SZGR2

Summary ?

GeneID	26059
Symbol	ERC2
Synonyms	CAST\|CAST1\|ELKSL\|SPBC110\|Spc110
Description	ELKS/RAB6-interacting/CAST family member 2
Reference	HGNC:HGNC:31922\|Ensembl:ENSG00000187672\|HPRD:10810\|Vega:OTTHUMG00000158390
Gene type	protein-coding
Map location	3p14.3
Pascal p-value	0.028
Sherlock p-value	0.972
Fetal beta	-0.553
eGene	Cerebellar Hemisphere Cerebellum
Support	PROTEIN CLUSTERING G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:GWAScat	Genome-wide Association Studies	This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 3

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		12923177
GO:0005515	protein binding	ISS		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0042734	presynaptic membrane	ISS	neuron, axon, Synap (GO term level: 5)	-
GO:0019717	synaptosome	IEA	Synap, Brain (GO term level: 7)	-
GO:0030426	growth cone	ISS	axon, dendrite (GO term level: 5)	-
GO:0045202	synapse	IEA	neuron, Synap, Neurotransmitter, Glial (GO term level: 2)	-
GO:0005856	cytoskeleton	IEA		-
GO:0005737	cytoplasm	IEA		-
GO:0030054	cell junction	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
BROWNE HCMV INFECTION 20HR UP	240	152	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-103/107	2685	2691	m8	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	2685	2691	m8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-124.1	1465	1471	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-128	2348	2355	1A,m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	2348	2355	1A,m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-135	1603	1609	1A	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	1603	1609	1A	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-140	712	718	m8	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-141/200a	2610	2616	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	2610	2616	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-15/16/195/424/497	1492	1498	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-182	725	731	m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-218	1191	1197	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-24	1601	1607	1A	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-25/32/92/363/367	1575	1581	m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-26	2019	2026	1A,m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	2019	2026	1A,m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-299-5p	711	717	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-299-5p	711	717	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-30-5p	2336	2342	1A	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-31	724	730	1A	hsa-miR-31	AGGCAAGAUGCUGGCAUAGCUG
miR-329	753	759	m8	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-361	87	94	1A,m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-381	547	553	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-455	776	782	m8	hsa-miR-455	UAUGUGCCUUUGGACUACAUCG
miR-485-3p	2938	2944	m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-490	685	691	m8	hsa-miR-490	CAACCUGGAGGACUCCAUGCUG
miR-493-5p	2910	2916	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-500	1574	1580	1A	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG
miR-9	13	19	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-96	2116	2122	m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ERC2