Gene Page: PLEKHG4
Summary ?
| GeneID | 25894 |
| Symbol | PLEKHG4 |
| Synonyms | ARHGEF44|PRTPHN1|SCA4 |
| Description | pleckstrin homology and RhoGEF domain containing G4 |
| Reference | MIM:609526|HGNC:HGNC:24501|Ensembl:ENSG00000196155|HPRD:10890|Vega:OTTHUMG00000172936 |
| Gene type | protein-coding |
| Map location | 16q22.1 |
| Pascal p-value | 0.012 |
| eGene | Cerebellum |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Expression | Meta-analysis of gene expression | P value: 1.418 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZBTB45 | 0.94 | 0.95 |
| ALKBH4 | 0.93 | 0.93 |
| MAP1S | 0.93 | 0.93 |
| ARMC5 | 0.91 | 0.92 |
| EPN1 | 0.90 | 0.91 |
| TMEM115 | 0.90 | 0.91 |
| INTS5 | 0.90 | 0.91 |
| HPS6 | 0.90 | 0.90 |
| TBC1D10B | 0.89 | 0.90 |
| DHX30 | 0.89 | 0.89 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.75 | -0.74 |
| AF347015.31 | -0.75 | -0.74 |
| AF347015.8 | -0.73 | -0.75 |
| AF347015.33 | -0.73 | -0.72 |
| MT-CYB | -0.72 | -0.73 |
| AF347015.27 | -0.72 | -0.73 |
| AF347015.21 | -0.72 | -0.76 |
| AF347015.15 | -0.69 | -0.71 |
| AF347015.2 | -0.68 | -0.68 |
| NOSTRIN | -0.68 | -0.71 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | - | |
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0008219 | cell death | IEA | - | |
| GO:0035023 | regulation of Rho protein signal transduction | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005622 | intracellular | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SENESE HDAC1 AND HDAC2 TARGETS DN | 232 | 139 | All SZGR 2.0 genes in this pathway |
| LANDEMAINE LUNG METASTASIS | 21 | 12 | All SZGR 2.0 genes in this pathway |
| CERVERA SDHB TARGETS 1 UP | 118 | 66 | All SZGR 2.0 genes in this pathway |
| NAKAMURA METASTASIS | 47 | 28 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC ICP WITH H3 UNMETHYLATED | 24 | 15 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K27ME3 | 42 | 27 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS CONFLUENT | 567 | 365 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
| DURAND STROMA S UP | 297 | 194 | All SZGR 2.0 genes in this pathway |