SZGR2

Summary ?

GeneID	5335
Symbol	PLCG1
Synonyms	NCKAP3\|PLC-II\|PLC1\|PLC148\|PLCgamma1
Description	phospholipase C gamma 1
Reference	MIM:172420\|HGNC:HGNC:9065\|Ensembl:ENSG00000124181\|HPRD:01398\|Vega:OTTHUMG00000033082
Gene type	protein-coding
Map location	20q12-q13.1
Pascal p-value	2.48E-4
Sherlock p-value	0.877
eGene	Myers' cis & trans
Support	INTRACELLULAR SIGNAL TRANSDUCTION G2Cdb.humanNRC G2Cdb.humanPSP Ascano FMRP targets Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.4869

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs16829545	chr2	151977407	PLCG1	5335	0.12	trans
rs3845734	chr2	171125572	PLCG1	5335	0.14	trans
rs16955618	chr15	29937543	PLCG1	5335	2.274E-4	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AVP	0.99	-0.04
OXT	0.99	-0.01
HCRT	0.99	0.29
TMEM190	0.97	0.21
TMEM146	0.94	0.34
FAM81B	0.93	0.26
FMO3	0.93	-0.14
WDR38	0.93	0.30
CD36	0.92	0.28
STOML3	0.92	0.34

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AC008073.2	-0.10	-0.04
MGLL	-0.09	-0.31
RTN4RL2	-0.09	-0.15
FBXO32	-0.09	-0.08
NDRG1	-0.09	-0.10
CD163L1	-0.09	-0.20
AC016910.1	-0.08	-0.12
SLC26A4	-0.08	-0.13
TMEM110	-0.08	-0.28
HYAL1	-0.08	-0.26

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005057	receptor signaling protein activity	NAS		7681365
GO:0005509	calcium ion binding	IEA		-
GO:0005515	protein binding	IEA		-
GO:0005515	protein binding	IPI		10873601 \|14722116
GO:0004435	phosphoinositide phospholipase C activity	IEA		-
GO:0004435	phosphoinositide phospholipase C activity	NAS		-
GO:0016787	hydrolase activity	IEA		-
GO:0008081	phosphoric diester hydrolase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0016042	lipid catabolic process	IEA		-
GO:0007242	intracellular signaling cascade	IEA		-
GO:0006629	lipid metabolic process	IEA		-
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		10350061 \|11048639
GO:0005575	cellular_component	ND		-
GO:0005737	cytoplasm	IDA		15702972
GO:0005886	plasma membrane	EXP		11048639

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	c-Abl interacts with PLC-gamma1. This interaction was modeled on a demonstrated interaction between human c-Abl and bovine PLCgamma1.	BIND	1383690
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	Reconstituted Complex	BioGRID	10708759
AGAP2	CENTG1 \| FLJ16430 \| GGAP2 \| KIAA0167 \| PIKE	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	-	HPRD	11823862
ALK	CD246 \| Ki-1 \| TFG/ALK	anaplastic lymphoma receptor tyrosine kinase	Affinity Capture-Western	BioGRID	11888936
ALK	CD246 \| Ki-1 \| TFG/ALK	anaplastic lymphoma receptor tyrosine kinase	-	HPRD	9174053
BAG3	BAG-3 \| BIS \| CAIR-1 \| MGC104307	BCL2-associated athanogene 3	-	HPRD,BioGRID	10980614
BCR	ALL \| BCR-ABL1 \| BCR1 \| CML \| D22S11 \| D22S662 \| FLJ16453 \| PHL	breakpoint cluster region	BCR interacts with PLCgamma1. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and bovine PLCgamma1.	BIND	1383690
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	-	HPRD,BioGRID	9712732 \|12061819
CD22	FLJ22814 \| MGC130020 \| SIGLEC-2 \| SIGLEC2	CD22 molecule	-	HPRD,BioGRID	8627166
CD28	MGC138290 \| Tp44	CD28 molecule	-	HPRD	8386518
CTSS	MGC3886	cathepsin S	-	HPRD	9164868
DAB1	-	disabled homolog 1 (Drosophila)	-	HPRD	15062102
DDR1	CAK \| CD167 \| DDR \| EDDR1 \| MCK10 \| NEP \| NTRK4 \| PTK3 \| PTK3A \| RTK6 \| TRKE	discoidin domain receptor tyrosine kinase 1	-	HPRD	10783152
DGKZ	DAGK5 \| DAGK6 \| DGK-ZETA \| hDGKzeta	diacylglycerol kinase, zeta 104kDa	-	HPRD,BioGRID	12890670
DOK1	MGC117395 \| MGC138860 \| P62DOK	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	Reconstituted Complex	BioGRID	11071635
EEF1A1	CCS-3 \| CCS3 \| EEF-1 \| EEF1A \| EF-Tu \| EF1A \| FLJ25721 \| GRAF-1EF \| HNGC:16303 \| LENG7 \| MGC102687 \| MGC131894 \| MGC16224 \| PTI1 \| eEF1A-1	eukaryotic translation elongation factor 1 alpha 1	-	HPRD,BioGRID	11886851
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	9207933
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	EGFR interacts with PLC-gamma. This interaction was modelled on a demonstrated interaction between human EGFR and bovine PLC-gamma.	BIND	2173144 \|2176151
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	-	HPRD,BioGRID	1676673 \|1683701
FGFR1	BFGFR \| CD331 \| CEK \| FGFBR \| FLG \| FLJ99988 \| FLT2 \| HBGFR \| KAL2 \| N-SAM	fibroblast growth factor receptor 1	An unspecified isoform of FGFR1 interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human PLC-gamma.	BIND	15117958
FGFR1	BFGFR \| CD331 \| CEK \| FGFBR \| FLG \| FLJ99988 \| FLT2 \| HBGFR \| KAL2 \| N-SAM	fibroblast growth factor receptor 1	Two-hybrid	BioGRID	9660748
FGFR2	BEK \| BFR-1 \| CD332 \| CEK3 \| CFD1 \| ECT1 \| FLJ98662 \| JWS \| K-SAM \| KGFR \| TK14 \| TK25	fibroblast growth factor receptor 2	-	HPRD	7999363
FLT1	FLT \| VEGFR1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	Reconstituted Complex Two-hybrid	BioGRID	9398617
FLT1	FLT \| VEGFR1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	Flt-1 interacts with the amino terminal SH2 domain of PLC-gamma.	BIND	9398617
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD	10586033
GAB1	-	GRB2-associated binding protein 1	-	HPRD,BioGRID	8596638
GAB2	KIAA0571	GRB2-associated binding protein 2	Reconstituted Complex	BioGRID	10391903
GHR	GHBP	growth hormone receptor	Reconstituted Complex	BioGRID	9632636
GIT1	-	G protein-coupled receptor kinase interacting ArfGAP 1	-	HPRD,BioGRID	14523024
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	-	HPRD,BioGRID	8290562
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	9281317
GSN	DKFZp313L0718	gelsolin (amyloidosis, Finnish type)	Reconstituted Complex	BioGRID	9164868
GTF2H1	BTF2 \| TFB1 \| TFIIH	general transcription factor IIH, polypeptide 1, 62kDa	-	HPRD	10467411
HCK	JTK9	hemopoietic cell kinase	-	HPRD	10586033
IRS2	-	insulin receptor substrate 2	-	HPRD,BioGRID	9535722
ITK	EMT \| LYK \| MGC126257 \| MGC126258 \| PSCTK2	IL2-inducible T-cell kinase	Affinity Capture-Western Biochemical Activity Reconstituted Complex	BioGRID	10586033 \|12163161
ITK	EMT \| LYK \| MGC126257 \| MGC126258 \| PSCTK2	IL2-inducible T-cell kinase	-	HPRD	10586033\|12163161
KDR	CD309 \| FLK1 \| VEGFR \| VEGFR2	kinase insert domain receptor (a type III receptor tyrosine kinase)	Reconstituted Complex	BioGRID	9398617
KHDRBS1	FLJ34027 \| Sam68 \| p62	KH domain containing, RNA binding, signal transduction associated 1	-	HPRD,BioGRID	9743338
KIT	C-Kit \| CD117 \| PBT \| SCFR	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	Kit interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between mouse proteins.	BIND	10022833
KIT	C-Kit \| CD117 \| PBT \| SCFR	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	-	HPRD,BioGRID	7536744
LAT	LAT1 \| pp36	linker for activation of T cells	-	HPRD,BioGRID	9729044 \|11368773
LAT	LAT1 \| pp36	linker for activation of T cells	LAT interacts with an unspecified isoform of PLC-gamma-1.	BIND	15696170
LAT2	HSPC046 \| LAB \| NTAL \| WBSCR15 \| WBSCR5 \| WSCR5	linker for activation of T cells family, member 2	-	HPRD,BioGRID	12514734
LCK	YT16 \| p56lck \| pp58lck	lymphocyte-specific protein tyrosine kinase	-	HPRD	1500851
LCP2	SLP-76 \| SLP76	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	-	HPRD,BioGRID	11390650
LIFR	CD118 \| FLJ98106 \| FLJ99923 \| LIF-R \| SJS2 \| STWS \| SWS	leukemia inhibitory factor receptor alpha	-	HPRD,BioGRID	7512571
LYN	FLJ26625 \| JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	-	HPRD	10586033
MST1R	CD136 \| CDw136 \| PTK8 \| RON	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	-	HPRD,BioGRID	8918464
NTRK1	DKFZp781I14186 \| MTC \| TRK \| TRK1 \| TRKA \| p140-TrkA	neurotrophic tyrosine kinase, receptor, type 1	-	HPRD,BioGRID	1715690
NTRK2	GP145-TrkB \| TRKB	neurotrophic tyrosine kinase, receptor, type 2	Reconstituted Complex Two-hybrid	BioGRID	10092678 \|12074588
NTRK3	TRKC \| gp145(trkC)	neurotrophic tyrosine kinase, receptor, type 3	Reconstituted Complex	BioGRID	10092678
NTRK3	TRKC \| gp145(trkC)	neurotrophic tyrosine kinase, receptor, type 3	-	HPRD	7657612
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	-	HPRD,BioGRID	12085993
PDGFA	PDGF-A \| PDGF1	platelet-derived growth factor alpha polypeptide	Affinity Capture-Western	BioGRID	8443409
PDGFRA	CD140A \| MGC74795 \| PDGFR2 \| Rhe-PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	-	HPRD,BioGRID	7535778
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	-	HPRD,BioGRID	8443409
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	Autophosphorylated PDGFR interacts with PLC-gamma. This interaction was modelled on a demonstrated interaction between human PDGFR and PLC-gamma from an unspecified species.	BIND	8890167
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	Phosphorylated beta-PDGFR interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between human beta-PDGFR and bovine PLC-gamma.	BIND	8388538
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	Beta-PDGFR interacts with PLC-gamma 1. This interaction was modeled on a demonstrated interaction between human beta-PDGFR and PLC-gamma from bovine and unspecified sources.	BIND	2173144 \|7592796 \|7689724 \|7876130
PECAM1	CD31 \| PECAM-1	platelet/endothelial cell adhesion molecule	-	HPRD,BioGRID	10350061
PICALM	CALM \| CLTH \| LAP	phosphatidylinositol binding clathrin assembly protein	-	HPRD,BioGRID	10926122
PITPNA	MGC99649 \| PITPN \| VIB1A	phosphatidylinositol transfer protein, alpha	-	HPRD,BioGRID	7761838
PKN2	MGC150606 \| MGC71074 \| PAK2 \| PRK2 \| PRKCL2 \| PRO2042 \| Pak-2	protein kinase N2	-	HPRD,BioGRID	8910519
PLCG2	-	phospholipase C, gamma 2 (phosphatidylinositol-specific)	-	HPRD	8885868
PLD2	-	phospholipase D2	-	HPRD,BioGRID	12646582
PLD2	-	phospholipase D2	PLC-gamma1 interacts with PLD2. This interaction was modeled on a demonstrated interaction between PLC-gamma1 from an unspecified species and human PLD2.	BIND	14744865
PRKD1	PKC-MU \| PKCM \| PKD \| PRKCM	protein kinase D1	-	HPRD,BioGRID	8885868
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	-	HPRD,BioGRID	8660853\|10430888
PTPRJ	CD148 \| DEP1 \| HPTPeta \| R-PTP-ETA \| SCC1	protein tyrosine phosphatase, receptor type, J	-	HPRD,BioGRID	11259588
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	Affinity Capture-Western	BioGRID	9743338
RET	CDHF12 \| HSCR1 \| MEN2A \| MEN2B \| MTC1 \| PTC \| RET-ELE1 \| RET51	ret proto-oncogene	RET9 phosphorylates PLC-gamma via its amino-terminal SH2 domain. This interaction was modelled on a demonstrated interaction between RET9 from human and PLC-gamma from cow.	BIND	9047383
RET	CDHF12 \| HSCR1 \| MEN2A \| MEN2B \| MTC1 \| PTC \| RET-ELE1 \| RET51	ret proto-oncogene	-	HPRD,BioGRID	8628282
RHOA	ARH12 \| ARHA \| RHO12 \| RHOH12	ras homolog gene family, member A	-	HPRD,BioGRID	12071848
RHOU	ARHU \| CDC42L1 \| DJ646B12.2 \| FLJ10616 \| WRCH1 \| fJ646B12.2 \| hG28K	ras homolog gene family, member U	Wrch-1 interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between human Wrch-1 and PLC-gamma from an unspecified species.	BIND	15556869
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	-	HPRD,BioGRID	12454018
SELE	CD62E \| ELAM \| ELAM1 \| ESEL \| LECAM2	selectin E	-	HPRD,BioGRID	12960351
SH2B3	CELIAC13 \| LNK	SH2B adaptor protein 3	Affinity Capture-Western	BioGRID	8649391
SH3BP2	3BP2 \| CRBM \| CRPM \| FLJ42079 \| RES4-23	SH3-domain binding protein 2	-	HPRD,BioGRID	11390470
SHB	RP11-3J10.8 \| bA3J10.2	Src homology 2 domain containing adaptor protein B	Affinity Capture-Western	BioGRID	10488157
SHB	RP11-3J10.8 \| bA3J10.2	Src homology 2 domain containing adaptor protein B	-	HPRD	12084069
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	Affinity Capture-Western	BioGRID	8662733
SNAP91	AP180 \| CALM \| DKFZp781O0519 \| KIAA0656	synaptosomal-associated protein, 91kDa homolog (mouse)	-	HPRD	11779129
SOCS7	NAP4	suppressor of cytokine signaling 7	-	HPRD	9344857
SOS1	GF1 \| GGF1 \| GINGF \| HGF \| NS4	son of sevenless homolog 1 (Drosophila)	-	HPRD,BioGRID	10913276
SOS2	FLJ25596	son of sevenless homolog 2 (Drosophila)	-	HPRD,BioGRID	10940929
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD,BioGRID	7510703
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	Affinity Capture-Western	BioGRID	7831290
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	-	HPRD	8885868
SYN1	SYN1a \| SYN1b \| SYNI	synapsin I	-	HPRD	10899172
SYNCRIP	GRY-RBP \| HNRPQ1 \| NSAP1 \| RP1-3J17.2 \| dJ3J17.2 \| hnRNP-Q \| pp68	synaptotagmin binding, cytoplasmic RNA interacting protein	Reconstituted Complex	BioGRID	9341187
TNK1	MGC46193	tyrosine kinase, non-receptor, 1	-	HPRD,BioGRID	10873601
TRPC3	TRP3	transient receptor potential cation channel, subfamily C, member 3	PLCG1 interacts with TRPC3. This interaction was modelled on a demonstrated interaction between rat PLCG1 and human TRPC3.	BIND	15744307
TRPC3	TRP3	transient receptor potential cation channel, subfamily C, member 3	-	HPRD	15744307 \|15766521
TRPM7	CHAK \| CHAK1 \| FLJ20117 \| FLJ25718 \| LTRPC7 \| TRP-PLIK	transient receptor potential cation channel, subfamily M, member 7	-	HPRD,BioGRID	11941371
TUB	rd5	tubby homolog (mouse)	-	HPRD,BioGRID	10455176
USO1	P115 \| TAP \| VDP	USO1 homolog, vesicle docking protein (yeast)	-	HPRD	12507498
VAV1	VAV	vav 1 guanine nucleotide exchange factor	-	HPRD,BioGRID	9891995
VAV3	FLJ40431	vav 3 guanine nucleotide exchange factor	-	HPRD	11094073
WAS	IMD2 \| THC \| WASP	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	Reconstituted Complex	BioGRID	8805332 \|8824280
WAS	IMD2 \| THC \| WASP	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	-	HPRD	8892607
ZAP70	FLJ17670 \| FLJ17679 \| SRK \| STD \| TZK \| ZAP-70	zeta-chain (TCR) associated protein kinase 70kDa	-	HPRD,BioGRID	7629168

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG INOSITOL PHOSPHATE METABOLISM	54	42	All SZGR 2.0 genes in this pathway
KEGG ERBB SIGNALING PATHWAY	87	71	All SZGR 2.0 genes in this pathway
KEGG CALCIUM SIGNALING PATHWAY	178	134	All SZGR 2.0 genes in this pathway
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM	76	56	All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY	76	53	All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY	137	92	All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY	108	89	All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY	79	58	All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS	97	71	All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION	118	78	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG VIBRIO CHOLERAE INFECTION	56	32	All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION	68	44	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG GLIOMA	65	56	All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER	54	47	All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY	37	28	All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY	45	35	All SZGR 2.0 genes in this pathway
BIOCARTA CXCR4 PATHWAY	24	22	All SZGR 2.0 genes in this pathway
BIOCARTA CALCINEURIN PATHWAY	21	17	All SZGR 2.0 genes in this pathway
BIOCARTA EGF PATHWAY	31	25	All SZGR 2.0 genes in this pathway
BIOCARTA EPO PATHWAY	19	13	All SZGR 2.0 genes in this pathway
BIOCARTA FCER1 PATHWAY	41	30	All SZGR 2.0 genes in this pathway
BIOCARTA GH PATHWAY	28	22	All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY	31	24	All SZGR 2.0 genes in this pathway
BIOCARTA NGF PATHWAY	18	13	All SZGR 2.0 genes in this pathway
BIOCARTA VIP PATHWAY	29	26	All SZGR 2.0 genes in this pathway
BIOCARTA PDGF PATHWAY	32	25	All SZGR 2.0 genes in this pathway
BIOCARTA CCR5 PATHWAY	20	16	All SZGR 2.0 genes in this pathway
BIOCARTA PTDINS PATHWAY	23	16	All SZGR 2.0 genes in this pathway
BIOCARTA CARDIACEGF PATHWAY	18	16	All SZGR 2.0 genes in this pathway
BIOCARTA ERK5 PATHWAY	18	15	All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY	37	31	All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY	49	37	All SZGR 2.0 genes in this pathway
BIOCARTA TPO PATHWAY	24	17	All SZGR 2.0 genes in this pathway
BIOCARTA TRKA PATHWAY	12	10	All SZGR 2.0 genes in this pathway
BIOCARTA VEGF PATHWAY	29	18	All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY	82	62	All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION	45	33	All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY	62	43	All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY	66	53	All SZGR 2.0 genes in this pathway
PID TCR PATHWAY	66	51	All SZGR 2.0 genes in this pathway
PID MET PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID S1P S1P4 PATHWAY	14	11	All SZGR 2.0 genes in this pathway
PID CDC42 REG PATHWAY	30	22	All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY	53	42	All SZGR 2.0 genes in this pathway
PID S1P S1P1 PATHWAY	21	18	All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY	32	27	All SZGR 2.0 genes in this pathway
PID ERBB1 RECEPTOR PROXIMAL PATHWAY	35	29	All SZGR 2.0 genes in this pathway
PID PI3KCI PATHWAY	49	40	All SZGR 2.0 genes in this pathway
PID EPHA FWDPATHWAY	34	29	All SZGR 2.0 genes in this pathway
PID ECADHERIN KERATINOCYTE PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY	62	48	All SZGR 2.0 genes in this pathway
PID NEPHRIN NEPH1 PATHWAY	31	24	All SZGR 2.0 genes in this pathway
PID PDGFRA PATHWAY	22	18	All SZGR 2.0 genes in this pathway
PID AR NONGENOMIC PATHWAY	31	27	All SZGR 2.0 genes in this pathway
PID VEGFR1 PATHWAY	26	23	All SZGR 2.0 genes in this pathway
PID EPO PATHWAY	34	29	All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY	69	57	All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY	33	32	All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK PATHWAY	36	31	All SZGR 2.0 genes in this pathway
PID FGF PATHWAY	55	37	All SZGR 2.0 genes in this pathway
PID FAK PATHWAY	59	45	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME DAG AND IP3 SIGNALING	32	25	All SZGR 2.0 genes in this pathway
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	66	45	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	18	13	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	29	24	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	126	90	All SZGR 2.0 genes in this pathway
REACTOME PROLONGED ERK ACTIVATION EVENTS	19	18	All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	91	65	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS	36	30	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR1 MUTANTS	30	20	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	19	12	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR MUTANTS	44	29	All SZGR 2.0 genes in this pathway
REACTOME PECAM1 INTERACTIONS	10	7	All SZGR 2.0 genes in this pathway
REACTOME TCR SIGNALING	54	46	All SZGR 2.0 genes in this pathway
REACTOME GENERATION OF SECOND MESSENGER MOLECULES	27	25	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE	54	40	All SZGR 2.0 genes in this pathway
REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	11	8	All SZGR 2.0 genes in this pathway
REACTOME NETRIN1 SIGNALING	41	30	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING	159	116	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN	162	116	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP	185	126	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN	187	122	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
CROMER METASTASIS UP	79	46	All SZGR 2.0 genes in this pathway
HALMOS CEBPA TARGETS UP	52	34	All SZGR 2.0 genes in this pathway
RADMACHER AML PROGNOSIS	78	52	All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3	491	310	All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN	353	226	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS DN	108	64	All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP	71	49	All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM HIGH RISK UP	10	7	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION	368	247	All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 UP	49	35	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN	180	116	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	218	224	m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-129-5p	209	215	m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	209	215	m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-135	150	156	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	150	156	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-182	1182	1188	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-218	235	241	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-218	235	241	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-30-5p	418	424	1A	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-320	434	440	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-331	612	618	1A	hsa-miR-331^brain	GCCCCUGGGCCUAUCCUAGAA
miR-34/449	1180	1186	1A	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-370	25	31	m8	hsa-miR-370^brain	GCCUGCUGGGGUGGAACCUGG
miR-450	209	215	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-96	1182	1188	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PLCG1