SZGR2

Summary ?

GeneID	302
Symbol	ANXA2
Synonyms	ANX2\|ANX2L4\|CAL1H\|HEL-S-270\|LIP2\|LPC2\|LPC2D\|P36\|PAP-IV
Description	annexin A2
Reference	MIM:151740\|HGNC:HGNC:537\|Ensembl:ENSG00000182718\|HPRD:01061\|Vega:OTTHUMG00000132763
Gene type	protein-coding
Map location	15q22.2
Pascal p-value	0.17
Sherlock p-value	5.752E-5
Fetal beta	0.823
eGene	Myers' cis & trans
Support	STRUCTURAL PLASTICITY CompositeSet Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0983

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs17131472	chr1	91962966	ANXA2	302	0.01	trans
rs546975	chr1	91963738	ANXA2	302	0.05	trans
rs2839839	chr2	51691483	ANXA2	302	0.15	trans
rs2922180	chr3	125280472	ANXA2	302	0	trans
rs2971271	chr3	125450402	ANXA2	302	0.06	trans
rs2976809	chr3	125451738	ANXA2	302	8.874E-4	trans
rs10050805	chr5	30805352	ANXA2	302	0	trans
rs837115	chr5	40736290	ANXA2	302	0.14	trans
rs16894149	chr5	61013724	ANXA2	302	0.02	trans
rs6449550	chr5	61034312	ANXA2	302	0.03	trans
rs17135501	chr6	2704474	ANXA2	302	0.03	trans
rs17135521	chr6	2707631	ANXA2	302	0.03	trans
snp_a-1787926		0	ANXA2	302	0.03	trans
rs6934246	chr6	35154494	ANXA2	302	0.03	trans
rs6455226	chr6	67930295	ANXA2	302	0	trans
rs2199402	chr8	9201002	ANXA2	302	0	trans
rs2169384	chr8	9216985	ANXA2	302	0.12	trans
rs1381350	chr8	9217194	ANXA2	302	0.18	trans
rs7841407	chr8	9243427	ANXA2	302	2.439E-4	trans
rs680372	chr8	36999626	ANXA2	302	0.09	trans
rs2061799	chr9	97795003	ANXA2	302	0	trans
rs4743989	chr9	97859191	ANXA2	302	0.13	trans
rs4514358	chr10	43861923	ANXA2	302	0.03	trans
rs7081666	chr10	47673800	ANXA2	302	0.02	trans
rs1159612	chr10	85329057	ANXA2	302	0.11	trans
rs11199997	chr10	85456823	ANXA2	302	0.18	trans
rs11820030	chr11	76133564	ANXA2	302	0.13	trans
rs17134872	chr11	76139845	ANXA2	302	0.08	trans
rs11236774	chr11	76234952	ANXA2	302	0.08	trans
rs11049036	chr12	27650292	ANXA2	302	0.1	trans
rs10879027	chr12	70237156	ANXA2	302	0.06	trans
rs9529974	chr13	72821935	ANXA2	302	0.12	trans
rs17073665	chr13	81541961	ANXA2	302	0.01	trans
rs11840833	chr13	94378306	ANXA2	302	0.08	trans
rs10149864	chr14	86719683	ANXA2	302	0.09	trans
rs17244419	chr14	97171074	ANXA2	302	0.18	trans
rs4987765	chr18	60905021	ANXA2	302	0.13	trans
rs11873703	chr18	61448702	ANXA2	302	0	trans
rs6095741	chr20	48666589	ANXA2	302	1.433E-5	trans
rs17191809	chr21	36444778	ANXA2	302	0.19	trans
rs5991662	chrX	43335796	ANXA2	302	3.85E-4	trans
rs1545676	chrX	93530472	ANXA2	302	0.01	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004859	phospholipase inhibitor activity	IEA		-
GO:0004859	phospholipase inhibitor activity	TAS		3013422
GO:0005544	calcium-dependent phospholipid binding	IEA		-
GO:0005509	calcium ion binding	IEA		-
GO:0008092	cytoskeletal protein binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0001501	skeletal system development	TAS		7961821
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005576	extracellular region	IEA		-
GO:0005604	basement membrane	IEA		-
GO:0005625	soluble fraction	TAS		7961821
GO:0005886	plasma membrane	TAS		10809787
GO:0042470	melanosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APOH	B2G1 \| BG	apolipoprotein H (beta-2-glycoprotein I)	-	HPRD,BioGRID	10809787
CD99	MIC2 \| MIC2X \| MIC2Y	CD99 molecule	CD99 interacts with ANXA2.	BIND	15388255
CEACAM1	BGP \| BGP1 \| BGPI	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	-	HPRD,BioGRID	14522961
CTSB	APPS \| CPSB	cathepsin B	-	HPRD,BioGRID	10777578
DYSF	FER1L1 \| FLJ00175 \| FLJ90168 \| LGMD2B	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	-	HPRD	14506282
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	7510700
LGALS13	GAL13 \| PLAC8 \| PP13	lectin, galactoside-binding, soluble, 13	-	HPRD	15009185
LYPLA1	APT-1 \| LPL1 \| LYSOPLA	lysophospholipase I	-	HPRD,BioGRID	1531641
PCNA	MGC8367	proliferating cell nuclear antigen	-	HPRD,BioGRID	9228079 \|12171929
PHB	PHB1	prohibitin	-	HPRD,BioGRID	12628297
PLA1A	PS-PLA1 \| PSPLA1	phospholipase A1 member A	-	HPRD,BioGRID	1531641
PLAT	DKFZp686I03148 \| T-PA \| TPA	plasminogen activator, tissue	-	HPRD,BioGRID	11978811 \|12468550
PLG	DKFZp779M0222	plasminogen	-	HPRD	10077593
PPM1B	MGC21657 \| PP2C-beta-X \| PP2CB \| PP2CBETA \| PPC2BETAX	protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform	Affinity Capture-MS	BioGRID	17353931
S100A10	42C \| ANX2L \| ANX2LG \| CAL1L \| CLP11 \| Ca[1] \| GP11 \| MGC111133 \| P11 \| p10	S100 calcium binding protein A10	-	HPRD	2148288 \|8898866 \|12660155
S100A10	42C \| ANX2L \| ANX2LG \| CAL1L \| CLP11 \| Ca[1] \| GP11 \| MGC111133 \| P11 \| p10	S100 calcium binding protein A10	Co-crystal Structure	BioGRID	9886297
S100A4	18A2 \| 42A \| CAPL \| FSP1 \| MTS1 \| P9KA \| PEL98	S100 calcium binding protein A4	-	HPRD	15788416
S100A6	2A9 \| 5B10 \| CABP \| CACY \| PRA	S100 calcium binding protein A6	-	HPRD	1999197
SOS1	GF1 \| GGF1 \| GINGF \| HGF \| NS4	son of sevenless homolog 1 (Drosophila)	Reconstituted Complex	BioGRID	7510700
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD,BioGRID	11106497
TRPV5	CAT2 \| ECAC1 \| OTRPC3	transient receptor potential cation channel, subfamily V, member 5	Reconstituted Complex	BioGRID	12660155

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
HOLLMANN APOPTOSIS VIA CD40 DN	267	178	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN	320	184	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED UP	112	71	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
GRABARCZYK BCL11B TARGETS UP	81	40	All SZGR 2.0 genes in this pathway
BARRIER COLON CANCER RECURRENCE UP	42	28	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP	185	126	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP	157	104	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP	44	30	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP	443	294	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP	239	157	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
BORLAK LIVER CANCER EGF UP	57	41	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM2	153	102	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A UP	142	104	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
LIAO METASTASIS	539	324	All SZGR 2.0 genes in this pathway
COLIN PILOCYTIC ASTROCYTOMA VS GLIOBLASTOMA DN	28	21	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA UP	61	40	All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING DN	90	57	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 UP	64	40	All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP	205	126	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 UP	56	34	All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO HD MTX UP	23	13	All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN	85	56	All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA	176	122	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA UP	60	40	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 UP	62	35	All SZGR 2.0 genes in this pathway
XU RESPONSE TO TRETINOIN DN	13	8	All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP	151	103	All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP	81	52	All SZGR 2.0 genes in this pathway
BRUNO HEMATOPOIESIS	66	48	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN	408	274	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR	544	307	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN	298	200	All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP	175	116	All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA DN	52	33	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR DN	101	70	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS DN	64	44	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP	244	151	All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN	98	67	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP	222	139	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP	487	303	All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP	198	132	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP	123	75	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G1	67	41	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND MACROPHAGE	77	50	All SZGR 2.0 genes in this pathway
LEIN MEDULLA MARKERS	81	48	All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G	171	96	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
JIANG TIP30 TARGETS UP	46	28	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN	252	155	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP	338	225	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP	418	282	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN	245	150	All SZGR 2.0 genes in this pathway
HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE DN	75	61	All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM LOW RISK DN	30	20	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
ZHAN VARIABLE EARLY DIFFERENTIATION GENES UP	15	9	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2	491	319	All SZGR 2.0 genes in this pathway
NGO MALIGNANT GLIOMA 1P LOH	17	13	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD2 DN	46	29	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13	172	107	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G28	20	11	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 2HR DN	49	33	All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS UP	127	78	All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP	307	182	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL	216	130	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT	567	365	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN	505	328	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN	315	215	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
SERVITJA ISLET HNF1A TARGETS UP	163	111	All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP	135	96	All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7	403	240	All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS UP	149	96	All SZGR 2.0 genes in this pathway
NABA ECM AFFILIATED	171	89	All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED	753	411	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	198	205	1A,m8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-185	173	179	m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-409-3p	197	203	m8	hsa-miR-409-3p	CGAAUGUUGCUCGGUGAACCCCU
miR-9	186	192	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ANXA2