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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: PDGFRB

Summary

GeneID

5159

Symbol

PDGFRB

Synonyms

CD140B|JTK12|PDGF-R-beta|PDGFR|PDGFR1

Description

platelet-derived growth factor receptor, beta polypeptide

Locus tag

Gene type

protein-coding

Map location

5q31-q32

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.0032

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.00459

GSMA_IIE

genome scan meta-analysis (European-ancestry samples)

Psr: 0.01718

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

PRDX3

0.79

0.78

POP4

0.78

0.75

TMEM111

0.78

0.76

GLO1

0.78

MOCS2

0.77

0.79

PEX19

0.76

0.75

SNX17

0.76

0.77

OCIAD1

0.76

0.74

CISD1

0.75

TMX2

0.75

0.73

Top 10 negatively co-expressed genes

AC010300.1

-0.44

-0.45

AF347015.18

-0.43

-0.23

HSP90AB4P

-0.43

-0.44

C10orf108

-0.41

-0.37

AC005921.3

-0.40

-0.48

AC100783.1

-0.40

-0.33

FAM159B

-0.37

-0.33

AL031587.2

-0.37

-0.30

AC135724.1

-0.37

-0.40

ZNF814

-0.35

-0.39

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0005021

vascular endothelial growth factor receptor activity

IEA

GO:0005019

platelet-derived growth factor beta-receptor activity

IDA

2536956

GO:0004872

receptor activity

IEA

GO:0005161

platelet-derived growth factor receptor binding

IPI

2542288

GO:0005524

ATP binding

IEA

GO:0004992

platelet activating factor receptor activity

TAS

2536956

GO:0016740

transferase activity

IEA

GO:0048407

platelet-derived growth factor binding

IPI

2536956

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007165

signal transduction

TAS

2536956 |10821867

GO:0008284

positive regulation of cell proliferation

IDA

17470632

GO:0048008

platelet-derived growth factor receptor signaling pathway

IDA

2536956

GO:0030335

positive regulation of cell migration

IDA

17470632

GO:0050730

regulation of peptidyl-tyrosine phosphorylation

IEA

GO:0046777

protein amino acid autophosphorylation

IDA

2536956

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0016020

membrane

IEA

GO:0016021

integral to membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BAG1	RAP46	BCL2-associated athanogene	-	HPRD	8947043
CAV1	CAV \| MSTP085 \| VIP21	caveolin 1, caveolae protein, 22kDa	Affinity Capture-Western Co-fractionation Reconstituted Complex	BioGRID	10066366
CAV3	LGMD1C \| LQT9 \| MGC126100 \| MGC126101 \| MGC126129 \| VIP-21 \| VIP21	caveolin 3	Reconstituted Complex	BioGRID	10066366
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	c-Cbl interacts with and ubiquitinates PDGF-R-beta. This interaction was modeled on a demonstrated interaction between human c-Cbl and PDGF-R-beta from an unspecified species.	BIND	10514377
COPA	FLJ26320 \| HEP-COP	coatomer protein complex, subunit alpha	-	HPRD,BioGRID	9207175
COPB1	COPB \| DKFZp761K102 \| FLJ10341	coatomer protein complex, subunit beta 1	-	HPRD	9207175
CRK	CRKII	v-crk sarcoma virus CT10 oncogene homolog (avian)	PDGFR interacts with Crk. This interaction was modelled on a demonstrated interaction between rat PDGFR and Crk from an unknown species.	BIND	2173144
CRK	CRKII	v-crk sarcoma virus CT10 oncogene homolog (avian)	-	HPRD,BioGRID	10733900
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	9506992
EIF2AK2	EIF2AK1 \| MGC126524 \| PKR \| PRKR	eukaryotic translation initiation factor 2-alpha kinase 2	Affinity Capture-Western	BioGRID	11350938
EPHB1	ELK \| EPHT2 \| FLJ37986 \| Hek6 \| NET	EPH receptor B1	Elk phosphorylates PDGFR. This interaction was modelled on a demonstrated interaction between Elk from an unknown species and human PDGFR.	BIND	7689724
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD	1696179
GRB10	GRB-IR \| Grb-10 \| IRBP \| KIAA0207 \| MEG1 \| RSS	growth factor receptor-bound protein 10	-	HPRD	9006901
GRB14	-	growth factor receptor-bound protein 14	-	HPRD,BioGRID	8647858
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	7935391
ITGB3	CD61 \| GP3A \| GPIIIa	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	Affinity Capture-Western	BioGRID	10964931
KRTAP4-12	KAP4.12 \| KRTAP4.12	keratin associated protein 4-12	Two-hybrid	BioGRID	16189514
NCK1	MGC12668 \| NCK \| NCKalpha	NCK adaptor protein 1	Autophosphorylated PDGFR interacts with Nck. This interaction was modelled on a demonstrated interaction between human PDGFR and Nck from an unspecified species.	BIND	8890167
			-	HPRD	9362449
			Affinity Capture-Western	BioGRID	1333047 \|10026169
NCK2	GRB4 \| NCKbeta	NCK adaptor protein 2	-	HPRD,BioGRID	11027258
PDAP1	HASPP28 \| PAP \| PAP1	PDGFA associated protein 1	-	HPRD	11331882
PDGFB	FLJ12858 \| PDGF2 \| SIS \| SSV \| c-sis	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	-	HPRD	11903042
PDGFD	IEGF \| MGC26867 \| MSTP036 \| SCDGF-B	platelet derived growth factor D	-	HPRD	14514732
PDGFRA	CD140A \| MGC74795 \| PDGFR2 \| Rhe-PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	Affinity Capture-Western Reconstituted Complex	BioGRID	2542288 \|7523122
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	Affinity Capture-Western Far Western	BioGRID	7523122 \|11046132
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	PDGFRB homodimerizes and cross-phosphorylates.	BIND	15889147
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	in vivo	BioGRID	10697503
			Beta-PDGFR interacts with p85. This interaction was modeled on a demonstrated interaction between human beta-PDGFR and rat or bovine p85.	BIND	1372092 \|7689724 \|7876130
			Phosphorylated beta-PDGFR interacts with p85-alpha. This interaction was modeled on a demonstrated interaction between human beta-PDGFR and bovine p85-alpha.	BIND	8388538
PIK3R2	P85B \| p85 \| p85-BETA	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	PDGFR interacts with p85-alpha. This interaction was modeled based on a demonstrated interaction between human PDGFR and p85-alpha from an unknown species.	BIND	11172806
PIK3R3	DKFZp686P05226 \| FLJ41892 \| p55 \| p55-GAMMA	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	PDGFR interacts with p55-gamma. This interaction was modeled based on a demonstrated interaction between human PDGFR and p55-gamma from an unknown species.	BIND	11172806
PLAUR	CD87 \| UPAR \| URKR	plasminogen activator, urokinase receptor	An unspecified isoform of PLAUR (uPAR) interacts with PDGFRB.	BIND	15889147
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	-	HPRD,BioGRID	8443409
			Autophosphorylated PDGFR interacts with PLC-gamma. This interaction was modelled on a demonstrated interaction between human PDGFR and PLC-gamma from an unspecified species.	BIND	8890167
			Phosphorylated beta-PDGFR interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between human beta-PDGFR and bovine PLC-gamma.	BIND	8388538
			Beta-PDGFR interacts with PLC-gamma 1. This interaction was modeled on a demonstrated interaction between human beta-PDGFR and PLC-gamma from bovine and unspecified sources.	BIND	2173144 \|7592796 \|7689724 \|7876130
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	-	HPRD	10806474
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	Reconstituted Complex Two-hybrid	BioGRID	7691811 \|11266449
			PDGFR interacts with Syp.	BIND	7688466
			Autophosphorylated PDGFR interacts with Syp. This interaction was modelled on a demonstrated interaction between human PDGFR and Syp from an unspecified species.	BIND	8890167
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD,BioGRID	2475255
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	Activated PDGFR interacts with GAP. This interaction was modeled on a demonstrated interaction between human PDGFR and canine GAP.	BIND	2157284
			N-terminal SH2 domain of GAP interacts with PDGFR. This interaction was modeled on a demonstrated interaction between GAP from human and PDGFR from an unspecified species.	BIND	1385407 \|2173144 \|7689724 \|8344248
			-	HPRD,BioGRID	10697503 \|11896619
			Autophosphorylated PDGFR interacts with GAP. This interaction was modelled on a demonstrated interaction between human PDGFR and GAP from an unspecified species.	BIND	8890167
S1PR1	CHEDG1 \| D1S3362 \| ECGF1 \| EDG-1 \| EDG1 \| FLJ58121 \| S1P1	sphingosine-1-phosphate receptor 1	-	HPRD,BioGRID	12480944
SH3KBP1	CIN85 \| GIG10 \| MIG18	SH3-domain kinase binding protein 1	-	HPRD,BioGRID	12177062
SHB	RP11-3J10.8 \| bA3J10.2	Src homology 2 domain containing adaptor protein B	Shb interacts with the PDGF beta-receptor.	BIND	7537362
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	PDGFR interacts with p52Shc	BIND	8195171
			PDGFR interacts with p66Shc.	BIND	8195171
			-	HPRD,BioGRID	8195171
			Autophosphorylated PDGFR interacts with SHC. This interaction was modelled on a demonstrated interaction between human PDGFR and SHC from an unspecified species.	BIND	8890167
SLC9A3R1	EBP50 \| NHERF \| NHERF1 \| NPHLOP2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	-	HPRD,BioGRID	11046132
SNX1	HsT17379 \| MGC8664 \| SNX1A \| Vps5	sorting nexin 1	-	HPRD,BioGRID	9819414
SNX2	MGC5204 \| TRG-9	sorting nexin 2	Affinity Capture-Western	BioGRID	9819414
SNX4	-	sorting nexin 4	Affinity Capture-Western	BioGRID	9819414
SOCS1	CIS1 \| CISH1 \| JAB \| SOCS-1 \| SSI-1 \| SSI1 \| TIP3	suppressor of cytokine signaling 1	Socs1 interacts with PDGF-R. This interaction was modeled on a demonstrated interaction between mouse Socs1 and human PDGF-R.	BIND	10022833
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	PDGFR interacts with Src. This interaction was modelled on a demonstrated interaction between rat PDGFR and Src from an unknown species.	BIND	2173144
VAV1	VAV	vav 1 guanine nucleotide exchange factor	Affinity Capture-Western	BioGRID	10938113
VAV2	-	vav 2 guanine nucleotide exchange factor	Affinity Capture-Western	BioGRID	10938113
VAV3	FLJ40431	vav 3 guanine nucleotide exchange factor	Affinity Capture-Western	BioGRID	10938113

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_MAPK_SIGNALING_PATHWAY	267	205	All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY	178	134	All SZGR genes in this pathway
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	267	161	All SZGR genes in this pathway
KEGG_FOCAL_ADHESION	201	138	All SZGR genes in this pathway
KEGG_GAP_JUNCTION	90	68	All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	216	144	All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER	328	259	All SZGR genes in this pathway
KEGG_GLIOMA	65	56	All SZGR genes in this pathway
KEGG_PROSTATE_CANCER	89	75	All SZGR genes in this pathway
KEGG_MELANOMA	71	57	All SZGR genes in this pathway
PID_PTP1B_PATHWAY	52	40	All SZGR genes in this pathway
PID_INTEGRIN3_PATHWAY	43	25	All SZGR genes in this pathway
PID_S1P_S1P3_PATHWAY	29	24	All SZGR genes in this pathway
PID_NECTIN_PATHWAY	30	20	All SZGR genes in this pathway
PID_TCPTP_PATHWAY	43	33	All SZGR genes in this pathway
PID_SHP2_PATHWAY	58	46	All SZGR genes in this pathway
PID_S1P_S1P1_PATHWAY	21	18	All SZGR genes in this pathway
PID_UPA_UPAR_PATHWAY	42	30	All SZGR genes in this pathway
PID_PDGFRB_PATHWAY	129	103	All SZGR genes in this pathway
PID_MYC_REPRESS_PATHWAY	63	52	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF	122	93	All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION	95	76	All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP	351	230	All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP	128	95	All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP	117	84	All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN	378	231	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP	552	347	All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP	211	136	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
CAIRO_PML_TARGETS_BOUND_BY_MYC_DN	14	12	All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN	394	258	All SZGR genes in this pathway
HAEGERSTRAND_RESPONSE_TO_IMATINIB	9	5	All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B	392	251	All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_27	15	8	All SZGR genes in this pathway
PATIL_LIVER_CANCER	747	453	All SZGR genes in this pathway
TERAMOTO_OPN_TARGETS_CLUSTER_6	27	17	All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP	358	245	All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_VIA_SMAD4_DN	66	38	All SZGR genes in this pathway
SASAI_RESISTANCE_TO_NEOPLASTIC_TRANSFROMATION	50	31	All SZGR genes in this pathway
THEODOROU_MAMMARY_TUMORIGENESIS	31	24	All SZGR genes in this pathway
WEI_MIR34A_TARGETS	148	97	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN	428	306	All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP	71	51	All SZGR genes in this pathway
ABRAHAM_ALPC_VS_MULTIPLE_MYELOMA_UP	26	22	All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN	408	274	All SZGR genes in this pathway
JAZAERI_BREAST_CANCER_BRCA1_VS_BRCA2_DN	43	31	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_DN	148	102	All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA_UP	52	33	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
GERHOLD_ADIPOGENESIS_DN	64	44	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_DN	178	121	All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_0HR	63	48	All SZGR genes in this pathway
JI_CARCINOGENESIS_BY_KRAS_AND_STK11_DN	17	12	All SZGR genes in this pathway
CLAUS_PGR_POSITIVE_MENINGIOMA_DN	12	10	All SZGR genes in this pathway
MISHRA_CARCINOMA_ASSOCIATED_FIBROBLAST_UP	24	14	All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP	973	570	All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN	228	114	All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN	342	220	All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP	323	240	All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN	138	92	All SZGR genes in this pathway
MOOTHA_PGC	420	269	All SZGR genes in this pathway
RUIZ_TNC_TARGETS_UP	153	107	All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN	435	289	All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK	1210	725	All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN	457	302	All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN	668	419	All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_UP	47	38	All SZGR genes in this pathway
MIKKELSEN_MEF_LCP_WITH_H3K4ME3	128	68	All SZGR genes in this pathway
MIKKELSEN_IPS_LCP_WITH_H3K4ME3	174	100	All SZGR genes in this pathway
NAKAYAMA_FGF2_TARGETS	29	17	All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN	253	192	All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP	682	433	All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES	462	273	All SZGR genes in this pathway
ANASTASSIOU_CANCER_MESENCHYMAL_TRANSITION_SIGNATURE	64	40	All SZGR genes in this pathway
DURAND_STROMA_S_UP	297	194	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-29	1907	1913	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-30-5p	1784	1790	1A	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-378	1123	1129	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-9	1763	1770	1A,m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.