Gene Page: HMOX2
Summary ?
| GeneID | 3163 |
| Symbol | HMOX2 |
| Synonyms | HO-2 |
| Description | heme oxygenase 2 |
| Reference | MIM:141251|HGNC:HGNC:5014|Ensembl:ENSG00000103415|HPRD:00783|Vega:OTTHUMG00000129473 |
| Gene type | protein-coding |
| Map location | 16p13.3 |
| Pascal p-value | 3.504E-6 |
| eGene | Cerebellum Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg14951292 | 16 | 4525986 | HMOX2;NMRAL1 | 8.39E-5 | 0.484 | 0.026 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs1940245 | chr9 | 113522916 | HMOX2 | 3163 | 0.2 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NPM1 | 0.95 | 0.93 |
| RBMX | 0.95 | 0.94 |
| DCAF13 | 0.94 | 0.91 |
| CPSF3 | 0.94 | 0.91 |
| RBBP4 | 0.94 | 0.92 |
| CCT2 | 0.94 | 0.94 |
| UBA2 | 0.94 | 0.89 |
| XRCC6 | 0.94 | 0.93 |
| MKI67IP | 0.94 | 0.93 |
| PRIM2 | 0.94 | 0.90 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.66 | -0.83 |
| AF347015.33 | -0.66 | -0.83 |
| HLA-F | -0.65 | -0.78 |
| MT-CYB | -0.65 | -0.83 |
| AF347015.27 | -0.65 | -0.80 |
| AF347015.8 | -0.64 | -0.82 |
| AF347015.31 | -0.64 | -0.79 |
| AIFM3 | -0.63 | -0.76 |
| TINAGL1 | -0.63 | -0.76 |
| AF347015.15 | -0.62 | -0.82 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| APP | AAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2 | amyloid beta (A4) precursor protein | - | HPRD | 12057765 |
| C1orf103 | FLJ11269 | RIF1 | RP11-96K19.1 | chromosome 1 open reading frame 103 | Two-hybrid | BioGRID | 16169070 |
| COPS6 | CSN6 | MOV34-34KD | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) | Two-hybrid | BioGRID | 16169070 |
| EEF1G | EF1G | GIG35 | eukaryotic translation elongation factor 1 gamma | Two-hybrid | BioGRID | 16169070 |
| GIT1 | - | G protein-coupled receptor kinase interacting ArfGAP 1 | Two-hybrid | BioGRID | 16169070 |
| GPRASP1 | GASP | GASP1 | KIAA0443 | G protein-coupled receptor associated sorting protein 1 | Two-hybrid | BioGRID | 16169070 |
| HAP1 | HAP2 | HIP5 | HLP | hHLP1 | huntingtin-associated protein 1 | Two-hybrid | BioGRID | 16169070 |
| KCNMA1 | BKTM | DKFZp686K1437 | KCa1.1 | MGC71881 | MaxiK | SAKCA | SLO | SLO-ALPHA | SLO1 | mSLO1 | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | - | HPRD | 15528406 |
| KCNMA1 | BKTM | DKFZp686K1437 | KCa1.1 | MGC71881 | MaxiK | SAKCA | SLO | SLO-ALPHA | SLO1 | mSLO1 | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | KCNMA1 interacts with HO-2. | BIND | 15528406 |
| KIAA1377 | - | KIAA1377 | Two-hybrid | BioGRID | 16169070 |
| MED31 | 3110004H13Rik | CGI-125 | FLJ27436 | FLJ36714 | Soh1 | mediator complex subunit 31 | Two-hybrid | BioGRID | 16169070 |
| SETDB1 | ESET | KG1T | KIAA0067 | KMT1E | SET domain, bifurcated 1 | Two-hybrid | BioGRID | 16169070 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PORPHYRIN AND CHLOROPHYLL METABOLISM | 41 | 23 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 413 | 270 | All SZGR 2.0 genes in this pathway |
| REACTOME IRON UPTAKE AND TRANSPORT | 36 | 18 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF PORPHYRINS | 14 | 7 | All SZGR 2.0 genes in this pathway |
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP | 579 | 346 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | 637 | 377 | All SZGR 2.0 genes in this pathway |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN | 382 | 224 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| HOUSTIS ROS | 36 | 29 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS | 185 | 114 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR | 681 | 420 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS DN | 314 | 188 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | All SZGR 2.0 genes in this pathway |
| GAVIN PDE3B TARGETS | 22 | 15 | All SZGR 2.0 genes in this pathway |
| STEIN ESRRA TARGETS UP | 388 | 234 | All SZGR 2.0 genes in this pathway |
| WINTER HYPOXIA METAGENE | 242 | 168 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| BOYAULT LIVER CANCER SUBCLASS G1 DN | 40 | 26 | All SZGR 2.0 genes in this pathway |
| STEIN ESRRA TARGETS | 535 | 325 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER SUBCLASS S3 | 266 | 180 | All SZGR 2.0 genes in this pathway |
| LI DCP2 BOUND MRNA | 89 | 57 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |