Gene Page: HOXD1
Summary ?
| GeneID | 3231 |
| Symbol | HOXD1 |
| Synonyms | HOX4|HOX4G|Hox-4.7 |
| Description | homeobox D1 |
| Reference | MIM:142987|HGNC:HGNC:5132|Ensembl:ENSG00000128645|HPRD:00870|Vega:OTTHUMG00000132512 |
| Gene type | protein-coding |
| Map location | 2q31.1 |
| Pascal p-value | 0.033 |
| eGene | Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MDH1 | 0.92 | 0.93 |
| GHITM | 0.91 | 0.92 |
| SERPINI1 | 0.91 | 0.90 |
| ATP6V1E1 | 0.91 | 0.92 |
| CHN1 | 0.91 | 0.83 |
| GOT1 | 0.90 | 0.93 |
| GABARAPL3 | 0.90 | 0.92 |
| NAPB | 0.89 | 0.90 |
| GLRB | 0.89 | 0.88 |
| CCNDBP1 | 0.89 | 0.90 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SMTN | -0.51 | -0.52 |
| SH3BP2 | -0.50 | -0.53 |
| FADS2 | -0.50 | -0.41 |
| SEMA4B | -0.49 | -0.43 |
| SH2D2A | -0.49 | -0.49 |
| NME4 | -0.48 | -0.56 |
| FAM59B | -0.48 | -0.45 |
| CDC42EP4 | -0.47 | -0.44 |
| HYAL2 | -0.47 | -0.46 |
| BCL7C | -0.47 | -0.51 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ODONNELL METASTASIS UP | 82 | 58 | All SZGR 2.0 genes in this pathway |
| MARTORIATI MDM4 TARGETS FETAL LIVER UP | 227 | 137 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | All SZGR 2.0 genes in this pathway |
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| BENPORATH PRC2 TARGETS | 652 | 441 | All SZGR 2.0 genes in this pathway |
| SHIN B CELL LYMPHOMA CLUSTER 5 | 18 | 11 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING | 246 | 152 | All SZGR 2.0 genes in this pathway |
| MCGARVEY SILENCED BY METHYLATION IN COLON CANCER | 42 | 29 | All SZGR 2.0 genes in this pathway |
| SWEET LUNG CANCER KRAS UP | 491 | 316 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K27ME3 | 269 | 159 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 | 349 | 234 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 | 210 | 148 | All SZGR 2.0 genes in this pathway |
| ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN | 116 | 74 | All SZGR 2.0 genes in this pathway |