Gene Page: IL5

Summary
GeneID  3567
Symbol  IL5
Synonyms  EDF|IL-5|TRF
Description  interleukin 5 (colony-stimulating factor, eosinophil)
See related  HGNC:6016|MIM:147850|Ensembl:ENSG00000113525|HPRD:00997|
Locus tag  -
Gene type  protein-coding
Map location  5q31.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ABHD30.620.45
PYGL0.580.43
SCUBE20.540.40
MTMR110.530.43
GDPD20.530.40
SLC2A100.520.30
ITGB50.520.43
GPR10.520.20
PTN0.510.37
C18orf510.510.43
Top 10 negatively co-expressed genes
GPR22-0.27-0.23
SORCS1-0.27-0.28
KLHL1-0.26-0.21
IER5L-0.26-0.26
LMO7-0.26-0.22
PPM1L-0.26-0.25
GPR21-0.25-0.26
MYT1L-0.25-0.25
NDRG1-0.25-0.22
C1orf96-0.25-0.24
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005125cytokine activityIEA-
GO:0005137interleukin-5 receptor bindingTAS3024129 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006955immune responseIEA-
GO:0006954inflammatory responseTAS3498940 
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceTAS3024129 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
IL5EDF | IL-5 | TRFinterleukin 5 (colony-stimulating factor, eosinophil)-HPRD,BioGRID2361960 |7534492 
|8483502 
IL5RACD125 | CDw125 | HSIL5R3 | IL5R | MGC26560interleukin 5 receptor, alphaIL5R-alpha interacts with IL5.BIND1495999 
-HPRD1732409 |7721873 
|10880230 
Co-fractionation
in vitro
in vivo
Reconstituted Complex		BioGRID1732409 |7721873 
|7957082 
STAT5AMGF | STAT5signal transducer and activator of transcription 5ASTAT5A interacts with IL-5 promoter.BIND15735688 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_JAK_STAT_SIGNALING_PATHWAY 155105All SZGR genes in this pathway
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 7958All SZGR genes in this pathway
KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION 4836All SZGR genes in this pathway
KEGG_ASTHMA 3025All SZGR genes in this pathway
KEGG_AUTOIMMUNE_THYROID_DISEASE 5349All SZGR genes in this pathway
KEGG_ALLOGRAFT_REJECTION 3834All SZGR genes in this pathway
BIOCARTA_CYTOKINE_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_INFLAM_PATHWAY 2924All SZGR genes in this pathway
BIOCARTA_DC_PATHWAY 2220All SZGR genes in this pathway
BIOCARTA_GATA3_PATHWAY 1615All SZGR genes in this pathway
BIOCARTA_IL5_PATHWAY 109All SZGR genes in this pathway
BIOCARTA_STEM_PATHWAY 1513All SZGR genes in this pathway
BIOCARTA_NKT_PATHWAY 2921All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
PID_IL4_2PATHWAY 6543All SZGR genes in this pathway
PID_NFAT_TFPATHWAY 4739All SZGR genes in this pathway
PID_REG_GR_PATHWAY 8260All SZGR genes in this pathway
PID_IL5_PATHWAY 1411All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 4334All SZGR genes in this pathway
REACTOME_IL_RECEPTOR_SHC_SIGNALING 2721All SZGR genes in this pathway
REACTOME_IL_2_SIGNALING 4134All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
DEBOSSCHER_NFKB_TARGETS_REPRESSED_BY_GLUCOCORTICOIDS 2418All SZGR genes in this pathway
FUNG_IL2_SIGNALING_2 128All SZGR genes in this pathway
FUNG_IL2_TARGETS_WITH_STAT5_BINDING_SITES_T1 97All SZGR genes in this pathway
OKUMURA_INFLAMMATORY_RESPONSE_LPS 183115All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_UP 11580All SZGR genes in this pathway
WORSCHECH_TUMOR_REJECTION_UP 5632All SZGR genes in this pathway
BUDHU_LIVER_CANCER_METASTASIS_UP 107All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_DN 3619All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_DN 8859All SZGR genes in this pathway
BOSCO_ALLERGEN_INDUCED_TH2_ASSOCIATED_MODULE 15186All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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