Gene Page: MAP3K3

Summary
GeneID  4215
Symbol  MAP3K3
Synonyms  MAPKKK3|MEKK3
Description  mitogen-activated protein kinase kinase kinase 3
See related  HGNC:6855|MIM:602539|Ensembl:ENSG00000198909|HPRD:03965|
Locus tag  -
Gene type  protein-coding
Map location  17q23.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1421 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TTYH10.810.85
MLC10.790.83
ITGB50.770.78
BCAN0.760.79
S1PR10.750.78
RHOJ0.740.69
TNFRSF1A0.730.74
LRP100.730.79
SLC12A40.730.75
LAMB20.730.72
Top 10 negatively co-expressed genes
FAM49A-0.57-0.65
DYNC1I1-0.54-0.62
NELL2-0.54-0.65
GNAI1-0.53-0.63
GPR22-0.53-0.65
LRRC7-0.53-0.61
C1orf96-0.53-0.60
HERC3-0.52-0.60
ELMOD1-0.52-0.57
AGTPBP1-0.52-0.61
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0005515protein bindingIPI14743216 
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityIEA-
GO:0004709MAP kinase kinase kinase activityTAS9006902 
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000165MAPKKK cascadeTAS9006902 
GO:0006468protein amino acid phosphorylationIEA-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
GO:0046777protein amino acid autophosphorylationIDA15001576 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043234protein complexIDA11256614 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AIFM1AIF | MGC111425 | PDCD8apoptosis-inducing factor, mitochondrion-associated, 1-HPRD14743216 
AKAP8LDKFZp434L0650 | HA95 | HAP95 | NAKAP | NAKAP95A kinase (PRKA) anchor protein 8-like-HPRD14743216 
ATP5A1ATP5A | ATP5AL2 | ATPM | MOM2 | OMR | ORM | hATP1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle-HPRD14743216 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetAffinity Capture-Western
Two-hybrid		BioGRID15205325 
BRCA1 interacts with MEKK3.BIND15205325 
C19orf2FLJ10575 | NNX3 | RMP | URIchromosome 19 open reading frame 2-HPRD14743216 
CAPZBCAPB | CAPPB | CAPZ | MGC104401 | MGC129749 | MGC129750capping protein (actin filament) muscle Z-line, beta-HPRD14743216 
CCT6ACCT-zeta | CCT-zeta-1 | CCT6 | Cctz | HTR3 | MGC126214 | MGC126215 | MoDP-2 | TCP-1-zeta | TCP20 | TCPZ | TTCP20chaperonin containing TCP1, subunit 6A (zeta 1)-HPRD14743216 
CCT8C21orf112 | Cctq | D21S246 | KIAA0002 | PRED71chaperonin containing TCP1, subunit 8 (theta)-HPRD14743216 
CDC37P50CDC37cell division cycle 37 homolog (S. cerevisiae)Affinity Capture-MSBioGRID14743216 
DBN1D0S117E | DKFZp434D064drebrin 1-HPRD14743216 
DDB1DDBA | UV-DDB1 | XAP1 | XPCE | XPE | XPE-BFdamage-specific DNA binding protein 1, 127kDa-HPRD14743216 
GAB1-GRB2-associated binding protein 1-HPRD,BioGRID12065326 
GNB2-guanine nucleotide binding protein (G protein), beta polypeptide 2-HPRD14743216 
HAX1FLJ17042 | FLJ18492 | FLJ93803 | HCLSBP1 | HS1BP1 | SCN3HCLS1 associated protein X-1-HPRD14743216 
HSP90AA2HSP90ALPHA | HSPCA | HSPCAL3heat shock protein 90kDa alpha (cytosolic), class A member 2Affinity Capture-MSBioGRID14743216 
HSPA4APG-2 | HS24/P52 | MGC131852 | RY | hsp70 | hsp70RYheat shock 70kDa protein 4-HPRD,BioGRID14743216 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD14743216 
MAP2K5HsT17454 | MAPKK5 | MEK5 | PRKMK5mitogen-activated protein kinase kinase 5-HPRD,BioGRID10593883 |11073940 
MARK2EMK1 | MGC99619 | PAR-1 | Par1bMAP/microtubule affinity-regulating kinase 2-HPRD,BioGRID14743216 
MPRIPKIAA0864 | M-RIP | RHOIP3 | p116Ripmyosin phosphatase Rho interacting protein-HPRD14743216 
MRCL3MLCB | MRLC3myosin regulatory light chain MRCL3-HPRD14743216 
MYL6ESMLC | LC17-GI | LC17-NM | LC17A | LC17B | MLC1SM | MLC3NM | MLC3SMmyosin, light chain 6, alkali, smooth muscle and non-muscle-HPRD14743216 
NUDCHNUDC | MNUDC | NPD011nuclear distribution gene C homolog (A. nidulans)-HPRD14743216 
PDRG1C20orf126 | PDRGp53 and DNA damage regulated 1-HPRD,BioGRID14743216 
PFDN2PFD2prefoldin subunit 2Affinity Capture-MSBioGRID14743216 
PFDN6H2-KE2 | HKE2 | KE-2 | MGC70744 | PFD6prefoldin subunit 6-HPRD14743216 
PPP1CAMGC15877 | MGC1674 | PP-1A | PPP1Aprotein phosphatase 1, catalytic subunit, alpha isoform-HPRD14743216 
PPP2R1AMGC786 | PR65Aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform-HPRD14743216 
RIPK1FLJ39204 | RIP | RIP1receptor (TNFRSF)-interacting serine-threonine kinase 1-HPRD,BioGRID11429546 
RNF126FLJ20552 | MGC1022 | MGC14317ring finger protein 126-HPRD14743216 
RPS27L-ribosomal protein S27-like-HPRD14743216 
RUVBL2CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49BRuvB-like 2 (E. coli)-HPRD14743216 
SCINKIAA1905scinderin-HPRD14743216 
SCRIBCRIB1 | SCRB1 | SCRIB1 | Vartulscribbled homolog (Drosophila)-HPRD14743216 
SEC16AFLJ26737 | KIAA0310 | RP11-413M3.10 | SEC16L | p250SEC16 homolog A (S. cerevisiae)-HPRD14743216 
SMARCC2BAF170 | CRACC2 | Rsc8SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2-HPRD14743216 
SPAG9FLJ13450 | FLJ14006 | FLJ26141 | FLJ34602 | HLC4 | JLP | KIAA0516 | MGC117291 | MGC14967 | MGC74461 | PHET | PIG6sperm associated antigen 9-HPRD,BioGRID12391307 
SPTBN1ELF | SPTB2 | betaSpIIspectrin, beta, non-erythrocytic 1-HPRD14743216 
TIMM50MGC102733 | TIM50 | TIM50Ltranslocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)-HPRD14743216 
TMOD3UTMODtropomodulin 3 (ubiquitous)-HPRD14743216 
TRAF7DKFZp586I021 | MGC7807 | RFWD1 | RNF119TNF receptor-associated factor 7TRAF7 interacts with an unspecified isoform of MAP3K3 (MEKK3).BIND14743216 
Affinity Capture-MSBioGRID14743216 
TUBA3CTUBA2 | bA408E5.3tubulin, alpha 3c-HPRD14743216 
TUBB2BDKFZp566F223 | FLJ98847 | MGC8685 | TUBB-PARALOG | bA506K6.1tubulin, beta 2B-HPRD14743216 
TUBB6HsT1601 | MGC132410 | MGC4083 | TUBB-5tubulin, beta 6-HPRD14743216 
UACAFLJ10128 | KIAA1561 | MGC141967 | MGC141969 | NUCLINGuveal autoantigen with coiled-coil domains and ankyrin repeats-HPRD14743216 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide-HPRD,BioGRID9452471 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideAffinity Capture-MSBioGRID14743216 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide-HPRD9452471 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
ST_TUMOR_NECROSIS_FACTOR_PATHWAY 2920All SZGR genes in this pathway
ST_JNK_MAPK_PATHWAY 4030All SZGR genes in this pathway
PID_P38_MKK3_6PATHWAY 2621All SZGR genes in this pathway
PID_P38_ALPHA_BETA_PATHWAY 3125All SZGR genes in this pathway
PID_IL1_PATHWAY 3428All SZGR genes in this pathway
PID_TNF_PATHWAY 4633All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_IL1_SIGNALING 3930All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP 372227All SZGR genes in this pathway
SCHEIDEREIT_IKK_INTERACTING_PROTEINS 5845All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
TAGHAVI_NEOPLASTIC_TRANSFORMATION 1210All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON 335181All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
SUBTIL_PROGESTIN_TARGETS 3625All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JUBAN_TARGETS_OF_SPI1_AND_FLI1_UP 11573All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98198619921Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-1/206226922751Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-122204220481Ahsa-miR-122aUGGAGUGUGACAAUGGUGUUUGU
miR-124.1589595m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5065895951Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-133211521211Ahsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-141/200a3913971Ahsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-145760766m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-15/16/195/424/4977379m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d14521458m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-181146114681A,m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-182207820841Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-18825142520m8hsa-miR-188CAUCCCUUGCAUGGUGGAGGGU
miR-19324862492m8hsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
miR-1998808861Ahsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-204/21125132519m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-2218201826m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-2315051511m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-2812651271m8hsa-miR-28brainAAGGAGCUCACAGUCUAUUGAG
miR-323150415111A,m8hsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-33701707m8hsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-33820952101m8hsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
miR-363247524811Ahsa-miR-363AUUGCACGGUAUCCAUCUGUAA
miR-410155815641Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-49615001506m8hsa-miR-496AUUACAUGGCCAAUCUC
miR-95605671A,m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-96207720841A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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