Gene Page: MAPT

Summary
GeneID  4137
Symbol  MAPT
Synonyms  DDPAC|FLJ31424|FTDP-17|MAPTL|MGC138549|MSTD|MTBT1|MTBT2|PPND|TAU
Description  microtubule-associated protein tau
See related  HGNC:6893|MIM:157140|Ensembl:ENSG00000186868|HPRD:01142|
Locus tag  -
Gene type  protein-coding
Map location  17q21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 8 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 3.6916 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TNS10.830.86
TLN10.800.81
RRBP10.790.83
SLC20A20.780.82
GSN0.770.78
ANGPTL20.770.79
TJP20.770.82
UNC5B0.770.80
MYLK0.770.79
ERBB30.770.77
Top 10 negatively co-expressed genes
NR2C2AP-0.53-0.56
RPL27-0.52-0.67
RPL31-0.52-0.66
POLB-0.52-0.58
RPS23-0.52-0.66
FRG1-0.52-0.61
RPL24-0.52-0.68
CYP2R1-0.52-0.57
RPS18-0.52-0.64
RPL32-0.51-0.64
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005200structural constituent of cytoskeletonTAS2498079 
GO:0008034lipoprotein bindingIPI7972031 
GO:0017124SH3 domain bindingIPI9763511 
GO:0008017microtubule bindingIDA1918161 
GO:0008017microtubule bindingISS-
GO:0019899enzyme bindingIPI9736630 |12888622 
GO:0034187apolipoprotein E bindingIPI7566652 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0048699generation of neuronsNASneuron, neurogenesis (GO term level: 7)8522593 
GO:0045773positive regulation of axon extensionIDAaxon (GO term level: 15)1389180 
GO:0045773positive regulation of axon extensionISSaxon (GO term level: 15)-
GO:0000226microtubule cytoskeleton organizationIDA1057175 
GO:0000226microtubule cytoskeleton organizationISS-
GO:0007026negative regulation of microtubule depolymerizationIEA-
GO:0031116positive regulation of microtubule polymerizationIDA1421571 
GO:0031116positive regulation of microtubule polymerizationISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0030426growth coneIDAaxon, dendrite (GO term level: 5)8642405 
GO:0030426growth coneISSaxon, dendrite (GO term level: 5)-
GO:0030424axonIDAneuron, axon, Neurotransmitter (GO term level: 6)8642405 
GO:0030424axonISSneuron, axon, Neurotransmitter (GO term level: 6)-
GO:0005829cytosolTAS10747907 
GO:0005856cytoskeletonIEA-
GO:0005875microtubule associated complexTAS10747907 
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneIDA8522593 
GO:0005886plasma membraneISS-
GO:0045298tubulin complexIDA8642405 
GO:0045298tubulin complexISS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AATFCHE-1 | CHE1 | DEDapoptosis antagonizing transcription factor-HPRD,BioGRID14697667 
APOEAD2 | LPG | MGC1571 | apoproteinapolipoprotein EReconstituted ComplexBioGRID8620924 
-HPRD7566652 |9147408 
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)-HPRD,BioGRID2123288 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID11826099 
GSK3B-glycogen synthase kinase 3 betaGSK3beta phosphorylates Ftau.This interaction was modelled on a demonstrated interaction between rabbit GSK3beta and human Ftau.BIND14636947 
MARK4FLJ90097 | KIAA1860 | MARKL1 | Nbla00650MAP/microtubule affinity-regulating kinase 4-HPRD,BioGRID14594945 
OGTFLJ23071 | HRNT1 | MGC22921 | O-GLCNACO-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)-HPRD,BioGRID8910513 |12911634 
PIN1DOD | UBL5peptidylprolyl cis/trans isomerase, NIMA-interacting 1-HPRD,BioGRID10391244 
PSEN1AD3 | FAD | PS1 | S182presenilin 1-HPRD,BioGRID9689133 
S100BNEF | S100 | S100betaS100 calcium binding protein B-HPRD11264299 
-HPRD,BioGRID2833519 
SNCAMGC110988 | NACP | PARK1 | PARK4 | PD1synuclein, alpha (non A4 component of amyloid precursor)-HPRD,BioGRID10464279 
SPTBHSpTB1spectrin, beta, erythrocytic-HPRD,BioGRID6743699 
STXBP1EIEE4 | MUNC18-1 | UNC18 | hUNC18 | rbSec1syntaxin binding protein 1-HPRD,BioGRID12963086 
TUBB2ATUBB | TUBB2 | dJ40E16.7tubulin, beta 2A-HPRD9922135 
USP9YAZF | AZF1 | AZFA | DFFRY | FLJ33043 | SP3ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila)-HPRD,BioGRID1723470 
YWHAA-tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptideAffinity Capture-WesternBioGRID12176984 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide-HPRD,BioGRID10840038 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideTau interacts with 14-3-3-zeta.BIND12176984 
-HPRD,BioGRID10840038 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
BIOCARTA_BIOPEPTIDES_PATHWAY 4535All SZGR genes in this pathway
BIOCARTA_P35ALZHEIMERS_PATHWAY 119All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY 6653All SZGR genes in this pathway
PID_REELIN_PATHWAY 2929All SZGR genes in this pathway
PID_LKB1_PATHWAY 4737All SZGR genes in this pathway
PID_P38_GAMMA_DELTA_PATHWAY 119All SZGR genes in this pathway
REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 4026All SZGR genes in this pathway
REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS 1311All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_APOPTOTIC_EXECUTION_PHASE 5437All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_DN 244147All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP 380215All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
DOANE_BREAST_CANCER_ESR1_UP 11272All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_UP 11966All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_UP 13493All SZGR genes in this pathway
TERAMOTO_OPN_TARGETS_CLUSTER_8 87All SZGR genes in this pathway
YANG_BREAST_CANCER_ESR1_UP 3622All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_DN 160110All SZGR genes in this pathway
FRASOR_RESPONSE_TO_ESTRADIOL_UP 3728All SZGR genes in this pathway
ZHANG_TARGETS_OF_EWSR1_FLI1_FUSION 8868All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM 302191All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
CUI_TCF21_TARGETS_DN 3123All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_UP 9564All SZGR genes in this pathway
MCDOWELL_ACUTE_LUNG_INJURY_DN 4833All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
KONDO_PROSTATE_CANCER_HCP_WITH_H3K27ME3 9772All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_DN 4531All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_DN 258160All SZGR genes in this pathway
MASSARWEH_RESPONSE_TO_ESTRADIOL 6147All SZGR genes in this pathway
OUILLETTE_CLL_13Q14_DELETION_DN 6038All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BRAIN_DN 8558All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_DN 5839All SZGR genes in this pathway
HUANG_DASATINIB_RESISTANCE_DN 6944All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_UP 3624All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN 13483All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_UP 229149All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP 281183All SZGR genes in this pathway
FARDIN_HYPOXIA_11 3229All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP 271165All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_A 182108All SZGR genes in this pathway
GHANDHI_BYSTANDER_IRRADIATION_DN 1210All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-18140684074m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-21420392045m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-21931753181m8hsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-27406540711Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-34/44911871193m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.