Gene Page: APEH
Summary ?
| GeneID | 327 |
| Symbol | APEH |
| Synonyms | AARE|ACPH|APH|D3F15S2|D3S48E|DNF15S2|OPH |
| Description | acylaminoacyl-peptide hydrolase |
| Reference | MIM:102645|HGNC:HGNC:586|Ensembl:ENSG00000164062|HPRD:00034|Vega:OTTHUMG00000156882 |
| Gene type | protein-coding |
| Map location | 3p21.31 |
| Pascal p-value | 0.041 |
| Sherlock p-value | 0.988 |
| Fetal beta | -0.594 |
| DMG | 1 (# studies) |
| eGene | Cortex |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg00904548 | 3 | 49720819 | APEH | 2.488E-4 | 0.469 | 0.037 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AK5 | 0.74 | 0.82 |
| HPCAL4 | 0.73 | 0.73 |
| RNF128 | 0.72 | 0.78 |
| ARL1 | 0.71 | 0.75 |
| ATP6V1C1 | 0.71 | 0.74 |
| DGKG | 0.71 | 0.70 |
| IDH3A | 0.71 | 0.74 |
| MAP2K1 | 0.71 | 0.74 |
| FAM69A | 0.71 | 0.73 |
| CAPS2 | 0.70 | 0.70 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SH2B2 | -0.45 | -0.52 |
| SH3BP2 | -0.43 | -0.49 |
| CARHSP1 | -0.43 | -0.50 |
| SH2D2A | -0.43 | -0.49 |
| EIF4EBP1 | -0.43 | -0.50 |
| TRAF4 | -0.43 | -0.51 |
| RPL28 | -0.43 | -0.54 |
| IGFBP2 | -0.43 | -0.42 |
| BCL7C | -0.42 | -0.54 |
| KIAA1949 | -0.42 | -0.40 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004252 | serine-type endopeptidase activity | TAS | glutamate (GO term level: 7) | 2006156 |
| GO:0016787 | hydrolase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006508 | proteolysis | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005737 | cytoplasm | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GAZDA DIAMOND BLACKFAN ANEMIA PROGENITOR DN | 66 | 42 | All SZGR 2.0 genes in this pathway |
| GARY CD5 TARGETS UP | 473 | 314 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| UDAYAKUMAR MED1 TARGETS UP | 135 | 82 | All SZGR 2.0 genes in this pathway |
| KIM WT1 TARGETS DN | 459 | 276 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE EPIDERMIS UP | 293 | 179 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS UP | 566 | 371 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE DN | 841 | 431 | All SZGR 2.0 genes in this pathway |
| LI DCP2 BOUND MRNA | 89 | 57 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |