Gene Page: ANXA2

Summary
GeneID  302
Symbol  ANXA2
Synonyms  ANX2|ANX2L4|CAL1H|LIP2|LPC2|LPC2D|P36|PAP-IV
Description  annexin A2
See related  HGNC:537|MIM:151740|Ensembl:ENSG00000182718|HPRD:01061|
Locus tag  -
Gene type  protein-coding
Map location  15q21-q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0983 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004859phospholipase inhibitor activityIEA-
GO:0004859phospholipase inhibitor activityTAS3013422 
GO:0005544calcium-dependent phospholipid bindingIEA-
GO:0005509calcium ion bindingIEA-
GO:0008092cytoskeletal protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001501skeletal system developmentTAS7961821 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005604basement membraneIEA-
GO:0005625soluble fractionTAS7961821 
GO:0005886plasma membraneTAS10809787 
GO:0042470melanosomeIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APOHB2G1 | BGapolipoprotein H (beta-2-glycoprotein I)-HPRD,BioGRID10809787 
CD99MIC2 | MIC2X | MIC2YCD99 moleculeCD99 interacts with ANXA2.BIND15388255 
CEACAM1BGP | BGP1 | BGPIcarcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)-HPRD,BioGRID14522961 
CTSBAPPS | CPSBcathepsin B-HPRD,BioGRID10777578 
DYSFFER1L1 | FLJ00175 | FLJ90168 | LGMD2Bdysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)-HPRD14506282 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID7510700 
LGALS13GAL13 | PLAC8 | PP13lectin, galactoside-binding, soluble, 13-HPRD15009185 
LYPLA1APT-1 | LPL1 | LYSOPLAlysophospholipase I-HPRD,BioGRID1531641 
PCNAMGC8367proliferating cell nuclear antigen-HPRD,BioGRID9228079 |12171929 
PHBPHB1prohibitin-HPRD,BioGRID12628297 
PLA1APS-PLA1 | PSPLA1phospholipase A1 member A-HPRD,BioGRID1531641 
PLATDKFZp686I03148 | T-PA | TPAplasminogen activator, tissue-HPRD,BioGRID11978811 |12468550 
PLGDKFZp779M0222plasminogen-HPRD10077593 
PPM1BMGC21657 | PP2C-beta-X | PP2CB | PP2CBETA | PPC2BETAXprotein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoformAffinity Capture-MSBioGRID17353931 
S100A1042C | ANX2L | ANX2LG | CAL1L | CLP11 | Ca[1] | GP11 | MGC111133 | P11 | p10S100 calcium binding protein A10-HPRD2148288 |8898866 
|12660155 
Co-crystal StructureBioGRID9886297 
S100A418A2 | 42A | CAPL | FSP1 | MTS1 | P9KA | PEL98S100 calcium binding protein A4-HPRD15788416 
S100A62A9 | 5B10 | CABP | CACY | PRAS100 calcium binding protein A6-HPRD1999197 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)Reconstituted ComplexBioGRID7510700 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID11106497 
TRPV5CAT2 | ECAC1 | OTRPC3transient receptor potential cation channel, subfamily V, member 5Reconstituted ComplexBioGRID12660155 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
LAIHO_COLORECTAL_CANCER_SERRATED_UP 11271All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
GRABARCZYK_BCL11B_TARGETS_UP 8140All SZGR genes in this pathway
BARRIER_COLON_CANCER_RECURRENCE_UP 4228All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP 185126All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP 157104All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINDED_IN_ERYTHROCYTE_UP 4430All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
BORLAK_LIVER_CANCER_EGF_UP 5741All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2 153102All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP 142104All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_DN 2821All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_TGFA_UP 6140All SZGR genes in this pathway
SANA_TNF_SIGNALING_DN 9057All SZGR genes in this pathway
LEE_LIVER_CANCER_ACOX1_UP 6440All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_UP 205126All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_E2F1_UP 5634All SZGR genes in this pathway
CHEOK_RESPONSE_TO_HD_MTX_UP 2313All SZGR genes in this pathway
SANA_RESPONSE_TO_IFNG_DN 8556All SZGR genes in this pathway
SASAKI_ADULT_T_CELL_LEUKEMIA 176122All SZGR genes in this pathway
LEE_LIVER_CANCER_DENA_UP 6040All SZGR genes in this pathway
LEE_LIVER_CANCER_E2F1_UP 6235All SZGR genes in this pathway
XU_RESPONSE_TO_TRETINOIN_DN 138All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
MUNSHI_MULTIPLE_MYELOMA_UP 8152All SZGR genes in this pathway
BRUNO_HEMATOPOIESIS 6648All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_UP 175116All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_DN 5233All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_DN 10170All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
GERHOLD_ADIPOGENESIS_DN 6444All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_DN 9867All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_UP 222139All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_UP 12375All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G1 6741All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_MACROPHAGE 7750All SZGR genes in this pathway
LEIN_MEDULLA_MARKERS 8148All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_2G 17196All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
JIANG_TIP30_TARGETS_UP 4628All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN 245150All SZGR genes in this pathway
HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_DN 7561All SZGR genes in this pathway
HOFMANN_MYELODYSPLASTIC_SYNDROM_LOW_RISK_DN 3020All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
ZHAN_VARIABLE_EARLY_DIFFERENTIATION_GENES_UP 159All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
NGO_MALIGNANT_GLIOMA_1P_LOH 1713All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD2_DN 4629All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13 172107All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G28 2011All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_2HR_DN 4933All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_UP 12778All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_UP 307182All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP 163111All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_UP 13596All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
HUANG_GATA2_TARGETS_UP 14996All SZGR genes in this pathway
NABA_ECM_AFFILIATED 17189All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2061982051A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-185173179m8hsa-miR-185brainUGGAGAGAAAGGCAGUUC
miR-409-3p197203m8hsa-miR-409-3pCGAAUGUUGCUCGGUGAACCCCU
miR-91861921Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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