Gene Page: ATP1A1

Summary
GeneID  476
Symbol  ATP1A1
Synonyms  MGC3285|MGC51750
Description  ATPase, Na+/K+ transporting, alpha 1 polypeptide
See related  HGNC:799|MIM:182310|Ensembl:ENSG00000163399|HPRD:01662|
Locus tag  -
Gene type  protein-coding
Map location  1p21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PPL0.660.59
AC110760.20.590.60
ESRRG0.570.59
ECM10.570.48
FBLN70.560.56
GALR10.560.45
VSTM2A0.540.65
RET0.540.62
PKP10.540.40
KCNS20.540.58
Top 10 negatively co-expressed genes
IMPA2-0.24-0.36
AC098691.2-0.22-0.29
SIGIRR-0.22-0.33
RPL37-0.21-0.28
TAX1BP3-0.21-0.21
UXT-0.21-0.19
ANP32C-0.21-0.25
EMX2-0.21-0.32
EIF4EBP1-0.21-0.18
MPST-0.20-0.31
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:00038694-nitrophenylphosphatase activityIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI11027149 |15671290 
GO:0005524ATP bindingIEA-
GO:0005391sodium:potassium-exchanging ATPase activityIEA-
GO:0005391sodium:potassium-exchanging ATPase activityTAS1975705 
GO:0016787hydrolase activityIEA-
GO:0016820hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancesIEA-
GO:0015662ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanismIEA-
GO:0015077monovalent inorganic cation transmembrane transporter activityIEA-
GO:0030955potassium ion bindingIEA-
GO:0031402sodium ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002026regulation of the force of heart contractionIEA-
GO:0008217regulation of blood pressureIEA-
GO:0008152metabolic processIEA-
GO:0006814sodium ion transportIEA-
GO:0006812cation transportIEA-
GO:0006813potassium ion transportIEA-
GO:0006810transportIEA-
GO:0042493response to drugIEA-
GO:0030317sperm motilityISS-
GO:0030641regulation of cellular pHISS-
GO:0031947negative regulation of glucocorticoid biosynthetic processIEA-
GO:0045822negative regulation of heart contractionIEA-
GO:0045823positive regulation of heart contractionIEA-
GO:0045989positive regulation of striated muscle contractionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeIEA-
GO:0005624membrane fractionTAS1975705 
GO:0016020membraneIEA-
GO:0016021integral to membraneISS-
GO:0005890sodium:potassium-exchanging ATPase complexTAS1975705 
GO:0016323basolateral plasma membraneIEA-
GO:0042383sarcolemmaIEA-
GO:0042470melanosomeIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADD1ADDA | MGC3339 | MGC44427adducin 1 (alpha)-HPRD10516168 
CFL1CFLcofilin 1 (non-muscle)-HPRD11139403 
EZH2ENX-1 | EZH1 | KMT6 | MGC9169enhancer of zeste homolog 2 (Drosophila)Two-hybridBioGRID16169070 
FXYD1MGC44983 | PLMFXYD domain containing ion transport regulator 1-HPRD,BioGRID14597563 
FXYD7FLJ25096FXYD domain containing ion transport regulator 7-HPRD12093728 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1Biochemical ActivityBioGRID15069082 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3-HPRD,BioGRID15069082 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alphaBiochemical ActivityBioGRID15069082 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1A-HPRD14743216 
TNFRSF1BCD120b | TBPII | TNF-R-II | TNF-R75 | TNFBR | TNFR1B | TNFR2 | TNFR80 | p75 | p75TNFRtumor necrosis factor receptor superfamily, member 1B-HPRD14743216 
TPT1FLJ27337 | HRF | TCTP | p02tumor protein, translationally-controlled 1-HPRD15383549 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domain-HPRD14743216 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CARDIAC_MUSCLE_CONTRACTION 8051All SZGR genes in this pathway
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 4229All SZGR genes in this pathway
KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION 2316All SZGR genes in this pathway
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES 3421All SZGR genes in this pathway
REACTOME_ION_CHANNEL_TRANSPORT 5542All SZGR genes in this pathway
WATANABE_RECTAL_CANCER_RADIOTHERAPY_RESPONSIVE_UP 10867All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_BASAL_VS_MESENCHYMAL_UP 12145All SZGR genes in this pathway
DITTMER_PTHLH_TARGETS_UP 11268All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
CHEBOTAEV_GR_TARGETS_UP 7762All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_UP 271175All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP 169127All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
ALCALA_APOPTOSIS 8860All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_UP 11679All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
MORI_SMALL_PRE_BII_LYMPHOCYTE_DN 7652All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
SHEPARD_BMYB_TARGETS 7441All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN 185111All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_UP 205126All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 6647All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
ZHANG_TARGETS_OF_EWSR1_FLI1_FUSION 8868All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP 7752All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP 182119All SZGR genes in this pathway
XU_CREBBP_TARGETS_DN 4431All SZGR genes in this pathway
DELASERNA_MYOD_TARGETS_UP 8951All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_DN 9671All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_DN 5443All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_UP 170107All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP 178108All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN 193112All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_7 7646All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_DN 157106All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
BILANGES_SERUM_SENSITIVE_VIA_TSC2 3925All SZGR genes in this pathway
HOLLEMAN_DAUNORUBICIN_B_ALL_UP 109All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway


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