Gene Page: PIK3R5

Summary ?
GeneID23533
SymbolPIK3R5
SynonymsF730038I15Rik|FOAP-2|P101-PI3K|p101
Descriptionphosphoinositide-3-kinase regulatory subunit 5
ReferenceMIM:611317|HGNC:HGNC:30035|Ensembl:ENSG00000141506|HPRD:11433|
Gene typeprotein-coding
Map location17p13.1
Pascal p-value0.902
Fetal beta-0.547

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KCNAB20.870.72
LGI30.870.85
CPEB10.860.85
P2RX60.860.77
MLXIPL0.860.83
KIAA07480.850.76
ARHGAP90.850.83
SYT120.840.83
ETS20.840.76
SNAP250.840.61
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PKN1-0.50-0.61
BCL7C-0.50-0.62
TUBB2B-0.50-0.66
NKIRAS2-0.50-0.54
KIAA1949-0.50-0.59
YBX1-0.49-0.68
TRAF4-0.48-0.64
SH2B2-0.48-0.64
MARCKSL1-0.48-0.56
HN1-0.48-0.55

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ERBB SIGNALING PATHWAY 8771All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 7656All SZGR 2.0 genes in this pathway
KEGG MTOR SIGNALING PATHWAY 5240All SZGR 2.0 genes in this pathway
KEGG APOPTOSIS 8862All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 7653All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201138All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 10288All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY 155105All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 13792All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 10889All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY 7556All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY 7958All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 9771All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 11878All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126103All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216144All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137103All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION 8659All SZGR 2.0 genes in this pathway
KEGG TYPE II DIABETES MELLITUS 4741All SZGR 2.0 genes in this pathway
KEGG ALDOSTERONE REGULATED SODIUM REABSORPTION 4229All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER 6247All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA 7060All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER 7056All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER 5245All SZGR 2.0 genes in this pathway
KEGG GLIOMA 6556All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER 8975All SZGR 2.0 genes in this pathway
KEGG MELANOMA 7157All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA 7359All SZGR 2.0 genes in this pathway
KEGG ACUTE MYELOID LEUKEMIA 6047All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER 8467All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER 5447All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES 6754All SZGR 2.0 genes in this pathway
SIG CHEMOTAXIS 4537All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN B LYMPHOCYTES 3631All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY 5743All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 10278All SZGR 2.0 genes in this pathway
PID PI3KCI PATHWAY 4940All SZGR 2.0 genes in this pathway
PID EPHA FWDPATHWAY 3429All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129103All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198112All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 3123All SZGR 2.0 genes in this pathway
REACTOME PI METABOLISM 4834All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME GPVI MEDIATED ACTIVATION CASCADE 3125All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 2515All SZGR 2.0 genes in this pathway
REACTOME G PROTEIN BETA GAMMA SIGNALLING 2818All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER ADVANCED VS EARLY UP 175120All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226132All SZGR 2.0 genes in this pathway
ODONNELL METASTASIS UP 8258All SZGR 2.0 genes in this pathway
XU HGF TARGETS REPRESSED BY AKT1 DN 9558All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
DURAND STROMA NS UP 162103All SZGR 2.0 genes in this pathway