Gene Page: HLA-DRB3
Summary ?
GeneID | 3125 |
Symbol | HLA-DRB3 |
Synonyms | DRB1|DRw10|HLA-DR1B|HLA-DR3B|HLA-DRB|SS1 |
Description | major histocompatibility complex, class II, DR beta 3 |
Reference | MIM:612735|HGNC:HGNC:4951|HPRD:09985| |
Gene type | protein-coding |
Map location | 6p21.3 |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0032395 | MHC class II receptor activity | NAS | 6414998 | |
GO:0032395 | MHC class II receptor activity | TAS | 11144299 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | IEA | - | |
GO:0007165 | signal transduction | NAS | 8775462 | |
GO:0006955 | immune response | IEA | - | |
GO:0006955 | immune response | TAS | 10609818 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0016020 | membrane | IEA | - | |
GO:0016020 | membrane | TAS | 11144299 | |
GO:0016021 | integral to membrane | IEA | - | |
GO:0005886 | plasma membrane | EXP | 11048639 |11827988 |15489916 |17652306 | |
GO:0005887 | integral to plasma membrane | NAS | 6414998 | |
GO:0042613 | MHC class II protein complex | IEA | - |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG CELL ADHESION MOLECULES CAMS | 134 | 93 | All SZGR 2.0 genes in this pathway |
KEGG ANTIGEN PROCESSING AND PRESENTATION | 89 | 65 | All SZGR 2.0 genes in this pathway |
KEGG HEMATOPOIETIC CELL LINEAGE | 88 | 60 | All SZGR 2.0 genes in this pathway |
KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION | 48 | 36 | All SZGR 2.0 genes in this pathway |
KEGG TYPE I DIABETES MELLITUS | 44 | 38 | All SZGR 2.0 genes in this pathway |
KEGG LEISHMANIA INFECTION | 72 | 56 | All SZGR 2.0 genes in this pathway |
KEGG ASTHMA | 30 | 25 | All SZGR 2.0 genes in this pathway |
KEGG AUTOIMMUNE THYROID DISEASE | 53 | 49 | All SZGR 2.0 genes in this pathway |
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS | 140 | 100 | All SZGR 2.0 genes in this pathway |
KEGG ALLOGRAFT REJECTION | 38 | 34 | All SZGR 2.0 genes in this pathway |
KEGG GRAFT VERSUS HOST DISEASE | 42 | 31 | All SZGR 2.0 genes in this pathway |
KEGG VIRAL MYOCARDITIS | 73 | 58 | All SZGR 2.0 genes in this pathway |
REACTOME MHC CLASS II ANTIGEN PRESENTATION | 91 | 61 | All SZGR 2.0 genes in this pathway |
REACTOME TCR SIGNALING | 54 | 46 | All SZGR 2.0 genes in this pathway |
REACTOME DOWNSTREAM TCR SIGNALING | 37 | 32 | All SZGR 2.0 genes in this pathway |
REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | 16 | 15 | All SZGR 2.0 genes in this pathway |
REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | 14 | 14 | All SZGR 2.0 genes in this pathway |
REACTOME GENERATION OF SECOND MESSENGER MOLECULES | 27 | 25 | All SZGR 2.0 genes in this pathway |
REACTOME PD1 SIGNALING | 18 | 14 | All SZGR 2.0 genes in this pathway |
REACTOME COSTIMULATION BY THE CD28 FAMILY | 63 | 48 | All SZGR 2.0 genes in this pathway |
REACTOME INTERFERON GAMMA SIGNALING | 63 | 48 | All SZGR 2.0 genes in this pathway |
REACTOME INTERFERON SIGNALING | 159 | 116 | All SZGR 2.0 genes in this pathway |
REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
REACTOME ADAPTIVE IMMUNE SYSTEM | 539 | 350 | All SZGR 2.0 genes in this pathway |
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM | 270 | 204 | All SZGR 2.0 genes in this pathway |
HAMAI APOPTOSIS VIA TRAIL DN | 186 | 107 | All SZGR 2.0 genes in this pathway |
CAVARD LIVER CANCER MALIGNANT VS BENIGN | 32 | 19 | All SZGR 2.0 genes in this pathway |
TSUNODA CISPLATIN RESISTANCE DN | 51 | 38 | All SZGR 2.0 genes in this pathway |
GOERING BLOOD HDL CHOLESTEROL QTL CIS | 13 | 7 | All SZGR 2.0 genes in this pathway |
SANA RESPONSE TO IFNG UP | 78 | 50 | All SZGR 2.0 genes in this pathway |
HENDRICKS SMARCA4 TARGETS DN | 53 | 34 | All SZGR 2.0 genes in this pathway |
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP | 174 | 96 | All SZGR 2.0 genes in this pathway |
GAURNIER PSMD4 TARGETS | 73 | 55 | All SZGR 2.0 genes in this pathway |
LINDSTEDT DENDRITIC CELL MATURATION C | 69 | 49 | All SZGR 2.0 genes in this pathway |
DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |