Gene Page: NMNAT3
Summary ?
| GeneID | 349565 |
| Symbol | NMNAT3 |
| Synonyms | FKSG76|PNAT-3|PNAT3 |
| Description | nicotinamide nucleotide adenylyltransferase 3 |
| Reference | MIM:608702|HGNC:HGNC:20989|Ensembl:ENSG00000163864|HPRD:16370|Vega:OTTHUMG00000159951 |
| Gene type | protein-coding |
| Map location | 3q23 |
| Pascal p-value | 0.043 |
| Sherlock p-value | 0.124 |
| eGene | Anterior cingulate cortex BA24 Cerebellar Hemisphere Cerebellum Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10975953 | chr9 | 6996620 | NMNAT3 | 349565 | 0.16 | trans | ||
| rs9822952 | 3 | 139385257 | NMNAT3 | ENSG00000163864.10 | 7.895E-7 | 0.01 | 11602 | gtex_brain_ba24 |
| rs7639511 | 3 | 139392368 | NMNAT3 | ENSG00000163864.10 | 6.791E-7 | 0.01 | 4491 | gtex_brain_ba24 |
| rs6798004 | 3 | 139392922 | NMNAT3 | ENSG00000163864.10 | 1.441E-6 | 0.01 | 3937 | gtex_brain_ba24 |
| rs6785099 | 3 | 139392951 | NMNAT3 | ENSG00000163864.10 | 6.791E-7 | 0.01 | 3908 | gtex_brain_ba24 |
| rs4327348 | 3 | 139414375 | NMNAT3 | ENSG00000163864.10 | 1.416E-6 | 0.01 | -17516 | gtex_brain_ba24 |
| rs4532089 | 3 | 139418599 | NMNAT3 | ENSG00000163864.10 | 2.167E-6 | 0.01 | -21740 | gtex_brain_ba24 |
| rs4640518 | 3 | 139420246 | NMNAT3 | ENSG00000163864.10 | 2.354E-6 | 0.01 | -23387 | gtex_brain_ba24 |
| rs7648532 | 3 | 139429937 | NMNAT3 | ENSG00000163864.10 | 2.382E-6 | 0.01 | -33078 | gtex_brain_ba24 |
| rs4683684 | 3 | 139438653 | NMNAT3 | ENSG00000163864.10 | 3.666E-7 | 0.01 | -41794 | gtex_brain_ba24 |
| rs7649565 | 3 | 139440620 | NMNAT3 | ENSG00000163864.10 | 3.656E-7 | 0.01 | -43761 | gtex_brain_ba24 |
| rs7619522 | 3 | 139442437 | NMNAT3 | ENSG00000163864.10 | 4.123E-7 | 0.01 | -45578 | gtex_brain_ba24 |
| rs9838164 | 3 | 139445900 | NMNAT3 | ENSG00000163864.10 | 3.656E-7 | 0.01 | -49041 | gtex_brain_ba24 |
| rs13073922 | 3 | 139449872 | NMNAT3 | ENSG00000163864.10 | 3.656E-7 | 0.01 | -53013 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG NICOTINATE AND NICOTINAMIDE METABOLISM | 24 | 16 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF VITAMINS AND COFACTORS | 51 | 36 | All SZGR 2.0 genes in this pathway |
| KOYAMA SEMA3B TARGETS DN | 411 | 249 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS UP | 566 | 371 | All SZGR 2.0 genes in this pathway |
| ACEVEDO METHYLATED IN LIVER CANCER DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
| NOUSHMEHR GBM SILENCED BY METHYLATION | 50 | 32 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE EARLY LATE | 317 | 190 | All SZGR 2.0 genes in this pathway |