SZGR2

Summary ?

GeneID	4215
Symbol	MAP3K3
Synonyms	MAPKKK3\|MEKK3
Description	mitogen-activated protein kinase kinase kinase 3
Reference	MIM:602539\|HGNC:HGNC:6855\|Ensembl:ENSG00000198909\|HPRD:03965\|Vega:OTTHUMG00000178905
Gene type	protein-coding
Map location	17q23.3
Pascal p-value	0.101
Sherlock p-value	0.301
Fetal beta	1.024
eGene	Myers' cis & trans
Support	Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.1421

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs16829545	chr2	151977407	MAP3K3	4215	3.101E-6	trans
rs16955618	chr15	29937543	MAP3K3	4215	1.392E-5	trans
rs7288523	chr22	50082517	MAP3K3	4215	0.16	trans
rs16993189	chrX	144666166	MAP3K3	4215	0.2	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
TTYH1	0.81	0.85
MLC1	0.79	0.83
ITGB5	0.77	0.78
BCAN	0.76	0.79
S1PR1	0.75	0.78
RHOJ	0.74	0.69
TNFRSF1A	0.73	0.74
LRP10	0.73	0.79
SLC12A4	0.73	0.75
LAMB2	0.73	0.72

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
FAM49A	-0.57	-0.65
DYNC1I1	-0.54	-0.62
NELL2	-0.54	-0.65
GNAI1	-0.53	-0.63
GPR22	-0.53	-0.65
LRRC7	-0.53	-0.61
C1orf96	-0.53	-0.60
HERC3	-0.52	-0.60
ELMOD1	-0.52	-0.57
AGTPBP1	-0.52	-0.61

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0000287	magnesium ion binding	IEA		-
GO:0005515	protein binding	IPI		14743216
GO:0005524	ATP binding	IEA		-
GO:0004674	protein serine/threonine kinase activity	IEA		-
GO:0004709	MAP kinase kinase kinase activity	TAS		9006902
GO:0016740	transferase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000165	MAPKKK cascade	TAS		9006902
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IEP		12761501
GO:0046777	protein amino acid autophosphorylation	IDA		15001576
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0043234	protein complex	IDA		11256614

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AIFM1	AIF \| MGC111425 \| PDCD8	apoptosis-inducing factor, mitochondrion-associated, 1	-	HPRD	14743216
AKAP8L	DKFZp434L0650 \| HA95 \| HAP95 \| NAKAP \| NAKAP95	A kinase (PRKA) anchor protein 8-like	-	HPRD	14743216
ATP5A1	ATP5A \| ATP5AL2 \| ATPM \| MOM2 \| OMR \| ORM \| hATP1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	-	HPRD	14743216
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	Affinity Capture-Western Two-hybrid	BioGRID	15205325
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	BRCA1 interacts with MEKK3.	BIND	15205325
C19orf2	FLJ10575 \| NNX3 \| RMP \| URI	chromosome 19 open reading frame 2	-	HPRD	14743216
CAPZB	CAPB \| CAPPB \| CAPZ \| MGC104401 \| MGC129749 \| MGC129750	capping protein (actin filament) muscle Z-line, beta	-	HPRD	14743216
CCT6A	CCT-zeta \| CCT-zeta-1 \| CCT6 \| Cctz \| HTR3 \| MGC126214 \| MGC126215 \| MoDP-2 \| TCP-1-zeta \| TCP20 \| TCPZ \| TTCP20	chaperonin containing TCP1, subunit 6A (zeta 1)	-	HPRD	14743216
CCT8	C21orf112 \| Cctq \| D21S246 \| KIAA0002 \| PRED71	chaperonin containing TCP1, subunit 8 (theta)	-	HPRD	14743216
CDC37	P50CDC37	cell division cycle 37 homolog (S. cerevisiae)	Affinity Capture-MS	BioGRID	14743216
DBN1	D0S117E \| DKFZp434D064	drebrin 1	-	HPRD	14743216
DDB1	DDBA \| UV-DDB1 \| XAP1 \| XPCE \| XPE \| XPE-BF	damage-specific DNA binding protein 1, 127kDa	-	HPRD	14743216
GAB1	-	GRB2-associated binding protein 1	-	HPRD,BioGRID	12065326
GNB2	-	guanine nucleotide binding protein (G protein), beta polypeptide 2	-	HPRD	14743216
HAX1	FLJ17042 \| FLJ18492 \| FLJ93803 \| HCLSBP1 \| HS1BP1 \| SCN3	HCLS1 associated protein X-1	-	HPRD	14743216
HSP90AA2	HSP90ALPHA \| HSPCA \| HSPCAL3	heat shock protein 90kDa alpha (cytosolic), class A member 2	Affinity Capture-MS	BioGRID	14743216
HSPA4	APG-2 \| HS24/P52 \| MGC131852 \| RY \| hsp70 \| hsp70RY	heat shock 70kDa protein 4	-	HPRD,BioGRID	14743216
HSPA8	HSC54 \| HSC70 \| HSC71 \| HSP71 \| HSP73 \| HSPA10 \| LAP1 \| MGC131511 \| MGC29929 \| NIP71	heat shock 70kDa protein 8	-	HPRD	14743216
MAP2K5	HsT17454 \| MAPKK5 \| MEK5 \| PRKMK5	mitogen-activated protein kinase kinase 5	-	HPRD,BioGRID	10593883 \|11073940
MARK2	EMK1 \| MGC99619 \| PAR-1 \| Par1b	MAP/microtubule affinity-regulating kinase 2	-	HPRD,BioGRID	14743216
MPRIP	KIAA0864 \| M-RIP \| RHOIP3 \| p116Rip	myosin phosphatase Rho interacting protein	-	HPRD	14743216
MRCL3	MLCB \| MRLC3	myosin regulatory light chain MRCL3	-	HPRD	14743216
MYL6	ESMLC \| LC17-GI \| LC17-NM \| LC17A \| LC17B \| MLC1SM \| MLC3NM \| MLC3SM	myosin, light chain 6, alkali, smooth muscle and non-muscle	-	HPRD	14743216
NUDC	HNUDC \| MNUDC \| NPD011	nuclear distribution gene C homolog (A. nidulans)	-	HPRD	14743216
PDRG1	C20orf126 \| PDRG	p53 and DNA damage regulated 1	-	HPRD,BioGRID	14743216
PFDN2	PFD2	prefoldin subunit 2	Affinity Capture-MS	BioGRID	14743216
PFDN6	H2-KE2 \| HKE2 \| KE-2 \| MGC70744 \| PFD6	prefoldin subunit 6	-	HPRD	14743216
PPP1CA	MGC15877 \| MGC1674 \| PP-1A \| PPP1A	protein phosphatase 1, catalytic subunit, alpha isoform	-	HPRD	14743216
PPP2R1A	MGC786 \| PR65A	protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform	-	HPRD	14743216
RIPK1	FLJ39204 \| RIP \| RIP1	receptor (TNFRSF)-interacting serine-threonine kinase 1	-	HPRD,BioGRID	11429546
RNF126	FLJ20552 \| MGC1022 \| MGC14317	ring finger protein 126	-	HPRD	14743216
RPS27L	-	ribosomal protein S27-like	-	HPRD	14743216
RUVBL2	CGI-46 \| ECP51 \| INO80J \| REPTIN \| RVB2 \| TIH2 \| TIP48 \| TIP49B	RuvB-like 2 (E. coli)	-	HPRD	14743216
SCIN	KIAA1905	scinderin	-	HPRD	14743216
SCRIB	CRIB1 \| SCRB1 \| SCRIB1 \| Vartul	scribbled homolog (Drosophila)	-	HPRD	14743216
SEC16A	FLJ26737 \| KIAA0310 \| RP11-413M3.10 \| SEC16L \| p250	SEC16 homolog A (S. cerevisiae)	-	HPRD	14743216
SMARCC2	BAF170 \| CRACC2 \| Rsc8	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	-	HPRD	14743216
SPAG9	FLJ13450 \| FLJ14006 \| FLJ26141 \| FLJ34602 \| HLC4 \| JLP \| KIAA0516 \| MGC117291 \| MGC14967 \| MGC74461 \| PHET \| PIG6	sperm associated antigen 9	-	HPRD,BioGRID	12391307
SPTBN1	ELF \| SPTB2 \| betaSpII	spectrin, beta, non-erythrocytic 1	-	HPRD	14743216
TIMM50	MGC102733 \| TIM50 \| TIM50L	translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)	-	HPRD	14743216
TMOD3	UTMOD	tropomodulin 3 (ubiquitous)	-	HPRD	14743216
TRAF7	DKFZp586I021 \| MGC7807 \| RFWD1 \| RNF119	TNF receptor-associated factor 7	TRAF7 interacts with an unspecified isoform of MAP3K3 (MEKK3).	BIND	14743216
TRAF7	DKFZp586I021 \| MGC7807 \| RFWD1 \| RNF119	TNF receptor-associated factor 7	Affinity Capture-MS	BioGRID	14743216
TUBA3C	TUBA2 \| bA408E5.3	tubulin, alpha 3c	-	HPRD	14743216
TUBB2B	DKFZp566F223 \| FLJ98847 \| MGC8685 \| TUBB-PARALOG \| bA506K6.1	tubulin, beta 2B	-	HPRD	14743216
TUBB6	HsT1601 \| MGC132410 \| MGC4083 \| TUBB-5	tubulin, beta 6	-	HPRD	14743216
UACA	FLJ10128 \| KIAA1561 \| MGC141967 \| MGC141969 \| NUCLING	uveal autoantigen with coiled-coil domains and ankyrin repeats	-	HPRD	14743216
YWHAE	14-3-3E \| FLJ45465 \| KCIP-1 \| MDCR \| MDS	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	-	HPRD,BioGRID	9452471
YWHAG	14-3-3GAMMA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Affinity Capture-MS	BioGRID	14743216
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	-	HPRD	9452471
ZBTB16	PLZF \| ZNF145	zinc finger and BTB domain containing 16	Two-hybrid	BioGRID	16169070

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY	101	77	All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY	87	68	All SZGR 2.0 genes in this pathway
ST TUMOR NECROSIS FACTOR PATHWAY	29	20	All SZGR 2.0 genes in this pathway
ST JNK MAPK PATHWAY	40	30	All SZGR 2.0 genes in this pathway
PID P38 MKK3 6PATHWAY	26	21	All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY	31	25	All SZGR 2.0 genes in this pathway
PID IL1 PATHWAY	34	28	All SZGR 2.0 genes in this pathway
PID TNF PATHWAY	46	33	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
REACTOME IL1 SIGNALING	39	30	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP	372	227	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS	58	45	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
TAGHAVI NEOPLASTIC TRANSFORMATION	12	10	All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS	290	172	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON	335	181	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP	240	152	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
SUBTIL PROGESTIN TARGETS	36	25	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 UP	115	73	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38	337	236	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	1986	1992	1A	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
				hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-1/206	2269	2275	1A	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-122	2042	2048	1A	hsa-miR-122a	UGGAGUGUGACAAUGGUGUUUGU
miR-124.1	589	595	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	589	595	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	589	595	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-133	2115	2121	1A	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	2115	2121	1A	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-141/200a	391	397	1A	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
				hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
				hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
				hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-145	760	766	m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-15/16/195/424/497	73	79	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d	1452	1458	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-181	1461	1468	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-182	2078	2084	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-188	2514	2520	m8	hsa-miR-188	CAUCCCUUGCAUGGUGGAGGGU
miR-193	2486	2492	m8	hsa-miR-193a	AACUGGCCUACAAAGUCCCAG
miR-193	2486	2492	m8	hsa-miR-193b	AACUGGCCCUCAAAGUCCCGCUUU
miR-199	880	886	1A	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	880	886	1A	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-204/211	2513	2519	m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	2513	2519	m8	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-22	1820	1826	m8	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-23	1505	1511	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	1505	1511	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-28	1265	1271	m8	hsa-miR-28^brain	AAGGAGCUCACAGUCUAUUGAG
miR-323	1504	1511	1A,m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-33	701	707	m8	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	701	707	m8	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-338	2095	2101	m8	hsa-miR-338^brain	UCCAGCAUCAGUGAUUUUGUUGA
miR-363	2475	2481	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-410	1558	1564	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-496	1500	1506	m8	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-9	560	567	1A,m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-9	560	567	1A,m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-96	2077	2084	1A,m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: MAP3K3