Gene Page: HSPA5

Summary
GeneID  3309
Symbol  HSPA5
Synonyms  BIP|FLJ26106|GRP78|MIF2
Description  heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
See related  HGNC:5238|MIM:138120|Ensembl:ENSG00000044574|HPRD:00682|
Locus tag  -
Gene type  protein-coding
Map location  9q33-q34.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.7656 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
XRCC60.890.89
DDX500.890.90
DNAJA10.880.88
CPSF30.880.90
CCT50.880.90
ME20.880.88
ST130.880.87
TARS0.880.89
C22orf280.870.86
CCT6A0.870.92
Top 10 negatively co-expressed genes
MT-CO2-0.68-0.76
AF347015.31-0.68-0.76
IFI27-0.68-0.76
AF347015.33-0.67-0.77
AF347015.21-0.67-0.74
AF347015.27-0.66-0.74
AF347015.8-0.66-0.75
FXYD1-0.65-0.74
HIGD1B-0.65-0.74
MT-CYB-0.64-0.73
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005509calcium ion bindingTAS16130169 
GO:0005524ATP bindingNAS12665508 
GO:0030674protein binding, bridgingNAS-
GO:0051082unfolded protein bindingTAS16130169 
GO:0043022ribosome bindingIEA-
GO:0043027caspase inhibitor activityIDA12665508 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006983ER overload responseIEA-
GO:0006916anti-apoptosisIMP12665508 
GO:0006916anti-apoptosisTAS16130169 
GO:0042149cellular response to glucose starvationIDA10085239 
GO:0043154negative regulation of caspase activityIDA12665508 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005793ER-Golgi intermediate compartmentIDA15308636 
GO:0005788endoplasmic reticulum lumenTAS12665508 
GO:0005634nucleusIDA12665508 
GO:0005783endoplasmic reticulumTAS16130169 
GO:0009986cell surfaceIDA12493773 
GO:0008303caspase complexIDA12665508 
GO:0048471perinuclear region of cytoplasmIDA12665508 
GO:0030176integral to endoplasmic reticulum membraneIDA12665508 
GO:0042470melanosomeIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
A2MCPAMD5 | DKFZp779B086 | FWP007 | S863-7alpha-2-macroglobulin-HPRD,BioGRID12194978 
APOBFLDBapolipoprotein B (including Ag(x) antigen)-HPRD12397072 
BCAR1CAS | CAS1 | CASS1 | CRKAS | P130Casbreast cancer anti-estrogen resistance 1Two-hybridBioGRID16169070 
CASP12CASP12P1caspase 12 (gene/pseudogene)Affinity Capture-WesternBioGRID11943137 
CASP7CMH-1 | ICE-LAP3 | MCH3caspase 7, apoptosis-related cysteine peptidase-HPRD,BioGRID11943137 
DDX24-DEAD (Asp-Glu-Ala-Asp) box polypeptide 24Two-hybridBioGRID16169070 
DNAJC1DNAJL1 | ERdj1 | HTJ1 | MGC131954 | MTJ1DnaJ (Hsp40) homolog, subfamily C, member 1-HPRD10777498 
DNAJC10DKFZp434J1813 | ERdj5 | JPDI | MGC104194DnaJ (Hsp40) homolog, subfamily C, member 10-HPRD,BioGRID12411443 
DPH1DPH2L | DPH2L1 | FLJ33211 | OVCA1DPH1 homolog (S. cerevisiae)-HPRD,BioGRID11013075 
EIF2AK3DKFZp781H1925 | HRI | PEK | PERK | WRSeukaryotic translation initiation factor 2-alpha kinase 3-HPRD,BioGRID11907036 
ERN1FLJ30999 | IRE1 | IRE1P | MGC163277 | MGC163279endoplasmic reticulum to nucleus signaling 1-HPRD,BioGRID12637535 
ERP29C12orf8 | ERp28 | ERp31 | PDI-DBendoplasmic reticulum protein 29-HPRD9492298 
F8AHF | DXS1253E | F8B | F8C | FVIII | HEMAcoagulation factor VIII, procoagulant component-HPRD9305856 
GRIA1GLUH1 | GLUR1 | GLURA | HBGR1 | MGC133252glutamate receptor, ionotropic, AMPA 1-HPRD10461883 
HLA-CD6S204 | FLJ27082 | HLA-Cw | HLA-Cw12 | HLA-JY3 | HLC-C | PSORS1major histocompatibility complex, class I, C-HPRD,BioGRID7957306 
HTR3A5-HT-3 | 5-HT3A | 5-HT3R | 5HT3R | HTR35-hydroxytryptamine (serotonin) receptor 3A-HPRD12359150 
IGHMDKFZp686I15196 | DKFZp686I15212 | FLJ00385 | MGC104996 | MGC52291 | MU | VHimmunoglobulin heavy constant mu-HPRD3122216 
KRT18CYK18 | K18keratin 18-HPRD9409741 
KRT8CARD2 | CK8 | CYK8 | K2C8 | K8 | KOkeratin 8-HPRD,BioGRID9409741 
LCTLAC | LPH | LPH1lactase-HPRD,BioGRID11751874 
LDLRFH | FHClow density lipoprotein receptor-HPRD,BioGRID10906332 
MAP3K7TAK1 | TGF1amitogen-activated protein kinase kinase kinase 7-HPRD14743216 
MAP3K7IP2FLJ21885 | KIAA0733 | TAB2mitogen-activated protein kinase kinase kinase 7 interacting protein 2-HPRD14743216 
PCSK7LPC | PC7 | PC8 | SPC7proprotein convertase subtilisin/kexin type 7-HPRD,BioGRID10964928 
PRNPASCR | CD230 | CJD | GSS | MGC26679 | PRIP | PrP | PrP27-30 | PrP33-35C | PrPc | prionprion proteinPrPc interacts with HSPA5 (BiP).BIND10970892 
PSME3Ki | PA28-gamma | PA28G | REG-GAMMAproteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)Two-hybridBioGRID16169070 
SIL1BAP | MSS | ULG5SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)-HPRD,BioGRID12356756 
STMN1LAP18 | Lag | OP18 | PP17 | PP19 | PR22 | SMNstathmin 1/oncoprotein 18-HPRD,BioGRID7724523 |10197448 
TCERG1CA150 | MGC133200 | TAF2Stranscription elongation regulator 1-HPRD,BioGRID15456888 
TGAITD3 | TGNthyroglobulin-HPRD,BioGRID10049727 |11294872 
TMEM132ADKFZp547E212 | FLJ20539 | GBP | HSPA5BP1 | MGC138669transmembrane protein 132A-HPRD,BioGRID12514190 
TRA@FLJ22602 | MGC117436 | MGC22624 | MGC23964 | MGC71411 | TCRA | TCRD | TRAT cell receptor alpha locus-HPRD1649196 
TSHRCHNG1 | LGR3 | MGC75129 | hTSHR-Ithyroid stimulating hormone receptorTSHR interacts with BiP. This interaction was modeled on a demonstrated interaction between human TSHR and hamster BiP.BIND12383251 
-HPRD,BioGRID12383251 
VWFF8VWF | VWDvon Willebrand factor-HPRD,BioGRID10887119 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PROTEIN_EXPORT 2416All SZGR genes in this pathway
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 8965All SZGR genes in this pathway
KEGG_PRION_DISEASES 3528All SZGR genes in this pathway
REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 8956All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_PERK_REGULATED_GENE_EXPRESSION 2914All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA 139All SZGR genes in this pathway
REACTOME_UNFOLDED_PROTEIN_RESPONSE 8051All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA 118All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC 2117All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
NOJIMA_SFRP2_TARGETS_UP 3123All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP 204140All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_DN 214133All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_DN 4834All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_UP 8858All SZGR genes in this pathway
LI_AMPLIFIED_IN_LUNG_CANCER 178108All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
NEBEN_AML_WITH_FLT3_OR_NRAS_DN 126All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_DN 156106All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
DEN_INTERACT_WITH_LCA5 2621All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
SAKAI_TUMOR_INFILTRATING_MONOCYTES_DN 8151All SZGR genes in this pathway
MORI_EMU_MYC_LYMPHOMA_BY_ONSET_TIME_DN 179All SZGR genes in this pathway
GOTTWEIN_TARGETS_OF_KSHV_MIR_K12_11 6345All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_UP 7851All SZGR genes in this pathway
ROSS_AML_WITH_PML_RARA_FUSION 7762All SZGR genes in this pathway
UEDA_CENTRAL_CLOCK 8862All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP 14591All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_DN 187122All SZGR genes in this pathway
CHEN_LUNG_CANCER_SURVIVAL 2822All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_DN 6340All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_DN 245154All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN 337230All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
ADDYA_ERYTHROID_DIFFERENTIATION_BY_HEMIN 7347All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_UP 7856All SZGR genes in this pathway
MUNSHI_MULTIPLE_MYELOMA_UP 8152All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D 7962All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_UP 175116All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN 165106All SZGR genes in this pathway
RAMPON_ENRICHED_LEARNING_ENVIRONMENT_EARLY_UP 1512All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_UP 202115All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C7 6844All SZGR genes in this pathway
MARCHINI_TRABECTEDIN_RESISTANCE_DN 4934All SZGR genes in this pathway
PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_UP 6440All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN 354216All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
HONMA_DOCETAXEL_RESISTANCE 3423All SZGR genes in this pathway
BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_UP 12568All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_DN 1714All SZGR genes in this pathway
NGO_MALIGNANT_GLIOMA_1P_LOH 1713All SZGR genes in this pathway
WINNEPENNINCKX_MELANOMA_METASTASIS_UP 16286All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_11 10368All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
WIERENGA_PML_INTERACTOME 4223All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-18184901Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-199345351m8hsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-30-5p142148m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-37841471Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
miR-3793093151Ahsa-miR-379brainUGGUAGACUAUGGAACGUA
miR-4953343411A,m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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