Gene Page: DDX12P
Summary ?
| GeneID | 440081 |
| Symbol | DDX12P |
| Synonyms | CHLR2|DDX12 |
| Description | DEAD/H-box helicase 12, pseudogene |
| Reference | MIM:601151|HGNC:HGNC:2737| |
| Gene type | pseudo |
| Map location | 12p13.31 |
| Pascal p-value | 0.745 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 3 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg16514059 | 12 | 9600888 | DDX12P | 5.02E-10 | -0.008 | 8.59E-7 | DMG:Jaffe_2016 |
| cg07721440 | 12 | 9601161 | DDX12P | 3.8E-9 | -0.02 | 2.4E-6 | DMG:Jaffe_2016 |
| cg07909497 | 12 | 9600950 | DDX12P | 9.69E-9 | -0.016 | 4.28E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6487735 | 12 | 9431402 | DDX12P | ENSG00000214826.4 | 2.24E-8 | 0 | 169423 | gtex_brain_ba24 |
| rs5796344 | 12 | 9431770 | DDX12P | ENSG00000214826.4 | 7.09E-9 | 0 | 169055 | gtex_brain_ba24 |
| rs10771463 | 12 | 9432789 | DDX12P | ENSG00000214826.4 | 5.315E-7 | 0 | 168036 | gtex_brain_ba24 |
| rs10771464 | 12 | 9432850 | DDX12P | ENSG00000214826.4 | 1.488E-7 | 0 | 167975 | gtex_brain_ba24 |
| rs10743632 | 12 | 9432903 | DDX12P | ENSG00000214826.4 | 1.065E-7 | 0 | 167922 | gtex_brain_ba24 |
| rs10743633 | 12 | 9432952 | DDX12P | ENSG00000214826.4 | 1.065E-7 | 0 | 167873 | gtex_brain_ba24 |
| rs10743634 | 12 | 9432988 | DDX12P | ENSG00000214826.4 | 1.488E-7 | 0 | 167837 | gtex_brain_ba24 |
| rs2113900 | 12 | 9433426 | DDX12P | ENSG00000214826.4 | 2.872E-9 | 0 | 167399 | gtex_brain_ba24 |
| rs2113899 | 12 | 9433483 | DDX12P | ENSG00000214826.4 | 2.291E-9 | 0 | 167342 | gtex_brain_ba24 |
| rs1549430 | 12 | 9433605 | DDX12P | ENSG00000214826.4 | 1.627E-9 | 0 | 167220 | gtex_brain_ba24 |
| rs4514480 | 12 | 9433983 | DDX12P | ENSG00000214826.4 | 1.6E-9 | 0 | 166842 | gtex_brain_ba24 |
| rs10743636 | 12 | 9434060 | DDX12P | ENSG00000214826.4 | 2.815E-9 | 0 | 166765 | gtex_brain_ba24 |
| rs7300172 | 12 | 9434423 | DDX12P | ENSG00000214826.4 | 1.597E-9 | 0 | 166402 | gtex_brain_ba24 |
| rs7300369 | 12 | 9434538 | DDX12P | ENSG00000214826.4 | 2.24E-8 | 0 | 166287 | gtex_brain_ba24 |
| rs7135251 | 12 | 9434815 | DDX12P | ENSG00000214826.4 | 1.48E-9 | 0 | 166010 | gtex_brain_ba24 |
| rs1549429 | 12 | 9434842 | DDX12P | ENSG00000214826.4 | 1.429E-9 | 0 | 165983 | gtex_brain_ba24 |
| rs1549428 | 12 | 9434852 | DDX12P | ENSG00000214826.4 | 1.429E-9 | 0 | 165973 | gtex_brain_ba24 |
| rs1549427 | 12 | 9434940 | DDX12P | ENSG00000214826.4 | 1.053E-9 | 0 | 165885 | gtex_brain_ba24 |
| rs1549426 | 12 | 9435244 | DDX12P | ENSG00000214826.4 | 1.053E-9 | 0 | 165581 | gtex_brain_ba24 |
| rs6487747 | 12 | 9435574 | DDX12P | ENSG00000214826.4 | 1.053E-9 | 0 | 165251 | gtex_brain_ba24 |
| rs7960104 | 12 | 9435639 | DDX12P | ENSG00000214826.4 | 1.838E-9 | 0 | 165186 | gtex_brain_ba24 |
| rs6487748 | 12 | 9435768 | DDX12P | ENSG00000214826.4 | 1.073E-9 | 0 | 165057 | gtex_brain_ba24 |
| rs61916194 | 12 | 9436083 | DDX12P | ENSG00000214826.4 | 1.603E-8 | 0 | 164742 | gtex_brain_ba24 |
| rs7960183 | 12 | 9463357 | DDX12P | ENSG00000214826.4 | 1.644E-6 | 0 | 137468 | gtex_brain_ba24 |
| rs12366847 | 12 | 9463968 | DDX12P | ENSG00000214826.4 | 1.378E-6 | 0 | 136857 | gtex_brain_ba24 |
| rs3825322 | 12 | 9465134 | DDX12P | ENSG00000214826.4 | 1.864E-6 | 0 | 135691 | gtex_brain_ba24 |
| rs10771524 | 12 | 9472329 | DDX12P | ENSG00000214826.4 | 1.031E-6 | 0 | 128496 | gtex_brain_ba24 |
| rs71656520 | 12 | 9483965 | DDX12P | ENSG00000214826.4 | 1.684E-6 | 0 | 116860 | gtex_brain_ba24 |
| rs199636850 | 12 | 9485105 | DDX12P | ENSG00000214826.4 | 5.599E-7 | 0 | 115720 | gtex_brain_ba24 |
| rs7958717 | 12 | 9485106 | DDX12P | ENSG00000214826.4 | 1.698E-7 | 0 | 115719 | gtex_brain_ba24 |
| rs7974095 | 12 | 9485107 | DDX12P | ENSG00000214826.4 | 1.702E-7 | 0 | 115718 | gtex_brain_ba24 |
| rs7959473 | 12 | 9485725 | DDX12P | ENSG00000214826.4 | 1.067E-6 | 0 | 115100 | gtex_brain_ba24 |
| rs11049781 | 12 | 9399888 | DDX12P | ENSG00000214826.4 | 1.165E-6 | 0 | 200937 | gtex_brain_putamen_basal |
| rs12369816 | 12 | 9407282 | DDX12P | ENSG00000214826.4 | 1.165E-6 | 0 | 193543 | gtex_brain_putamen_basal |
| rs200038078 | 12 | 9411698 | DDX12P | ENSG00000214826.4 | 4.537E-7 | 0 | 189127 | gtex_brain_putamen_basal |
| rs11049845 | 12 | 9413442 | DDX12P | ENSG00000214826.4 | 1.21E-6 | 0 | 187383 | gtex_brain_putamen_basal |
| rs11049846 | 12 | 9413607 | DDX12P | ENSG00000214826.4 | 1.21E-6 | 0 | 187218 | gtex_brain_putamen_basal |
| rs10843253 | 12 | 9415915 | DDX12P | ENSG00000214826.4 | 9.734E-7 | 0 | 184910 | gtex_brain_putamen_basal |
| rs6487734 | 12 | 9427520 | DDX12P | ENSG00000214826.4 | 8.62E-7 | 0 | 173305 | gtex_brain_putamen_basal |
| rs6487735 | 12 | 9431402 | DDX12P | ENSG00000214826.4 | 2.251E-8 | 0 | 169423 | gtex_brain_putamen_basal |
| rs5796344 | 12 | 9431770 | DDX12P | ENSG00000214826.4 | 2.16E-9 | 0 | 169055 | gtex_brain_putamen_basal |
| rs10771463 | 12 | 9432789 | DDX12P | ENSG00000214826.4 | 5.612E-7 | 0 | 168036 | gtex_brain_putamen_basal |
| rs10771464 | 12 | 9432850 | DDX12P | ENSG00000214826.4 | 5.586E-7 | 0 | 167975 | gtex_brain_putamen_basal |
| rs10743632 | 12 | 9432903 | DDX12P | ENSG00000214826.4 | 1.681E-6 | 0 | 167922 | gtex_brain_putamen_basal |
| rs10743633 | 12 | 9432952 | DDX12P | ENSG00000214826.4 | 1.672E-6 | 0 | 167873 | gtex_brain_putamen_basal |
| rs10743634 | 12 | 9432988 | DDX12P | ENSG00000214826.4 | 2.396E-7 | 0 | 167837 | gtex_brain_putamen_basal |
| rs2113900 | 12 | 9433426 | DDX12P | ENSG00000214826.4 | 1.117E-8 | 0 | 167399 | gtex_brain_putamen_basal |
| rs2113899 | 12 | 9433483 | DDX12P | ENSG00000214826.4 | 5.628E-8 | 0 | 167342 | gtex_brain_putamen_basal |
| rs1549430 | 12 | 9433605 | DDX12P | ENSG00000214826.4 | 4.858E-8 | 0 | 167220 | gtex_brain_putamen_basal |
| rs4514480 | 12 | 9433983 | DDX12P | ENSG00000214826.4 | 4.837E-8 | 0 | 166842 | gtex_brain_putamen_basal |
| rs10743636 | 12 | 9434060 | DDX12P | ENSG00000214826.4 | 4.569E-9 | 0 | 166765 | gtex_brain_putamen_basal |
| rs7300172 | 12 | 9434423 | DDX12P | ENSG00000214826.4 | 4.83E-8 | 0 | 166402 | gtex_brain_putamen_basal |
| rs7300369 | 12 | 9434538 | DDX12P | ENSG00000214826.4 | 2.251E-8 | 0 | 166287 | gtex_brain_putamen_basal |
| rs7135251 | 12 | 9434815 | DDX12P | ENSG00000214826.4 | 4.375E-8 | 0 | 166010 | gtex_brain_putamen_basal |
| rs1549429 | 12 | 9434842 | DDX12P | ENSG00000214826.4 | 4.287E-8 | 0 | 165983 | gtex_brain_putamen_basal |
| rs1549428 | 12 | 9434852 | DDX12P | ENSG00000214826.4 | 4.287E-8 | 0 | 165973 | gtex_brain_putamen_basal |
| rs1549427 | 12 | 9434940 | DDX12P | ENSG00000214826.4 | 3.67E-8 | 0 | 165885 | gtex_brain_putamen_basal |
| rs1549426 | 12 | 9435244 | DDX12P | ENSG00000214826.4 | 3.67E-8 | 0 | 165581 | gtex_brain_putamen_basal |
| rs6487747 | 12 | 9435574 | DDX12P | ENSG00000214826.4 | 3.67E-8 | 0 | 165251 | gtex_brain_putamen_basal |
| rs7960104 | 12 | 9435639 | DDX12P | ENSG00000214826.4 | 7.956E-9 | 0 | 165186 | gtex_brain_putamen_basal |
| rs6487748 | 12 | 9435768 | DDX12P | ENSG00000214826.4 | 3.686E-8 | 0 | 165057 | gtex_brain_putamen_basal |
| rs61916194 | 12 | 9436083 | DDX12P | ENSG00000214826.4 | 1.859E-7 | 0 | 164742 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME DIABETES PATHWAYS | 133 | 91 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | 46 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME UNFOLDED PROTEIN RESPONSE | 80 | 51 | All SZGR 2.0 genes in this pathway |
| PATIL LIVER CANCER | 747 | 453 | All SZGR 2.0 genes in this pathway |
| WHITFIELD CELL CYCLE G1 S | 147 | 76 | All SZGR 2.0 genes in this pathway |