Gene Page: PLG

Summary
GeneID  5340
Symbol  PLG
Synonyms  DKFZp779M0222
Description  plasminogen
See related  HGNC:9071|MIM:173350|Ensembl:ENSG00000122194|HPRD:01417|
Locus tag  RP1-81D8.1
Gene type  protein-coding
Map location  6q26
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0033 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
METTL11A0.900.89
C19orf620.880.88
AP2S10.880.87
TIMM500.880.85
MANBAL0.870.84
CDK50.870.84
TSFM0.870.82
FIBP0.860.85
ASNA10.860.83
FLOT10.850.84
Top 10 negatively co-expressed genes
AF347015.18-0.58-0.43
AF347015.26-0.56-0.41
AF347015.2-0.54-0.37
AF347015.8-0.49-0.34
AF347015.15-0.48-0.34
MT-CO2-0.47-0.30
MT-CYB-0.47-0.33
AC010300.1-0.47-0.47
AC016705.1-0.47-0.40
AL139819.3-0.47-0.39
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityTASglutamate (GO term level: 7)9242524 
GO:0005509calcium ion bindingIEA-
GO:0008233peptidase activityIEA-
GO:0034185apolipoprotein bindingIPI16480936 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0006917induction of apoptosisIEA-
GO:0006917induction of apoptosisTAS11257124 
GO:0008285negative regulation of cell proliferationTAS8910613 
GO:0007596blood coagulationIMP1986355 
GO:0006915apoptosisIEA-
GO:0042246tissue regenerationIEA-
GO:0016525negative regulation of angiogenesisTAS11257124 
GO:0043537negative regulation of blood vessel endothelial cell migrationTAS11257124 
GO:0046716muscle maintenanceIEA-
GO:0045445myoblast differentiationIEA-
GO:0048771tissue remodelingIEA-
GO:0051918negative regulation of fibrinolysisIDA14726399 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP2318848 |2962641 
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA6216475 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTG1ACT | ACTG | DFNA20 | DFNA26actin, gamma 1PLG interacts with ACTG1 (G-actin). This interaction was modelled on a demonstrated interaction between human PLG and bovine ACTG1.BIND15746964 
AMOTKIAA1071angiomotin-HPRD11257124 
ANXA2ANX2 | ANX2L4 | CAL1H | LIP2 | LPC2 | LPC2D | P36 | PAP-IVannexin A2-HPRD10077593 
ATP5BATPMB | ATPSB | MGC5231ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide-HPRD10077593 
C7-complement component 7-HPRD,BioGRID7814888 
CHGACGAchromogranin A (parathyroid secretory protein 1)-HPRD,BioGRID11342539 
CLEC3BDKFZp686H17246 | TN | TNAC-type lectin domain family 3, member B-HPRD10964919 
CPB2CPU | PCPB | TAFIcarboxypeptidase B2 (plasma)-HPRD,BioGRID1939207 
CXCL2CINC-2a | GRO2 | GROb | MGSA-b | MIP-2a | MIP2 | MIP2A | SCYB2chemokine (C-X-C motif) ligand 2-HPRD,BioGRID10928473 
ENO1ENO1L1 | MBP-1 | MPB1 | NNE | PPHenolase 1, (alpha)Reconstituted ComplexBioGRID11169399 
F10FX | FXAcoagulation factor X-HPRD,BioGRID11371191 
F3CD142 | TF | TFAcoagulation factor III (thromboplastin, tissue factor)-HPRD,BioGRID9490681 
HMGB1DKFZp686A04236 | HMG1 | HMG3 | SBP-1high-mobility group box 1-HPRD,BioGRID1909331 
HRGDKFZp779H1622 | HPRG | HRGPhistidine-rich glycoprotein-HPRD8478593 
IGFBP3BP-53 | IBP3insulin-like growth factor binding protein 3-HPRD,BioGRID9688635 
KNG1BDK | KNGkininogen 1-HPRD,BioGRID9428707 
LAMA1LAMAlaminin, alpha 1-HPRD,BioGRID8360181 
LAMA3BM600 | E170 | LAMNA | LOCS | lama3alaminin, alpha 3-HPRD10956663 
LAMA5KIAA1907laminin, alpha 5Reconstituted ComplexBioGRID10956663 
NGFBeta-NGF | HSAN5 | MGC161426 | MGC161428 | NGFBnerve growth factor (beta polypeptide)-HPRD11729324 
PAPPAASBABP2 | DIPLA1 | IGFBP-4ase | PAPA | PAPP-A | PAPPA1pregnancy-associated plasma protein A, pappalysin 1Biochemical ActivityBioGRID7586586 
PLAUATF | UPA | URK | UROKINASE | u-PAplasminogen activator, urokinase-HPRD2829380 |3920216 
PRNPASCR | CD230 | CJD | GSS | MGC26679 | PRIP | PrP | PrP27-30 | PrP33-35C | PrPc | prionprion proteinPrPSc interacts with PLG.BIND11438139 
S100A1042C | ANX2L | ANX2LG | CAL1L | CLP11 | Ca[1] | GP11 | MGC111133 | P11 | p10S100 calcium binding protein A10-HPRD,BioGRID11939791 
SERPINC1AT3 | ATIII | MGC22579serpin peptidase inhibitor, clade C (antithrombin), member 1-HPRD10974350 
SERPINE1PAI | PAI-1 | PAI1 | PLANH1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1Reconstituted ComplexBioGRID11113116 
SERPINF2A2AP | AAP | ALPHA-2-PI | API | PLIserpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2-HPRD,BioGRID158022 |2437112 
|3334852 
SPARCONsecreted protein, acidic, cysteine-rich (osteonectin)-HPRD,BioGRID2745554 |7982919 
TFPI2FLJ21164 | PP5 | REF1 | TFPI-2tissue factor pathway inhibitor 2-HPRD8555184 
THBS1THBS | TSP | TSP1thrombospondin 1-HPRD,BioGRID2522013 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 6949All SZGR genes in this pathway
BIOCARTA_AMI_PATHWAY 2013All SZGR genes in this pathway
BIOCARTA_FIBRINOLYSIS_PATHWAY 128All SZGR genes in this pathway
BIOCARTA_PLATELETAPP_PATHWAY 1410All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_P75_NTR_PATHWAY 6951All SZGR genes in this pathway
PID_AMB2_NEUTROPHILS_PATHWAY 4132All SZGR genes in this pathway
PID_SYNDECAN_4_PATHWAY 3225All SZGR genes in this pathway
PID_UPA_UPAR_PATHWAY 4230All SZGR genes in this pathway
REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX 2911All SZGR genes in this pathway
REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION 8742All SZGR genes in this pathway
REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 8956All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS 1612All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_UP 8858All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
RANKIN_ANGIOGENIC_TARGETS_OF_VHL_HIF2A_UP 55All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_UP 165100All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
HOEGERKORP_CD44_TARGETS_DIRECT_UP 2721All SZGR genes in this pathway
XU_GH1_EXOGENOUS_TARGETS_DN 12069All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
LEE_LIVER_CANCER 4929All SZGR genes in this pathway
OUILLETTE_CLL_13Q14_DELETION_DN 6038All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN 274165All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_UP 10264All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_UP 212128All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_DN 17997All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_UP 8550All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SURVIVAL_DN 11376All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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