST17 \| SYNCAM \| TSLC1 \| sTSLC-1 \| sgIGSF \| synCAM1	cell adhesion molecule 1	-	HPRD,BioGRID	12234973
CD44	CDW44 \| CSPG8 \| ECMR-III \| HCELL \| IN \| LHR \| MC56 \| MDU2 \| MDU3 \| MGC10468 \| MIC4 \| MUTCH-I \| Pgp1	CD44 molecule (Indian blood group)	EPB41L3 (DAL-1) interacts with an unspecified isoform of CD44.	BIND	15688033
CEP152	KIAA0912	centrosomal protein 152kDa	-	HPRD	12421765
CNTNAP2	AUTS15 \| CASPR2 \| CDFE \| DKFZp781D1846 \| NRXN4	contactin associated protein-like 2	-	HPRD,BioGRID	12542678
MBIP	-	MAP3K12 binding inhibitory protein 1	Two-hybrid	BioGRID	16189514
PLA2G2A	MOM1 \| PLA2 \| PLA2B \| PLA2L \| PLA2S \| PLAS1 \| sPLA2	phospholipase A2, group IIA (platelets, synovial fluid)	EPB41L3 (DAL-1) interacts with an unspecified isoform of PLA2G2A (14-3-3).	BIND	15688033
SMYD2	HSKM-B \| KMT3C \| MGC119305 \| ZMYND14	SET and MYND domain containing 2	Affinity Capture-MS	BioGRID	17353931
SPTBN1	ELF \| SPTB2 \| betaSpII	spectrin, beta, non-erythrocytic 1	Reconstituted Complex	BioGRID	15116094
SPTBN1	ELF \| SPTB2 \| betaSpII	spectrin, beta, non-erythrocytic 1	EPB41L3 (DAL-1) interacts with an unspecified isoform of SPTBN1 (beta-II-spectrin).	BIND	15688033
YWHAB	GW128 \| HS1 \| KCIP-1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	-	HPRD,BioGRID	11996670
YWHAG	14-3-3GAMMA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	-	HPRD,BioGRID	11996670
YWHAH	YWHA1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	-	HPRD,BioGRID	11996670
YWHAQ	14-3-3 \| 1C5 \| HS1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	Affinity Capture-MS	BioGRID	17353931
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	Affinity Capture-MS	BioGRID	17353931

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG TIGHT JUNCTION	134	86	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL UP	44	25	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL UP	73	50	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST CARCINOMA DUCTAL VS LOBULAR UP	21	14	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN	116	79	All SZGR 2.0 genes in this pathway
PEPPER CHRONIC LYMPHOCYTIC LEUKEMIA UP	33	28	All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN	232	139	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN	536	332	All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN	291	176	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN	232	154	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP	207	128	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS	355	243	All SZGR 2.0 genes in this pathway
PEREZ TP53 AND TP63 TARGETS	205	145	All SZGR 2.0 genes in this pathway
LUI THYROID CANCER CLUSTER 2	42	31	All SZGR 2.0 genes in this pathway
DACOSTA ERCC3 ALLELE XPCS VS TTD UP	28	19	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS DN	47	33	All SZGR 2.0 genes in this pathway
MANTOVANI VIRAL GPCR SIGNALING UP	86	54	All SZGR 2.0 genes in this pathway
FRASOR RESPONSE TO ESTRADIOL UP	37	28	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION UP	140	83	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP	183	111	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP	249	170	All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP	175	116	All SZGR 2.0 genes in this pathway
ULE SPLICING VIA NOVA2	43	38	All SZGR 2.0 genes in this pathway
MCDOWELL ACUTE LUNG INJURY DN	48	33	All SZGR 2.0 genes in this pathway
TRACEY RESISTANCE TO IFNA2 DN	32	23	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP	783	442	All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS	245	148	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING	510	309	All SZGR 2.0 genes in this pathway
GRADE COLON VS RECTAL CANCER DN	56	36	All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP	198	128	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN	315	201	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP	418	282	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP	408	276	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN	442	275	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE DN	204	114	All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 5	33	24	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2	491	319	All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3	435	318	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA NEURAL	129	85	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP	364	236	All SZGR 2.0 genes in this pathway
BOUDOUKHA BOUND BY IGF2BP2	111	59	All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL DN	146	88	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	938	944	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-223	89	95	m8	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-26	874	881	1A,m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	874	881	1A,m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-96	493	499	m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: EPB41L3