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Gene Page: PLCG1

Summary

GeneID

5335

Symbol

PLCG1

Synonyms

PLC-II|PLC1|PLC148|PLCgamma1

Description

phospholipase C, gamma 1

Locus tag

Gene type

protein-coding

Map location

20q12-q13.1

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.4869

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

AVP

0.99

-0.04

OXT

0.99

-0.01

HCRT

0.99

0.29

TMEM190

0.97

0.21

TMEM146

0.94

0.34

FAM81B

0.93

0.26

FMO3

0.93

-0.14

WDR38

0.93

0.30

CD36

0.92

0.28

STOML3

0.92

0.34

Top 10 negatively co-expressed genes

AC008073.2

-0.10

-0.04

MGLL

-0.09

-0.31

RTN4RL2

-0.09

-0.15

FBXO32

-0.09

-0.08

NDRG1

-0.09

-0.10

CD163L1

-0.09

-0.20

AC016910.1

-0.08

-0.12

SLC26A4

-0.08

-0.13

TMEM110

-0.08

-0.28

HYAL1

-0.08

-0.26

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005057

receptor signaling protein activity

NAS

7681365

GO:0005509

calcium ion binding

IEA

GO:0005515

protein binding

IEA

GO:0005515

protein binding

IPI

10873601 |14722116

GO:0004435

phosphoinositide phospholipase C activity

IEA

GO:0004435

phosphoinositide phospholipase C activity

NAS

GO:0016787

hydrolase activity

IEA

GO:0008081

phosphoric diester hydrolase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0016042

lipid catabolic process

IEA

GO:0007242

intracellular signaling cascade

IEA

GO:0006629

lipid metabolic process

IEA

GO:0044419

interspecies interaction between organisms

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005829

cytosol

EXP

10350061 |11048639

GO:0005575

cellular_component

GO:0005737

cytoplasm

IDA

15702972

GO:0005886

plasma membrane

EXP

11048639

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	c-Abl interacts with PLC-gamma1. This interaction was modeled on a demonstrated interaction between human c-Abl and bovine PLCgamma1.	BIND	1383690
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	Reconstituted Complex	BioGRID	10708759
AGAP2	CENTG1 \| FLJ16430 \| GGAP2 \| KIAA0167 \| PIKE	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	-	HPRD	11823862
ALK	CD246 \| Ki-1 \| TFG/ALK	anaplastic lymphoma receptor tyrosine kinase	Affinity Capture-Western	BioGRID	11888936
ALK	CD246 \| Ki-1 \| TFG/ALK	anaplastic lymphoma receptor tyrosine kinase	-	HPRD	9174053
BAG3	BAG-3 \| BIS \| CAIR-1 \| MGC104307	BCL2-associated athanogene 3	-	HPRD,BioGRID	10980614
BCR	ALL \| BCR-ABL1 \| BCR1 \| CML \| D22S11 \| D22S662 \| FLJ16453 \| PHL	breakpoint cluster region	BCR interacts with PLCgamma1. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and bovine PLCgamma1.	BIND	1383690
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	-	HPRD,BioGRID	9712732 \|12061819
CD22	FLJ22814 \| MGC130020 \| SIGLEC-2 \| SIGLEC2	CD22 molecule	-	HPRD,BioGRID	8627166
CD28	MGC138290 \| Tp44	CD28 molecule	-	HPRD	8386518
CTSS	MGC3886	cathepsin S	-	HPRD	9164868
DAB1	-	disabled homolog 1 (Drosophila)	-	HPRD	15062102
DDR1	CAK \| CD167 \| DDR \| EDDR1 \| MCK10 \| NEP \| NTRK4 \| PTK3 \| PTK3A \| RTK6 \| TRKE	discoidin domain receptor tyrosine kinase 1	-	HPRD	10783152
DGKZ	DAGK5 \| DAGK6 \| DGK-ZETA \| hDGKzeta	diacylglycerol kinase, zeta 104kDa	-	HPRD,BioGRID	12890670
DOK1	MGC117395 \| MGC138860 \| P62DOK	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	Reconstituted Complex	BioGRID	11071635
EEF1A1	CCS-3 \| CCS3 \| EEF-1 \| EEF1A \| EF-Tu \| EF1A \| FLJ25721 \| GRAF-1EF \| HNGC:16303 \| LENG7 \| MGC102687 \| MGC131894 \| MGC16224 \| PTI1 \| eEF1A-1	eukaryotic translation elongation factor 1 alpha 1	-	HPRD,BioGRID	11886851
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	9207933
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA		EGFR interacts with PLC-gamma. This interaction was modelled on a demonstrated interaction between human EGFR and bovine PLC-gamma.	BIND	2173144 \|2176151
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	-	HPRD,BioGRID	1676673 \|1683701
FGFR1	BFGFR \| CD331 \| CEK \| FGFBR \| FLG \| FLJ99988 \| FLT2 \| HBGFR \| KAL2 \| N-SAM	fibroblast growth factor receptor 1	An unspecified isoform of FGFR1 interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human PLC-gamma.	BIND	15117958
FGFR1		fibroblast growth factor receptor 1	Two-hybrid	BioGRID	9660748
FGFR2	BEK \| BFR-1 \| CD332 \| CEK3 \| CFD1 \| ECT1 \| FLJ98662 \| JWS \| K-SAM \| KGFR \| TK14 \| TK25	fibroblast growth factor receptor 2	-	HPRD	7999363
FLT1	FLT \| VEGFR1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	Reconstituted Complex Two-hybrid	BioGRID	9398617
FLT1	FLT \| VEGFR1		Flt-1 interacts with the amino terminal SH2 domain of PLC-gamma.	BIND	9398617
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD	10586033
GAB1	-	GRB2-associated binding protein 1	-	HPRD,BioGRID	8596638
GAB2	KIAA0571	GRB2-associated binding protein 2	Reconstituted Complex	BioGRID	10391903
GHR	GHBP	growth hormone receptor	Reconstituted Complex	BioGRID	9632636
GIT1	-	G protein-coupled receptor kinase interacting ArfGAP 1	-	HPRD,BioGRID	14523024
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	-	HPRD,BioGRID	8290562
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	9281317
GSN	DKFZp313L0718	gelsolin (amyloidosis, Finnish type)	Reconstituted Complex	BioGRID	9164868
GTF2H1	BTF2 \| TFB1 \| TFIIH	general transcription factor IIH, polypeptide 1, 62kDa	-	HPRD	10467411
HCK	JTK9	hemopoietic cell kinase	-	HPRD	10586033
IRS2	-	insulin receptor substrate 2	-	HPRD,BioGRID	9535722
ITK	EMT \| LYK \| MGC126257 \| MGC126258 \| PSCTK2	IL2-inducible T-cell kinase	Affinity Capture-Western Biochemical Activity Reconstituted Complex	BioGRID	10586033 \|12163161
ITK	EMT \| LYK \| MGC126257 \| MGC126258 \| PSCTK2	IL2-inducible T-cell kinase	-	HPRD	10586033\|12163161
KDR	CD309 \| FLK1 \| VEGFR \| VEGFR2	kinase insert domain receptor (a type III receptor tyrosine kinase)	Reconstituted Complex	BioGRID	9398617
KHDRBS1	FLJ34027 \| Sam68 \| p62	KH domain containing, RNA binding, signal transduction associated 1	-	HPRD,BioGRID	9743338
KIT	C-Kit \| CD117 \| PBT \| SCFR	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	Kit interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between mouse proteins.	BIND	10022833
KIT	C-Kit \| CD117 \| PBT \| SCFR		-	HPRD,BioGRID	7536744
LAT	LAT1 \| pp36	linker for activation of T cells	-	HPRD,BioGRID	9729044 \|11368773
LAT	LAT1 \| pp36	linker for activation of T cells	LAT interacts with an unspecified isoform of PLC-gamma-1.	BIND	15696170
LAT2	HSPC046 \| LAB \| NTAL \| WBSCR15 \| WBSCR5 \| WSCR5	linker for activation of T cells family, member 2	-	HPRD,BioGRID	12514734
LCK	YT16 \| p56lck \| pp58lck	lymphocyte-specific protein tyrosine kinase	-	HPRD	1500851
LCP2	SLP-76 \| SLP76	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	-	HPRD,BioGRID	11390650
LIFR	CD118 \| FLJ98106 \| FLJ99923 \| LIF-R \| SJS2 \| STWS \| SWS	leukemia inhibitory factor receptor alpha	-	HPRD,BioGRID	7512571
LYN	FLJ26625 \| JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	-	HPRD	10586033
MST1R	CD136 \| CDw136 \| PTK8 \| RON	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	-	HPRD,BioGRID	8918464
NTRK1	DKFZp781I14186 \| MTC \| TRK \| TRK1 \| TRKA \| p140-TrkA	neurotrophic tyrosine kinase, receptor, type 1	-	HPRD,BioGRID	1715690
NTRK2	GP145-TrkB \| TRKB	neurotrophic tyrosine kinase, receptor, type 2	Reconstituted Complex Two-hybrid	BioGRID	10092678 \|12074588
NTRK3	TRKC \| gp145(trkC)	neurotrophic tyrosine kinase, receptor, type 3	Reconstituted Complex	BioGRID	10092678
NTRK3	TRKC \| gp145(trkC)	neurotrophic tyrosine kinase, receptor, type 3	-	HPRD	7657612
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	-	HPRD,BioGRID	12085993
PDGFA	PDGF-A \| PDGF1	platelet-derived growth factor alpha polypeptide	Affinity Capture-Western	BioGRID	8443409
PDGFRA	CD140A \| MGC74795 \| PDGFR2 \| Rhe-PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	-	HPRD,BioGRID	7535778
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	-	HPRD,BioGRID	8443409
			Autophosphorylated PDGFR interacts with PLC-gamma. This interaction was modelled on a demonstrated interaction between human PDGFR and PLC-gamma from an unspecified species.	BIND	8890167
			Phosphorylated beta-PDGFR interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between human beta-PDGFR and bovine PLC-gamma.	BIND	8388538
			Beta-PDGFR interacts with PLC-gamma 1. This interaction was modeled on a demonstrated interaction between human beta-PDGFR and PLC-gamma from bovine and unspecified sources.	BIND	2173144 \|7592796 \|7689724 \|7876130
PECAM1	CD31 \| PECAM-1	platelet/endothelial cell adhesion molecule	-	HPRD,BioGRID	10350061
PICALM	CALM \| CLTH \| LAP	phosphatidylinositol binding clathrin assembly protein	-	HPRD,BioGRID	10926122
PITPNA	MGC99649 \| PITPN \| VIB1A	phosphatidylinositol transfer protein, alpha	-	HPRD,BioGRID	7761838
PKN2	MGC150606 \| MGC71074 \| PAK2 \| PRK2 \| PRKCL2 \| PRO2042 \| Pak-2	protein kinase N2	-	HPRD,BioGRID	8910519
PLCG2	-	phospholipase C, gamma 2 (phosphatidylinositol-specific)	-	HPRD	8885868
PLD2	-	phospholipase D2	-	HPRD,BioGRID	12646582
PLD2	-	phospholipase D2	PLC-gamma1 interacts with PLD2. This interaction was modeled on a demonstrated interaction between PLC-gamma1 from an unspecified species and human PLD2.	BIND	14744865
PRKD1	PKC-MU \| PKCM \| PKD \| PRKCM	protein kinase D1	-	HPRD,BioGRID	8885868
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	-	HPRD,BioGRID	8660853\|10430888
PTPRJ	CD148 \| DEP1 \| HPTPeta \| R-PTP-ETA \| SCC1	protein tyrosine phosphatase, receptor type, J	-	HPRD,BioGRID	11259588
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	Affinity Capture-Western	BioGRID	9743338
RET	CDHF12 \| HSCR1 \| MEN2A \| MEN2B \| MTC1 \| PTC \| RET-ELE1 \| RET51	ret proto-oncogene	RET9 phosphorylates PLC-gamma via its amino-terminal SH2 domain. This interaction was modelled on a demonstrated interaction between RET9 from human and PLC-gamma from cow.	BIND	9047383
RET		ret proto-oncogene	-	HPRD,BioGRID	8628282
RHOA	ARH12 \| ARHA \| RHO12 \| RHOH12	ras homolog gene family, member A	-	HPRD,BioGRID	12071848
RHOU	ARHU \| CDC42L1 \| DJ646B12.2 \| FLJ10616 \| WRCH1 \| fJ646B12.2 \| hG28K	ras homolog gene family, member U	Wrch-1 interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between human Wrch-1 and PLC-gamma from an unspecified species.	BIND	15556869
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	-	HPRD,BioGRID	12454018
SELE	CD62E \| ELAM \| ELAM1 \| ESEL \| LECAM2	selectin E	-	HPRD,BioGRID	12960351
SH2B3	CELIAC13 \| LNK	SH2B adaptor protein 3	Affinity Capture-Western	BioGRID	8649391
SH3BP2	3BP2 \| CRBM \| CRPM \| FLJ42079 \| RES4-23	SH3-domain binding protein 2	-	HPRD,BioGRID	11390470
SHB	RP11-3J10.8 \| bA3J10.2	Src homology 2 domain containing adaptor protein B	Affinity Capture-Western	BioGRID	10488157
SHB	RP11-3J10.8 \| bA3J10.2	Src homology 2 domain containing adaptor protein B	-	HPRD	12084069
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	Affinity Capture-Western	BioGRID	8662733
SNAP91	AP180 \| CALM \| DKFZp781O0519 \| KIAA0656	synaptosomal-associated protein, 91kDa homolog (mouse)	-	HPRD	11779129
SOCS7	NAP4	suppressor of cytokine signaling 7	-	HPRD	9344857
SOS1	GF1 \| GGF1 \| GINGF \| HGF \| NS4	son of sevenless homolog 1 (Drosophila)	-	HPRD,BioGRID	10913276
SOS2	FLJ25596	son of sevenless homolog 2 (Drosophila)	-	HPRD,BioGRID	10940929
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD,BioGRID	7510703
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	Affinity Capture-Western	BioGRID	7831290
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	-	HPRD	8885868
SYN1	SYN1a \| SYN1b \| SYNI	synapsin I	-	HPRD	10899172
SYNCRIP	GRY-RBP \| HNRPQ1 \| NSAP1 \| RP1-3J17.2 \| dJ3J17.2 \| hnRNP-Q \| pp68	synaptotagmin binding, cytoplasmic RNA interacting protein	Reconstituted Complex	BioGRID	9341187
TNK1	MGC46193	tyrosine kinase, non-receptor, 1	-	HPRD,BioGRID	10873601
TRPC3	TRP3	transient receptor potential cation channel, subfamily C, member 3	PLCG1 interacts with TRPC3. This interaction was modelled on a demonstrated interaction between rat PLCG1 and human TRPC3.	BIND	15744307
TRPC3	TRP3		-	HPRD	15744307 \|15766521
TRPM7	CHAK \| CHAK1 \| FLJ20117 \| FLJ25718 \| LTRPC7 \| TRP-PLIK	transient receptor potential cation channel, subfamily M, member 7	-	HPRD,BioGRID	11941371
TUB	rd5	tubby homolog (mouse)	-	HPRD,BioGRID	10455176
USO1	P115 \| TAP \| VDP	USO1 homolog, vesicle docking protein (yeast)	-	HPRD	12507498
VAV1	VAV	vav 1 guanine nucleotide exchange factor	-	HPRD,BioGRID	9891995
VAV3	FLJ40431	vav 3 guanine nucleotide exchange factor	-	HPRD	11094073
WAS	IMD2 \| THC \| WASP	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	Reconstituted Complex	BioGRID	8805332 \|8824280
WAS	IMD2 \| THC \| WASP	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	-	HPRD	8892607
ZAP70	FLJ17670 \| FLJ17679 \| SRK \| STD \| TZK \| ZAP-70	zeta-chain (TCR) associated protein kinase 70kDa	-	HPRD,BioGRID	7629168

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_INOSITOL_PHOSPHATE_METABOLISM	54	42	All SZGR genes in this pathway
KEGG_ERBB_SIGNALING_PATHWAY	87	71	All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY	178	134	All SZGR genes in this pathway
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	76	56	All SZGR genes in this pathway
KEGG_VEGF_SIGNALING_PATHWAY	76	53	All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	137	92	All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY	108	89	All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY	79	58	All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS	97	71	All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	118	78	All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	126	103	All SZGR genes in this pathway
KEGG_VIBRIO_CHOLERAE_INFECTION	56	32	All SZGR genes in this pathway
KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	68	44	All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER	328	259	All SZGR genes in this pathway
KEGG_GLIOMA	65	56	All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER	54	47	All SZGR genes in this pathway
BIOCARTA_BCR_PATHWAY	37	28	All SZGR genes in this pathway
BIOCARTA_BIOPEPTIDES_PATHWAY	45	35	All SZGR genes in this pathway
BIOCARTA_CXCR4_PATHWAY	24	22	All SZGR genes in this pathway
BIOCARTA_CALCINEURIN_PATHWAY	21	17	All SZGR genes in this pathway
BIOCARTA_EGF_PATHWAY	31	25	All SZGR genes in this pathway
BIOCARTA_EPO_PATHWAY	19	13	All SZGR genes in this pathway
BIOCARTA_FCER1_PATHWAY	41	30	All SZGR genes in this pathway
BIOCARTA_GH_PATHWAY	28	22	All SZGR genes in this pathway
BIOCARTA_PYK2_PATHWAY	31	24	All SZGR genes in this pathway
BIOCARTA_NGF_PATHWAY	18	13	All SZGR genes in this pathway
BIOCARTA_VIP_PATHWAY	29	26	All SZGR genes in this pathway
BIOCARTA_PDGF_PATHWAY	32	25	All SZGR genes in this pathway
BIOCARTA_CCR5_PATHWAY	20	16	All SZGR genes in this pathway
BIOCARTA_PTDINS_PATHWAY	23	16	All SZGR genes in this pathway
BIOCARTA_CARDIACEGF_PATHWAY	18	16	All SZGR genes in this pathway
BIOCARTA_ERK5_PATHWAY	18	15	All SZGR genes in this pathway
BIOCARTA_GPCR_PATHWAY	37	31	All SZGR genes in this pathway
BIOCARTA_TCR_PATHWAY	49	37	All SZGR genes in this pathway
BIOCARTA_TPO_PATHWAY	24	17	All SZGR genes in this pathway
BIOCARTA_TRKA_PATHWAY	12	10	All SZGR genes in this pathway
BIOCARTA_VEGF_PATHWAY	29	18	All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY	82	62	All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION	45	33	All SZGR genes in this pathway
PID_FCER1_PATHWAY	62	43	All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY	66	53	All SZGR genes in this pathway
PID_TCR_PATHWAY	66	51	All SZGR genes in this pathway
PID_MET_PATHWAY	80	60	All SZGR genes in this pathway
PID_S1P_S1P4_PATHWAY	14	11	All SZGR genes in this pathway
PID_CDC42_REG_PATHWAY	30	22	All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY	53	42	All SZGR genes in this pathway
PID_S1P_S1P1_PATHWAY	21	18	All SZGR genes in this pathway
PID_NETRIN_PATHWAY	32	27	All SZGR genes in this pathway
PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY	35	29	All SZGR genes in this pathway
PID_PI3KCI_PATHWAY	49	40	All SZGR genes in this pathway
PID_EPHA_FWDPATHWAY	34	29	All SZGR genes in this pathway
PID_ECADHERIN_KERATINOCYTE_PATHWAY	21	19	All SZGR genes in this pathway
PID_PDGFRB_PATHWAY	129	103	All SZGR genes in this pathway
PID_TRKR_PATHWAY	62	48	All SZGR genes in this pathway
PID_NEPHRIN_NEPH1_PATHWAY	31	24	All SZGR genes in this pathway
PID_PDGFRA_PATHWAY	22	18	All SZGR genes in this pathway
PID_AR_NONGENOMIC_PATHWAY	31	27	All SZGR genes in this pathway
PID_VEGFR1_PATHWAY	26	23	All SZGR genes in this pathway
PID_EPO_PATHWAY	34	29	All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY	69	57	All SZGR genes in this pathway
PID_NCADHERIN_PATHWAY	33	32	All SZGR genes in this pathway
PID_PI3K_PLC_TRK_PATHWAY	36	31	All SZGR genes in this pathway
PID_FGF_PATHWAY	55	37	All SZGR genes in this pathway
PID_FAK_PATHWAY	59	45	All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF	217	167	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_DAG_AND_IP3_SIGNALING	32	25	All SZGR genes in this pathway
REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES	66	45	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2	101	78	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR	18	13	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER	109	80	All SZGR genes in this pathway
REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	29	24	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR	126	90	All SZGR genes in this pathway
REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS	19	18	All SZGR genes in this pathway
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL	91	65	All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE	137	105	All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_ERKS	36	30	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE	127	88	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR1_MUTANTS	30	20	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS	19	12	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_MUTANTS	44	29	All SZGR genes in this pathway
REACTOME_PECAM1_INTERACTIONS	10	7	All SZGR genes in this pathway
REACTOME_TCR_SIGNALING	54	46	All SZGR genes in this pathway
REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES	27	25	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF	122	93	All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION	95	76	All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE	251	188	All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR	100	74	All SZGR genes in this pathway
REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE	54	40	All SZGR genes in this pathway
REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING	11	8	All SZGR genes in this pathway
REACTOME_NETRIN1_SIGNALING	41	30	All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING	159	116	All SZGR genes in this pathway
REACTOME_HEMOSTASIS	466	331	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM	539	350	All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM	270	204	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR	112	80	All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP	567	375	All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN	162	116	All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP	185	126	All SZGR genes in this pathway
PATIL_LIVER_CANCER	747	453	All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK	1652	1023	All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK	1442	892	All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_DN	187	122	All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN	337	230	All SZGR genes in this pathway
CROMER_METASTASIS_UP	79	46	All SZGR genes in this pathway
HALMOS_CEBPA_TARGETS_UP	52	34	All SZGR genes in this pathway
RADMACHER_AML_PROGNOSIS	78	52	All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3	491	310	All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN	353	226	All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP	973	570	All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_DN	108	64	All SZGR genes in this pathway
GU_PDEF_TARGETS_UP	71	49	All SZGR genes in this pathway
HOFMANN_MYELODYSPLASTIC_SYNDROM_HIGH_RISK_UP	10	7	All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION	368	247	All SZGR genes in this pathway
STAMBOLSKY_TARGETS_OF_MUTATED_TP53_UP	49	35	All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN	180	116	All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D	658	397	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	218	224	m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-129-5p	209	215	m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	209	215	m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-135	150	156	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	150	156	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-182	1182	1188	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-218	235	241	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-218	235	241	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-30-5p	418	424	1A	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-320	434	440	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-331	612	618	1A	hsa-miR-331^brain	GCCCCUGGGCCUAUCCUAGAA
miR-34/449	1180	1186	1A	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-370	25	31	m8	hsa-miR-370^brain	GCCUGCUGGGGUGGAACCUGG
miR-450	209	215	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-96	1182	1188	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.