Gene Page: PGC
Summary ?
| GeneID | 5225 |
| Symbol | PGC |
| Synonyms | PEPC|PGII |
| Description | progastricsin (pepsinogen C) |
| Reference | MIM:169740|HGNC:HGNC:8890|Ensembl:ENSG00000096088|HPRD:01357|Vega:OTTHUMG00000014683 |
| Gene type | protein-coding |
| Map location | 6p21.1 |
| Pascal p-value | 0.159 |
| Fetal beta | -0.194 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.04433 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| YME1L1 | 0.92 | 0.92 |
| SMU1 | 0.91 | 0.90 |
| VPS45 | 0.91 | 0.91 |
| C17orf80 | 0.91 | 0.92 |
| NUP133 | 0.91 | 0.92 |
| TSR1 | 0.90 | 0.92 |
| OSBPL9 | 0.90 | 0.91 |
| PSMD11 | 0.90 | 0.91 |
| NAP1L4 | 0.90 | 0.92 |
| SAR1A | 0.89 | 0.91 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.79 | -0.84 |
| MT-CO2 | -0.79 | -0.84 |
| AF347015.27 | -0.77 | -0.83 |
| AF347015.21 | -0.76 | -0.83 |
| AF347015.8 | -0.76 | -0.83 |
| AF347015.33 | -0.75 | -0.80 |
| MT-CYB | -0.75 | -0.81 |
| FXYD1 | -0.74 | -0.81 |
| IFI27 | -0.74 | -0.80 |
| AF347015.2 | -0.72 | -0.82 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004190 | aspartic-type endopeptidase activity | IEA | - | |
| GO:0004190 | aspartic-type endopeptidase activity | TAS | 3335549 | |
| GO:0008233 | peptidase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006508 | proteolysis | IEA | - | |
| GO:0006508 | proteolysis | TAS | 3335549 | |
| GO:0007586 | digestion | TAS | 3335549 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005576 | extracellular region | IEA | - | |
| GO:0005615 | extracellular space | TAS | 3335549 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| VECCHI GASTRIC CANCER EARLY DN | 367 | 220 | All SZGR 2.0 genes in this pathway |
| LIU CDX2 TARGETS UP | 36 | 22 | All SZGR 2.0 genes in this pathway |
| TAKAYAMA BOUND BY AR | 10 | 6 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| GRADE COLON AND RECTAL CANCER DN | 101 | 65 | All SZGR 2.0 genes in this pathway |
| MARTENS BOUND BY PML RARA FUSION | 456 | 287 | All SZGR 2.0 genes in this pathway |
| KOHOUTEK CCNT1 TARGETS | 50 | 26 | All SZGR 2.0 genes in this pathway |