Gene Page: CHIA

Summary ?
GeneID27159
SymbolCHIA
SynonymsAMCASE|CHIT2|TSA1902
Descriptionchitinase, acidic
ReferenceMIM:606080|HGNC:HGNC:17432|Ensembl:ENSG00000134216|HPRD:09355|Vega:OTTHUMG00000011165
Gene typeprotein-coding
Map location1p13.2
Pascal p-value0.411
Fetal beta-0.283

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.0235 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003824catalytic activityIEA-
GO:0003796lysozyme activityNAS11085997 
GO:0005529sugar bindingNAS11085997 
GO:0004568chitinase activityIDA11085997 
GO:0004568chitinase activityIEA-
GO:0004568chitinase activityNAS10548734 
GO:0008061chitin bindingIEA-
GO:0008061chitin bindingTAS11085997 
GO:0043169cation bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000272polysaccharide catabolic processIEA-
GO:0001101response to acidTAS11085997 
GO:0006037cell wall chitin metabolic processTAS11085997 
GO:0006032chitin catabolic processIEA-
GO:0006032chitin catabolic processNAS11085997 
GO:0005975carbohydrate metabolic processIEA-
GO:0009620response to fungusTAS11085997 
GO:0008152metabolic processIEA-
GO:0007586digestionNAS11085997 
GO:0006955immune responseNAS11085997 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIC11085997 
GO:0005737cytoplasmNAS10548734 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM 4430All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS UP 170107All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
TAVAZOIE METASTASIS 10868All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
MAEKAWA ATF2 TARGETS 2419All SZGR 2.0 genes in this pathway