Gene Page: ITIH4

Summary ?
GeneID3700
SymbolITIH4
SynonymsGP120|H4P|IHRP|ITI-HC4|ITIHL1|PK-120|PK120
Descriptioninter-alpha-trypsin inhibitor heavy chain family member 4
ReferenceMIM:600564|HGNC:HGNC:6169|Ensembl:ENSG00000055955|HPRD:02781|Vega:OTTHUMG00000159023
Gene typeprotein-coding
Map location3p21.1
Pascal p-value1.521E-10
Sherlock p-value0.118
Fetal beta-0.564
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGC128Genome-wide Association StudyA multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnpGenome-wide Association StudyGWAS
LK:YESGenome-wide Association StudyThis data set included 99 genes mapped to the 22 regions. The 24 leading SNPs were also included in CV:Ripke_2013
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@CV:PGC128

SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance
rs2535627chr352845105TC3.956E-11intergenicITIH3,ITIH4dist=2080;dist=1901

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1961958chr352585989ITIH437000.18cis
rs6778844chr352596397ITIH437000.02cis
rs2336545chr352787602ITIH437000.18cis
rs2240920chr352831008ITIH437000.1cis
rs2276817chr352860935ITIH437000cis
rs3733047chr352871928ITIH437000.03cis
rs6803519chr352889770ITIH437000cis
rs2581815chr352982158ITIH437000.01cis
rs2336669chr352994137ITIH437000.01cis
rs4519686chr352997870ITIH437000.04cis
rs17304995chr353070754ITIH437000.01cis
rs2276817chr352860935ITIH437000.11trans
rs6803519chr352889770ITIH437000.19trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
DDIT40.690.45
KDM3A0.660.58
TMPO0.660.55
HIST2H2BE0.650.56
ZFP36L10.650.57
HES10.640.43
MCL10.640.61
VEGFA0.640.53
ZNF1430.630.52
SORD0.630.56
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CLDND2-0.40-0.47
C5orf53-0.40-0.46
AF347015.21-0.39-0.49
IFI27-0.39-0.44
MT-CO2-0.37-0.45
AF347015.27-0.36-0.44
AF347015.31-0.36-0.42
C1orf54-0.36-0.44
PSMB9-0.35-0.37
HIGD1B-0.35-0.41

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
CORRE MULTIPLE MYELOMA UP 7445All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL UP 9564All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS DN 1611All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN 228146All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
LEE LIVER CANCER 4929All SZGR 2.0 genes in this pathway
STEARMAN TUMOR FIELD EFFECT UP 3622All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP 12589All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G123 DN 5130All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267160All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES DN 210141All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222141All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238125All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway