SZGR2

Summary ?

GeneID	3183
Symbol	HNRNPC
Synonyms	C1\|C2\|HNRNP\|HNRPC\|SNRPC
Description	heterogeneous nuclear ribonucleoprotein C (C1/C2)
Reference	MIM:164020\|HGNC:HGNC:5035\|Ensembl:ENSG00000092199\|HPRD:01243\|Vega:OTTHUMG00000170757
Gene type	protein-coding
Map location	14q11.2
Pascal p-value	0.244
Sherlock p-value	0.014
Fetal beta	0.485
Support	Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
GSMA_I	Genome scan meta-analysis	Psr: 0.047

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0003723	RNA binding	NAS		9731529
GO:0042802	identical protein binding	IPI		16189514
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000398	nuclear mRNA splicing, via spliceosome	EXP		12226669
GO:0000398	nuclear mRNA splicing, via spliceosome	IC		9731529
GO:0008380	RNA splicing	TAS		3110598
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IEA		-
GO:0005681	spliceosome	IDA		9731529

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AP1M1	AP47 \| CLAPM2 \| CLTNM \| MU-1A	adaptor-related protein complex 1, mu 1 subunit	Two-hybrid	BioGRID	16189514
CCDC85B	DIPA	coiled-coil domain containing 85B	Two-hybrid	BioGRID	16189514
CNBP	CNBP1 \| DM2 \| FLJ11631 \| PROMM \| RNF163 \| ZCCHC22 \| ZNF9	CCHC-type zinc finger, nucleic acid binding protein	Affinity Capture-MS	BioGRID	17353931
FXR2	FMR1L2	fragile X mental retardation, autosomal homolog 2	Two-hybrid	BioGRID	16189514
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	9516488
HNRNPC	C1 \| C2 \| HNRNP \| HNRPC \| MGC104306 \| MGC105117 \| MGC117353 \| MGC131677 \| SNRPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10772858 \|16189514
KPNA3	IPOA4 \| SRP1gamma \| SRP4 \| hSRP1	karyopherin alpha 3 (importin alpha 4)	Two-hybrid	BioGRID	16189514
KRAS	C-K-RAS \| K-RAS2A \| K-RAS2B \| K-RAS4A \| K-RAS4B \| KI-RAS \| KRAS1 \| KRAS2 \| NS3 \| RASK2	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	Two-hybrid	BioGRID	16189514
LMO3	DAT1 \| MGC26081 \| RBTN3 \| RBTNL2 \| RHOM3 \| Rhom-3	LIM domain only 3 (rhombotin-like 2)	Two-hybrid	BioGRID	16189514
MYC	bHLHe39 \| c-Myc	v-myc myelocytomatosis viral oncogene homolog (avian)	Affinity Capture-MS	BioGRID	17353931
PDGFB	FLJ12858 \| PDGF2 \| SIS \| SSV \| c-sis	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	-	HPRD	10409733
PHKB	DKFZp781E15103 \| FLJ41698	phosphorylase kinase, beta	Two-hybrid	BioGRID	16189514
PIN1	DOD \| UBL5	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Two-hybrid	BioGRID	16189514
PUF60	FIR \| FLJ31379 \| RoBPI \| SIAHBP1	poly-U binding splicing factor 60KDa	Affinity Capture-MS	BioGRID	17353931
RALYL	HNRPCL3	RALY RNA binding protein-like	Two-hybrid	BioGRID	16189514
RBM41	FLJ11016 \| FLJ13670 \| bB383K5.1	RNA binding motif protein 41	Two-hybrid	BioGRID	16189514
SFRS12	DKFZp564B176 \| MGC133045 \| SRrp508 \| SRrp86	splicing factor, arginine/serine-rich 12	-	HPRD	14559993
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	Two-hybrid	BioGRID	16189514
ZNF581	FLJ22550 \| HSPC189	zinc finger protein 581	Two-hybrid	BioGRID	16189514

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG SPLICEOSOME	128	72	All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY	68	48	All SZGR 2.0 genes in this pathway
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	140	77	All SZGR 2.0 genes in this pathway
REACTOME MRNA PROCESSING	161	86	All SZGR 2.0 genes in this pathway
REACTOME MRNA SPLICING	111	58	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN	431	263	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED UP	112	71	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN	406	230	All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN	362	238	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN	459	276	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX4 DN	32	22	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN	309	206	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND UP	77	52	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO CANTHARIDIN DN	69	46	All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL	311	205	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY 4NQO IN WS	40	26	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP	226	164	All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE DN	21	12	All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP	125	89	All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP	578	341	All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN	92	64	All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2	118	65	All SZGR 2.0 genes in this pathway
GRADE COLON VS RECTAL CANCER UP	38	21	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN	175	103	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
YOSHIOKA LIVER CANCER EARLY RECURRENCE UP	40	23	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2	115	74	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 7	76	46	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES	275	155	All SZGR 2.0 genes in this pathway
KUMAR AUTOPHAGY NETWORK	71	46	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-208	553	559	1A	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-224	254	260	1A	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-299-5p	650	656	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-320	411	417	m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-455	1	7	1A	hsa-miR-455	UAUGUGCCUUUGGACUACAUCG
miR-499	552	559	1A,m8	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: HNRNPC