Gene Page: PDE1A

Summary ?
GeneID5136
SymbolPDE1A
SynonymsCAM-PDE-1A|HCAM-1|HCAM1|HSPDE1A
Descriptionphosphodiesterase 1A
ReferenceMIM:171890|HGNC:HGNC:8774|Ensembl:ENSG00000115252|HPRD:01387|Vega:OTTHUMG00000132596
Gene typeprotein-coding
Map location2q32.1
Pascal p-value0.025
Sherlock p-value0.414
Fetal beta0.102
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Hippocampus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs940335chr799159332PDE1A51360.17trans
rs109310212183368517PDE1AENSG00000115252.147.612E-7019402gtex_brain_putamen_basal
rs23683012183369652PDE1AENSG00000115252.146.274E-8018267gtex_brain_putamen_basal
rs97897642183373914PDE1AENSG00000115252.143.683E-6014005gtex_brain_putamen_basal
rs64339762183376081PDE1AENSG00000115252.144.07E-7011838gtex_brain_putamen_basal
rs75951112183376369PDE1AENSG00000115252.144.07E-7011550gtex_brain_putamen_basal
rs101758452183378125PDE1AENSG00000115252.143.501E-609794gtex_brain_putamen_basal
rs20821352183378257PDE1AENSG00000115252.144.047E-709662gtex_brain_putamen_basal
rs46668502183378710PDE1AENSG00000115252.144.044E-709209gtex_brain_putamen_basal
rs19915962183379073PDE1AENSG00000115252.143.21E-608846gtex_brain_putamen_basal
rs28872072183380721PDE1AENSG00000115252.145.189E-707198gtex_brain_putamen_basal
rs9342612183382345PDE1AENSG00000115252.143.897E-705574gtex_brain_putamen_basal
rs101743832183382731PDE1AENSG00000115252.143.706E-605188gtex_brain_putamen_basal
rs14301492183383268PDE1AENSG00000115252.143.86E-704651gtex_brain_putamen_basal
rs7202452183390144PDE1AENSG00000115252.143.732E-70-2225gtex_brain_putamen_basal
rs18353402183393811PDE1AENSG00000115252.143.781E-70-5892gtex_brain_putamen_basal
rs45803532183395232PDE1AENSG00000115252.141.46E-80-7313gtex_brain_putamen_basal
rs14301512183395511PDE1AENSG00000115252.143.902E-90-7592gtex_brain_putamen_basal
rs680987242183395631PDE1AENSG00000115252.143.902E-90-7712gtex_brain_putamen_basal
rs130271812183395815PDE1AENSG00000115252.143.9E-90-7896gtex_brain_putamen_basal
rs130268842183395835PDE1AENSG00000115252.143.9E-90-7916gtex_brain_putamen_basal
rs130268962183395871PDE1AENSG00000115252.143.9E-90-7952gtex_brain_putamen_basal
rs3978161952183396838PDE1AENSG00000115252.146.306E-90-8919gtex_brain_putamen_basal
rs126933092183397510PDE1AENSG00000115252.143.808E-90-9591gtex_brain_putamen_basal
rs126933102183397531PDE1AENSG00000115252.142.054E-80-9612gtex_brain_putamen_basal
rs126933112183397542PDE1AENSG00000115252.141.152E-80-9623gtex_brain_putamen_basal
rs116860032183397980PDE1AENSG00000115252.143.266E-90-10061gtex_brain_putamen_basal
rs14301522183398404PDE1AENSG00000115252.143.898E-90-10485gtex_brain_putamen_basal
rs354180112183398774PDE1AENSG00000115252.143.898E-90-10855gtex_brain_putamen_basal
rs121624222183398896PDE1AENSG00000115252.143.898E-90-10977gtex_brain_putamen_basal
rs114499462183399798PDE1AENSG00000115252.146.769E-70-11879gtex_brain_putamen_basal
rs353851352183400076PDE1AENSG00000115252.141.35E-80-12157gtex_brain_putamen_basal
rs116893242183400185PDE1AENSG00000115252.141.458E-80-12266gtex_brain_putamen_basal
rs124737832183400661PDE1AENSG00000115252.143.898E-90-12742gtex_brain_putamen_basal
rs101827882183400730PDE1AENSG00000115252.141.53E-130-12811gtex_brain_putamen_basal
rs15831132183401353PDE1AENSG00000115252.143.898E-90-13434gtex_brain_putamen_basal
rs14301532183401673PDE1AENSG00000115252.141.53E-130-13754gtex_brain_putamen_basal
rs14301542183401789PDE1AENSG00000115252.141.53E-130-13870gtex_brain_putamen_basal
rs75707602183402841PDE1AENSG00000115252.143.898E-90-14922gtex_brain_putamen_basal
rs14301552183403506PDE1AENSG00000115252.143.546E-70-15587gtex_brain_putamen_basal
rs109310232183403962PDE1AENSG00000115252.144.51E-100-16043gtex_brain_putamen_basal
rs19650892183404968PDE1AENSG00000115252.147.045E-110-17049gtex_brain_putamen_basal
rs75985872183407212PDE1AENSG00000115252.141.458E-80-19293gtex_brain_putamen_basal
rs23682812183408260PDE1AENSG00000115252.143.083E-70-20341gtex_brain_putamen_basal
rs9342622183409319PDE1AENSG00000115252.147.08E-80-21400gtex_brain_putamen_basal
rs9342632183409320PDE1AENSG00000115252.147.113E-80-21401gtex_brain_putamen_basal
rs67479542183415490PDE1AENSG00000115252.144.514E-120-27571gtex_brain_putamen_basal
rs67113132183416697PDE1AENSG00000115252.141.53E-130-28778gtex_brain_putamen_basal
rs46665882183417707PDE1AENSG00000115252.144.417E-130-29788gtex_brain_putamen_basal
rs14301562183423637PDE1AENSG00000115252.141.458E-80-35718gtex_brain_putamen_basal
rs46665892183424775PDE1AENSG00000115252.142.514E-70-36856gtex_brain_putamen_basal
rs1113263792183425701PDE1AENSG00000115252.141.144E-110-37782gtex_brain_putamen_basal
rs1398370682183428054PDE1AENSG00000115252.141.282E-80-40135gtex_brain_putamen_basal
rs75583482183428186PDE1AENSG00000115252.142.633E-60-40267gtex_brain_putamen_basal
rs109310242183441026PDE1AENSG00000115252.141.503E-60-53107gtex_brain_putamen_basal
rs124792862183441218PDE1AENSG00000115252.147.34E-70-53299gtex_brain_putamen_basal
rs76048732183441726PDE1AENSG00000115252.146.309E-110-53807gtex_brain_putamen_basal
rs67580802183442443PDE1AENSG00000115252.147.34E-70-54524gtex_brain_putamen_basal
rs75701442183443136PDE1AENSG00000115252.147.34E-70-55217gtex_brain_putamen_basal
rs15278782183446535PDE1AENSG00000115252.141.394E-90-58616gtex_brain_putamen_basal
rs19187002183449725PDE1AENSG00000115252.148.161E-110-61806gtex_brain_putamen_basal
rs44901432183450403PDE1AENSG00000115252.144.857E-100-62484gtex_brain_putamen_basal
rs23683302183453542PDE1AENSG00000115252.142.561E-60-65623gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
UGT80.960.94
PLP10.950.96
HSPA20.940.94
GLDN0.940.91
TF0.940.95
CNDP10.940.89
SLC31A20.940.78
ABCA80.930.89
KLK60.930.94
FOLH10.930.88
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NR2C2AP-0.53-0.78
NKIRAS2-0.53-0.68
TRNAU1AP-0.52-0.73
TBC1D10A-0.52-0.58
TUBB2B-0.52-0.80
ALKBH2-0.52-0.76
PLEKHO1-0.52-0.77
KIAA1949-0.51-0.74
CCDC28B-0.51-0.83
AC009133.1-0.51-0.69

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PURINE METABOLISM 15996All SZGR 2.0 genes in this pathway
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG TASTE TRANSDUCTION 5228All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME DAG AND IP3 SIGNALING 3225All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2 10178All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER 10980All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137105All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE 12788All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 7856All SZGR 2.0 genes in this pathway
REACTOME CA DEPENDENT EVENTS 3023All SZGR 2.0 genes in this pathway
REACTOME PLC BETA MEDIATED EVENTS 4332All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 12293All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 9576All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 12182All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 10074All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE 5440All SZGR 2.0 genes in this pathway
REACTOME CGMP EFFECTS 1913All SZGR 2.0 genes in this pathway
REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 2519All SZGR 2.0 genes in this pathway
REACTOME PLATELET HOMEOSTASIS 7849All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR 11280All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316190All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378231All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392251All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL SHORT TERM 3215All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314188All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR DN 191123All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP 295149All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510309All SZGR 2.0 genes in this pathway
WU ALZHEIMER DISEASE DN 1912All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway
CROONQUIST IL6 DEPRIVATION UP 2010All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445257All SZGR 2.0 genes in this pathway
NIELSEN GIST 9866All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448282All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244157All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279155All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227149All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297194All SZGR 2.0 genes in this pathway