Gene Page: PLG

Summary ?
GeneID5340
SymbolPLG
Synonyms-
Descriptionplasminogen
ReferenceMIM:173350|HGNC:HGNC:9071|Ensembl:ENSG00000122194|HPRD:01417|Vega:OTTHUMG00000015957
Gene typeprotein-coding
Map location6q26
Pascal p-value0.037
Fetal beta0.028

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0033 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
METTL11A0.900.89
C19orf620.880.88
AP2S10.880.87
TIMM500.880.85
MANBAL0.870.84
CDK50.870.84
TSFM0.870.82
FIBP0.860.85
ASNA10.860.83
FLOT10.850.84
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.18-0.58-0.43
AF347015.26-0.56-0.41
AF347015.2-0.54-0.37
AF347015.8-0.49-0.34
AF347015.15-0.48-0.34
MT-CO2-0.47-0.30
MT-CYB-0.47-0.33
AC010300.1-0.47-0.47
AC016705.1-0.47-0.40
AL139819.3-0.47-0.39

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityTASglutamate (GO term level: 7)9242524 
GO:0005509calcium ion bindingIEA-
GO:0008233peptidase activityIEA-
GO:0034185apolipoprotein bindingIPI16480936 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0006917induction of apoptosisIEA-
GO:0006917induction of apoptosisTAS11257124 
GO:0008285negative regulation of cell proliferationTAS8910613 
GO:0007596blood coagulationIMP1986355 
GO:0006915apoptosisIEA-
GO:0042246tissue regenerationIEA-
GO:0016525negative regulation of angiogenesisTAS11257124 
GO:0043537negative regulation of blood vessel endothelial cell migrationTAS11257124 
GO:0046716muscle maintenanceIEA-
GO:0045445myoblast differentiationIEA-
GO:0048771tissue remodelingIEA-
GO:0051918negative regulation of fibrinolysisIDA14726399 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP2318848 |2962641 
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA6216475 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTG1ACT | ACTG | DFNA20 | DFNA26actin, gamma 1PLG interacts with ACTG1 (G-actin). This interaction was modelled on a demonstrated interaction between human PLG and bovine ACTG1.BIND15746964 
AMOTKIAA1071angiomotin-HPRD11257124 
ANXA2ANX2 | ANX2L4 | CAL1H | LIP2 | LPC2 | LPC2D | P36 | PAP-IVannexin A2-HPRD10077593 
ATP5BATPMB | ATPSB | MGC5231ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide-HPRD10077593 
C7-complement component 7-HPRD,BioGRID7814888 
CHGACGAchromogranin A (parathyroid secretory protein 1)-HPRD,BioGRID11342539 
CLEC3BDKFZp686H17246 | TN | TNAC-type lectin domain family 3, member B-HPRD10964919 
CPB2CPU | PCPB | TAFIcarboxypeptidase B2 (plasma)-HPRD,BioGRID1939207 
CXCL2CINC-2a | GRO2 | GROb | MGSA-b | MIP-2a | MIP2 | MIP2A | SCYB2chemokine (C-X-C motif) ligand 2-HPRD,BioGRID10928473 
ENO1ENO1L1 | MBP-1 | MPB1 | NNE | PPHenolase 1, (alpha)Reconstituted ComplexBioGRID11169399 
F10FX | FXAcoagulation factor X-HPRD,BioGRID11371191 
F3CD142 | TF | TFAcoagulation factor III (thromboplastin, tissue factor)-HPRD,BioGRID9490681 
HMGB1DKFZp686A04236 | HMG1 | HMG3 | SBP-1high-mobility group box 1-HPRD,BioGRID1909331 
HRGDKFZp779H1622 | HPRG | HRGPhistidine-rich glycoprotein-HPRD8478593 
IGFBP3BP-53 | IBP3insulin-like growth factor binding protein 3-HPRD,BioGRID9688635 
KNG1BDK | KNGkininogen 1-HPRD,BioGRID9428707 
LAMA1LAMAlaminin, alpha 1-HPRD,BioGRID8360181 
LAMA3BM600 | E170 | LAMNA | LOCS | lama3alaminin, alpha 3-HPRD10956663 
LAMA5KIAA1907laminin, alpha 5Reconstituted ComplexBioGRID10956663 
NGFBeta-NGF | HSAN5 | MGC161426 | MGC161428 | NGFBnerve growth factor (beta polypeptide)-HPRD11729324 
PAPPAASBABP2 | DIPLA1 | IGFBP-4ase | PAPA | PAPP-A | PAPPA1pregnancy-associated plasma protein A, pappalysin 1Biochemical ActivityBioGRID7586586 
PLAUATF | UPA | URK | UROKINASE | u-PAplasminogen activator, urokinase-HPRD2829380 |3920216 
PRNPASCR | CD230 | CJD | GSS | MGC26679 | PRIP | PrP | PrP27-30 | PrP33-35C | PrPc | prionprion proteinPrPSc interacts with PLG.BIND11438139 
S100A1042C | ANX2L | ANX2LG | CAL1L | CLP11 | Ca[1] | GP11 | MGC111133 | P11 | p10S100 calcium binding protein A10-HPRD,BioGRID11939791 
SERPINC1AT3 | ATIII | MGC22579serpin peptidase inhibitor, clade C (antithrombin), member 1-HPRD10974350 
SERPINE1PAI | PAI-1 | PAI1 | PLANH1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1Reconstituted ComplexBioGRID11113116 
SERPINF2A2AP | AAP | ALPHA-2-PI | API | PLIserpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2-HPRD,BioGRID158022 |2437112 
|3334852 
SPARCONsecreted protein, acidic, cysteine-rich (osteonectin)-HPRD,BioGRID2745554 |7982919 
TFPI2FLJ21164 | PP5 | REF1 | TFPI-2tissue factor pathway inhibitor 2-HPRD8555184 
THBS1THBS | TSP | TSP1thrombospondin 1-HPRD,BioGRID2522013 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
KEGG COMPLEMENT AND COAGULATION CASCADES 6949All SZGR 2.0 genes in this pathway
BIOCARTA AMI PATHWAY 2013All SZGR 2.0 genes in this pathway
BIOCARTA FIBRINOLYSIS PATHWAY 128All SZGR 2.0 genes in this pathway
BIOCARTA PLATELETAPP PATHWAY 1410All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY 5041All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY 6951All SZGR 2.0 genes in this pathway
PID AMB2 NEUTROPHILS PATHWAY 4132All SZGR 2.0 genes in this pathway
PID SYNDECAN 4 PATHWAY 3225All SZGR 2.0 genes in this pathway
PID UPA UPAR PATHWAY 4230All SZGR 2.0 genes in this pathway
REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX 2911All SZGR 2.0 genes in this pathway
REACTOME EXTRACELLULAR MATRIX ORGANIZATION 8742All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 8956All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 13391All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 1612All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 12293All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP 8858All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514319All SZGR 2.0 genes in this pathway
RANKIN ANGIOGENIC TARGETS OF VHL HIF2A UP 55All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT UP 165100All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
HOEGERKORP CD44 TARGETS DIRECT UP 2721All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS DN 12069All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
LEE LIVER CANCER 4929All SZGR 2.0 genes in this pathway
OUILLETTE CLL 13Q14 DELETION DN 6038All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274165All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS UP 10264All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 13892All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE UP 212128All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN 17997All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED UP 8550All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL DN 11376All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222141All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157105All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238125All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway