SZGR2

Summary ?

GeneID	3692
Symbol	EIF6
Synonyms	CAB\|EIF3A\|ITGB4BP\|b(2)gcn\|eIF-6\|p27(BBP)\|p27BBP
Description	eukaryotic translation initiation factor 6
Reference	MIM:602912\|HGNC:HGNC:6159\|Ensembl:ENSG00000242372\|HPRD:04221\|Vega:OTTHUMG00000032328
Gene type	protein-coding
Map location	20q12
Pascal p-value	0.177
Sherlock p-value	0.497
Fetal beta	0.337

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PheWAS	Phenome-wide association studies (PheWAS)	157 SNPs associated with schizophrenia	1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.1714

Section I. Genetics and epigenetics annotation

CV:PheWAS

SNP ID	Chromosome	Position	Allele	P	Function	Gene	Up/Down Distance
rs619865	20	33867697	null	1.752	EIF6	null

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
C3orf63	0.90	0.91
WDR44	0.90	0.91
IBTK	0.88	0.90
HERC4	0.88	0.90
ZMYND11	0.87	0.89
EDEM3	0.87	0.89
MGEA5	0.87	0.88
MORC3	0.87	0.89
DNAJC10	0.87	0.89
RABEP1	0.87	0.89

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
FXYD1	-0.68	-0.70
MT-CO2	-0.68	-0.72
AF347015.31	-0.67	-0.71
HIGD1B	-0.65	-0.71
ENHO	-0.65	-0.76
AF347015.21	-0.65	-0.67
AF347015.33	-0.64	-0.66
IFI27	-0.64	-0.68
AF347015.8	-0.63	-0.69
MT-CYB	-0.63	-0.67

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003743	translation initiation factor activity	IEA		-
GO:0005515	protein binding	IPI		15231747 \|17353931
GO:0043022	ribosome binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006412	translation	IEA		-
GO:0042256	mature ribosome assembly	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	TAS		9374518
GO:0005638	lamin filament	IEA		-
GO:0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABCF1	ABC27 \| ABC50	ATP-binding cassette, sub-family F (GCN20), member 1	Two-hybrid	BioGRID	16169070
ACAP3	CENTB5 \| KIAA1716	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	Two-hybrid	BioGRID	16169070
ACTG1	ACT \| ACTG \| DFNA20 \| DFNA26	actin, gamma 1	Two-hybrid	BioGRID	16169070
AKT1S1	Lobe \| MGC2865 \| PRAS40	AKT1 substrate 1 (proline-rich)	Two-hybrid	BioGRID	16169070
ALDH2	ALDH-E2 \| ALDHI \| ALDM \| MGC1806	aldehyde dehydrogenase 2 family (mitochondrial)	Two-hybrid	BioGRID	16169070
ARF6	DKFZp564M0264	ADP-ribosylation factor 6	Affinity Capture-MS	BioGRID	17353931
BCCIP	TOK-1 \| TOK1	BRCA2 and CDKN1A interacting protein	Affinity Capture-MS	BioGRID	17353931
C1orf103	FLJ11269 \| RIF1 \| RP11-96K19.1	chromosome 1 open reading frame 103	Two-hybrid	BioGRID	16169070
C4orf27	FLJ20534 \| FLJ33423 \| FLJ42042	chromosome 4 open reading frame 27	Two-hybrid	BioGRID	16169070
CRELD1	AVSD2 \| CIRRIN \| DKFZp566D213	cysteine-rich with EGF-like domains 1	Two-hybrid	BioGRID	16169070
EIF3B	EIF3-ETA \| EIF3-P110 \| EIF3-P116 \| EIF3S9 \| MGC104664 \| MGC131875 \| PRT1	eukaryotic translation initiation factor 3, subunit B	Co-purification	BioGRID	15946946
EIF3C	EIF3S8 \| FLJ78287 \| MGC189744 \| eIF3-p110	eukaryotic translation initiation factor 3, subunit C	Co-purification	BioGRID	15946946
EIF3J	EIF3S1 \| eIF3-alpha \| eIF3-p35	eukaryotic translation initiation factor 3, subunit J	Co-purification	BioGRID	15946946
ENOX1	CNOX \| FLJ10094 \| PIG38 \| bA64J21.1 \| cCNOX	ecto-NOX disulfide-thiol exchanger 1	Two-hybrid	BioGRID	16169070
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	Affinity Capture-Western Two-hybrid	BioGRID	10906324
FIBP	FGFIBP \| FIBP-1	fibroblast growth factor (acidic) intracellular binding protein	Affinity Capture-MS	BioGRID	17353931
FUNDC2	DC44 \| FLJ33773 \| HCBP6 \| HCC3 \| MGC131676 \| MGC2495 \| PD03104	FUN14 domain containing 2	Two-hybrid	BioGRID	16169070
FUS	CHOP \| FUS-CHOP \| FUS1 \| TLS \| TLS/CHOP \| hnRNP-P2	fusion (involved in t(12;16) in malignant liposarcoma)	Affinity Capture-MS	BioGRID	17353931
GIT1	-	G protein-coupled receptor kinase interacting ArfGAP 1	Two-hybrid	BioGRID	16169070
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	-	HPRD,BioGRID	14654845
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	eIF6 interacts with RACK1	BIND	14654845
GTPBP4	CRFG \| FLJ10686 \| FLJ10690 \| FLJ39774 \| NGB \| NOG1	GTP binding protein 4	Affinity Capture-MS	BioGRID	17353931
HAS1	HAS	hyaluronan synthase 1	Affinity Capture-MS	BioGRID	17353931
HIP1	ILWEQ \| MGC126506	huntingtin interacting protein 1	Two-hybrid	BioGRID	16169070
ITGB4	CD104	integrin, beta 4	-	HPRD,BioGRID	9374518
KIAA1377	-	KIAA1377	Two-hybrid	BioGRID	16169070
LOC387753	-	similar to 60S ribosomal protein L21	Affinity Capture-MS	BioGRID	17353931
MRPS31	IMOGN38 \| MRP-S31 \| S31mt	mitochondrial ribosomal protein S31	Two-hybrid	BioGRID	16169070
NPEPPS	MP100 \| PSA	aminopeptidase puromycin sensitive	Affinity Capture-MS	BioGRID	17353931
OAT	DKFZp781A11155 \| HOGA	ornithine aminotransferase (gyrate atrophy)	Affinity Capture-MS	BioGRID	17353931
OFD1	71-7A \| CXorf5 \| MGC117039 \| MGC117040 \| SGBS2	oral-facial-digital syndrome 1	Two-hybrid	BioGRID	16169070
PAICS	ADE2 \| ADE2H1 \| AIRC \| DKFZp781N1372 \| MGC1343 \| MGC5024 \| PAIS	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	Affinity Capture-MS	BioGRID	17353931
PDHA1	PDHA \| PDHCE1A \| PHE1A	pyruvate dehydrogenase (lipoamide) alpha 1	Two-hybrid	BioGRID	16169070
POLA2	FLJ21662 \| FLJ37250	polymerase (DNA directed), alpha 2 (70kD subunit)	Two-hybrid	BioGRID	16169070
PRKCB	MGC41878 \| PKC-beta \| PKCB \| PRKCB1 \| PRKCB2	protein kinase C, beta	-	HPRD	14654845
PSME1	IFI5111 \| MGC8628 \| PA28A \| PA28alpha \| REGalpha	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)	Two-hybrid	BioGRID	16169070
RGS10	-	regulator of G-protein signaling 10	Affinity Capture-MS	BioGRID	17353931
RPL3	MGC104284 \| TARBP-B	ribosomal protein L3	Affinity Capture-MS	BioGRID	17353931
RPL34	MGC111005	ribosomal protein L34	Affinity Capture-MS	BioGRID	17353931
RPL6	SHUJUN-2 \| TAXREB107 \| TXREB1	ribosomal protein L6	Two-hybrid	BioGRID	16169070
RRP15	CGI-115 \| KIAA0507 \| MGC22291	ribosomal RNA processing 15 homolog (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
SEPT3	MGC133218 \| SEP3 \| bK250D10.3	septin 3	Two-hybrid	BioGRID	16169070
SORBS1	CAP \| DKFZp451C066 \| DKFZp586P1422 \| FLAF2 \| FLJ12406 \| KIAA1296 \| R85FL \| SH3D5 \| SH3P12 \| SORB1	sorbin and SH3 domain containing 1	Affinity Capture-MS	BioGRID	17353931
UPF3B	HUPF3B \| MRXS14 \| RENT3B \| UPF3X	UPF3 regulator of nonsense transcripts homolog B (yeast)	Two-hybrid	BioGRID	16169070
USP33	KIAA1097 \| MGC16868 \| VDU1	ubiquitin specific peptidase 33	Two-hybrid	BioGRID	16169070
WFS1	DFNA14 \| DFNA38 \| DFNA6 \| DIDMOAD \| WFRS \| WFS \| WOLFRAMIN	Wolfram syndrome 1 (wolframin)	Two-hybrid	BioGRID	16169070
YARS	CMTDIC \| TYRRS \| YRS \| YTS	tyrosyl-tRNA synthetase	Affinity Capture-MS	BioGRID	17353931

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
BIOCARTA EIF PATHWAY	16	9	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN	126	86	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 DN	77	46	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN	162	116	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN	517	309	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 20Q11 AMPLICON	31	18	All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP	197	110	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
MOREIRA RESPONSE TO TSA UP	28	23	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS INTERMEDIATE PROGENITOR	149	84	All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN	161	105	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP	285	167	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS DURATION CORR DN	146	90	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway

Gene Page: EIF6