SZGR2

Summary ?

GeneID	3309
Symbol	HSPA5
Synonyms	BIP\|GRP78\|HEL-S-89n\|MIF2
Description	heat shock protein family A (Hsp70) member 5
Reference	MIM:138120\|HGNC:HGNC:5238\|Ensembl:ENSG00000044574\|HPRD:00682\|Vega:OTTHUMG00000020672
Gene type	protein-coding
Map location	9q33.3
Pascal p-value	0.549
Sherlock p-value	0.053
Fetal beta	0.241
eGene	Myers' cis & trans
Support	RNA AND PROTEIN SYNTHESIS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_clathrin G2Cdb.human_Synaptosome G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.7656

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs10868543	chr9	89852686	HSPA5	3309		0.16		trans
rs7331934	chr13	29698636	HSPA5	3309		0.15		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
XRCC6	0.89	0.89
DDX50	0.89	0.90
DNAJA1	0.88	0.88
CPSF3	0.88	0.90
CCT5	0.88	0.90
ME2	0.88	0.88
ST13	0.88	0.87
TARS	0.88	0.89
C22orf28	0.87	0.86
CCT6A	0.87	0.92

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MT-CO2	-0.68	-0.76
AF347015.31	-0.68	-0.76
IFI27	-0.68	-0.76
AF347015.33	-0.67	-0.77
AF347015.21	-0.67	-0.74
AF347015.27	-0.66	-0.74
AF347015.8	-0.66	-0.75
FXYD1	-0.65	-0.74
HIGD1B	-0.65	-0.74
MT-CYB	-0.64	-0.73

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0005509	calcium ion binding	TAS		16130169
GO:0005524	ATP binding	NAS		12665508
GO:0030674	protein binding, bridging	NAS		-
GO:0051082	unfolded protein binding	TAS		16130169
GO:0043022	ribosome binding	IEA		-
GO:0043027	caspase inhibitor activity	IDA		12665508
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006983	ER overload response	IEA		-
GO:0006916	anti-apoptosis	IMP		12665508
GO:0006916	anti-apoptosis	TAS		16130169
GO:0042149	cellular response to glucose starvation	IDA		10085239
GO:0043154	negative regulation of caspase activity	IDA		12665508
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005793	ER-Golgi intermediate compartment	IDA		15308636
GO:0005788	endoplasmic reticulum lumen	TAS		12665508
GO:0005634	nucleus	IDA		12665508
GO:0005783	endoplasmic reticulum	TAS		16130169
GO:0009986	cell surface	IDA		12493773
GO:0008303	caspase complex	IDA		12665508
GO:0048471	perinuclear region of cytoplasm	IDA		12665508
GO:0030176	integral to endoplasmic reticulum membrane	IDA		12665508
GO:0042470	melanosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
A2M	CPAMD5 \| DKFZp779B086 \| FWP007 \| S863-7	alpha-2-macroglobulin	-	HPRD,BioGRID	12194978
APOB	FLDB	apolipoprotein B (including Ag(x) antigen)	-	HPRD	12397072
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	Two-hybrid	BioGRID	16169070
CASP12	CASP12P1	caspase 12 (gene/pseudogene)	Affinity Capture-Western	BioGRID	11943137
CASP7	CMH-1 \| ICE-LAP3 \| MCH3	caspase 7, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	11943137
DDX24	-	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	Two-hybrid	BioGRID	16169070
DNAJC1	DNAJL1 \| ERdj1 \| HTJ1 \| MGC131954 \| MTJ1	DnaJ (Hsp40) homolog, subfamily C, member 1	-	HPRD	10777498
DNAJC10	DKFZp434J1813 \| ERdj5 \| JPDI \| MGC104194	DnaJ (Hsp40) homolog, subfamily C, member 10	-	HPRD,BioGRID	12411443
DPH1	DPH2L \| DPH2L1 \| FLJ33211 \| OVCA1	DPH1 homolog (S. cerevisiae)	-	HPRD,BioGRID	11013075
EIF2AK3	DKFZp781H1925 \| HRI \| PEK \| PERK \| WRS	eukaryotic translation initiation factor 2-alpha kinase 3	-	HPRD,BioGRID	11907036
ERN1	FLJ30999 \| IRE1 \| IRE1P \| MGC163277 \| MGC163279	endoplasmic reticulum to nucleus signaling 1	-	HPRD,BioGRID	12637535
ERP29	C12orf8 \| ERp28 \| ERp31 \| PDI-DB	endoplasmic reticulum protein 29	-	HPRD	9492298
F8	AHF \| DXS1253E \| F8B \| F8C \| FVIII \| HEMA	coagulation factor VIII, procoagulant component	-	HPRD	9305856
GRIA1	GLUH1 \| GLUR1 \| GLURA \| HBGR1 \| MGC133252	glutamate receptor, ionotropic, AMPA 1	-	HPRD	10461883
HLA-C	D6S204 \| FLJ27082 \| HLA-Cw \| HLA-Cw12 \| HLA-JY3 \| HLC-C \| PSORS1	major histocompatibility complex, class I, C	-	HPRD,BioGRID	7957306
HTR3A	5-HT-3 \| 5-HT3A \| 5-HT3R \| 5HT3R \| HTR3	5-hydroxytryptamine (serotonin) receptor 3A	-	HPRD	12359150
IGHM	DKFZp686I15196 \| DKFZp686I15212 \| FLJ00385 \| MGC104996 \| MGC52291 \| MU \| VH	immunoglobulin heavy constant mu	-	HPRD	3122216
KRT18	CYK18 \| K18	keratin 18	-	HPRD	9409741
KRT8	CARD2 \| CK8 \| CYK8 \| K2C8 \| K8 \| KO	keratin 8	-	HPRD,BioGRID	9409741
LCT	LAC \| LPH \| LPH1	lactase	-	HPRD,BioGRID	11751874
LDLR	FH \| FHC	low density lipoprotein receptor	-	HPRD,BioGRID	10906332
MAP3K7	TAK1 \| TGF1a	mitogen-activated protein kinase kinase kinase 7	-	HPRD	14743216
MAP3K7IP2	FLJ21885 \| KIAA0733 \| TAB2	mitogen-activated protein kinase kinase kinase 7 interacting protein 2	-	HPRD	14743216
PCSK7	LPC \| PC7 \| PC8 \| SPC7	proprotein convertase subtilisin/kexin type 7	-	HPRD,BioGRID	10964928
PRNP	ASCR \| CD230 \| CJD \| GSS \| MGC26679 \| PRIP \| PrP \| PrP27-30 \| PrP33-35C \| PrPc \| prion	prion protein	PrPc interacts with HSPA5 (BiP).	BIND	10970892
PSME3	Ki \| PA28-gamma \| PA28G \| REG-GAMMA	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)	Two-hybrid	BioGRID	16169070
SIL1	BAP \| MSS \| ULG5	SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)	-	HPRD,BioGRID	12356756
STMN1	LAP18 \| Lag \| OP18 \| PP17 \| PP19 \| PR22 \| SMN	stathmin 1/oncoprotein 18	-	HPRD,BioGRID	7724523 \|10197448
TCERG1	CA150 \| MGC133200 \| TAF2S	transcription elongation regulator 1	-	HPRD,BioGRID	15456888
TG	AITD3 \| TGN	thyroglobulin	-	HPRD,BioGRID	10049727 \|11294872
TMEM132A	DKFZp547E212 \| FLJ20539 \| GBP \| HSPA5BP1 \| MGC138669	transmembrane protein 132A	-	HPRD,BioGRID	12514190
TRA@	FLJ22602 \| MGC117436 \| MGC22624 \| MGC23964 \| MGC71411 \| TCRA \| TCRD \| TRA	T cell receptor alpha locus	-	HPRD	1649196
TSHR	CHNG1 \| LGR3 \| MGC75129 \| hTSHR-I	thyroid stimulating hormone receptor	TSHR interacts with BiP. This interaction was modeled on a demonstrated interaction between human TSHR and hamster BiP.	BIND	12383251
TSHR	CHNG1 \| LGR3 \| MGC75129 \| hTSHR-I	thyroid stimulating hormone receptor	-	HPRD,BioGRID	12383251
VWF	F8VWF \| VWD	von Willebrand factor	-	HPRD,BioGRID	10887119

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG PROTEIN EXPORT	24	16	All SZGR 2.0 genes in this pathway
KEGG ANTIGEN PROCESSING AND PRESENTATION	89	65	All SZGR 2.0 genes in this pathway
KEGG PRION DISEASES	35	28	All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	89	56	All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS	133	91	All SZGR 2.0 genes in this pathway
REACTOME PERK REGULATED GENE EXPRESSION	29	14	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	13	9	All SZGR 2.0 genes in this pathway
REACTOME UNFOLDED PROTEIN RESPONSE	80	51	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	11	8	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	21	17	All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	251	156	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN	634	384	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN	463	290	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN	431	263	All SZGR 2.0 genes in this pathway
NOJIMA SFRP2 TARGETS UP	31	23	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP	204	140	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR DN	214	133	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN	459	276	All SZGR 2.0 genes in this pathway
BERENJENO ROCK SIGNALING NOT VIA RHOA DN	48	34	All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP	88	58	All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER	178	108	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
NEBEN AML WITH FLT3 OR NRAS DN	12	6	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN	156	106	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
DEN INTERACT WITH LCA5	26	21	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN	81	51	All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME DN	17	9	All SZGR 2.0 genes in this pathway
GOTTWEIN TARGETS OF KSHV MIR K12 11	63	45	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE UP	78	51	All SZGR 2.0 genes in this pathway
ROSS AML WITH PML RARA FUSION	77	62	All SZGR 2.0 genes in this pathway
UEDA CENTRAL CLOCK	88	62	All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP	145	91	All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN	187	122	All SZGR 2.0 genes in this pathway
CHEN LUNG CANCER SURVIVAL	28	22	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC DN	63	40	All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN	245	154	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
ADDYA ERYTHROID DIFFERENTIATION BY HEMIN	73	47	All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR UP	78	56	All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP	81	52	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
MCCLUNG COCAINE REWARD 5D	79	62	All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP	175	116	All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP	198	132	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN	165	106	All SZGR 2.0 genes in this pathway
RAMPON ENRICHED LEARNING ENVIRONMENT EARLY UP	15	12	All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL	311	205	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP	202	115	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C7	68	44	All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE DN	49	34	All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP	64	40	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN	292	189	All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP	578	341	All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN	354	216	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN	540	340	All SZGR 2.0 genes in this pathway
HONMA DOCETAXEL RESISTANCE	34	23	All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP	125	68	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP	491	316	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN	457	302	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN	668	419	All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS DN	17	14	All SZGR 2.0 genes in this pathway
NGO MALIGNANT GLIOMA 1P LOH	17	13	All SZGR 2.0 genes in this pathway
WINNEPENNINCKX MELANOMA METASTASIS UP	162	86	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 11	103	68	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
WIERENGA PML INTERACTOME	42	23	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38	337	236	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-181	84	90	1A	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-199	345	351	m8	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	345	351	m8	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-30-5p	142	148	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-378	41	47	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-379	309	315	1A	hsa-miR-379^brain	UGGUAGACUAUGGAACGUA
miR-495	334	341	1A,m8	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: HSPA5